The Role of Staphylococcus aureus Virulence Factors in Skin Infection and Their Potential as Vaccine Antigens KA Lacey, JA Geoghegan, RM McLoughlin Pathogens 5 (1), 22, 2016 | 184 | 2016 |
Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection AF Brown, AG Murphy, SJ Lalor, JM Leech, KM O’Keeffe, M Mac Aogáin, ... PLoS pathogens 11 (11), e1005226, 2015 | 174 | 2015 |
IL-10 plays opposing roles during Staphylococcus aureus systemic and localized infections JM Leech, KA Lacey, ME Mulcahy, E Medina, RM McLoughlin The Journal of Immunology 198 (6), 2352-2365, 2017 | 96 | 2017 |
Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target KA Lacey, ME Mulcahy, AM Towell, JA Geoghegan, RM McLoughlin PLoS pathogens 15 (4), e1007713, 2019 | 66 | 2019 |
Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin AN Spaan, AL Neehus, E Laplantine, F Staels, M Ogishi, Y Seeleuthner, ... Science 376 (6599), eabm6380, 2022 | 37 | 2022 |
The Staphylococcus aureus cell wall-anchored protein clumping factor A is an important T cell antigen KA Lacey, JM Leech, SJ Lalor, N McCormack, JA Geoghegan, ... Infection and immunity 85 (12), 10.1128/iai. 00549-17, 2017 | 31 | 2017 |
The cell envelope of Staphylococcus aureus selectively controls the sorting of virulence factors X Zheng, G Marsman, KA Lacey, JR Chapman, C Goosmann, ... Nature Communications 12 (1), 6193, 2021 | 30 | 2021 |
Targeting leukocidin-mediated immune evasion protects mice from Staphylococcus aureus bacteremia K Tam, KA Lacey, JC Devlin, M Coffre, A Sommerfield, R Chan, ... Journal of Experimental Medicine 217 (9), e20190541, 2020 | 29 | 2020 |
Identification of a domain critical for Staphylococcus aureus LukED receptor targeting and lysis of erythrocytes MT Vasquez, A Lubkin, T Reyes-Robles, CJ Day, KA Lacey, MP Jennings, ... Journal of Biological Chemistry 295 (50), 17241-17250, 2020 | 28 | 2020 |
Exploiting species specificity to understand the tropism of a human-specific toxin KM Boguslawski, AN McKeown, CJ Day, KA Lacey, K Tam, N Vozhilla, ... Science Advances 6 (11), eaax7515, 2020 | 26 | 2020 |
Rewilding of laboratory mice enhances granulopoiesis and immunity through intestinal fungal colonization YH Chen, F Yeung, KA Lacey, K Zaldana, JD Lin, GCW Bee, C McCauley, ... Science immunology 8 (84), eadd6910, 2023 | 21 | 2023 |
Multivalent human antibody-centyrin fusion protein to prevent and treat Staphylococcus aureus infections PT Buckley, R Chan, J Fernandez, J Luo, KA Lacey, AL DuMont, ... Cell Host & Microbe 31 (5), 751-765. e11, 2023 | 18 | 2023 |
Staphylococcus aureus induces a muted host response in human blood that blunts the recruitment of neutrophils EE Zwack, Z Chen, JC Devlin, Z Li, X Zheng, A Weinstock, KA Lacey, ... Proceedings of the National Academy of Sciences 119 (31), e2123017119, 2022 | 18 | 2022 |
A small membrane stabilizing protein critical to the pathogenicity of Staphylococcus aureus S Duggan, M Laabei, AA Alnahari, EC O’Brien, KA Lacey, L Bacon, ... Infection and immunity 88 (9), 10.1128/iai. 00162-20, 2020 | 16 | 2020 |
Secreted mammalian DNases protect against systemic bacterial infection by digesting biofilms KA Lacey, L Serpas, S Makita, Y Wang, A Rashidfarrokhi, C Soni, ... Journal of Experimental Medicine 220 (6), e20221086, 2023 | 10 | 2023 |
The cell envelope of Staphylococcus aureus selectively controls the sorting of virulence factors. Nat Commun 12: 6193 X Zheng, G Marsman, KA Lacey, JR Chapman, C Goosmann, ... | 9 | 2021 |
Capsular polysaccharide is essential for the virulence of the antimicrobial-resistant pathogen Enterobacter hormaechei A St. John, AI Perault, SI Giacometti, AG Sommerfield, AL DuMont, ... Mbio 14 (2), e02590-22, 2023 | 7 | 2023 |
The tempo and mode of gene regulatory programs during bacterial infection G Avital, F Kuperwaser, AW Pountain, KA Lacey, EE Zwack, M Podkowik, ... Cell reports 41 (2), 2022 | 6 | 2022 |
Microbiome-independent effects of antibiotics in a murine model of nosocomial infections KA Lacey, S Gonzalez, F Yeung, G Putzel, M Podkowik, A Pironti, ... Mbio 13 (3), e01240-22, 2022 | 4 | 2022 |
Single-cell analysis of CX3CR1+ cells reveals a pathogenic role for BIRC5+ myeloid proliferating cells driven by Staphylococcus aureus leukotoxins DG Loredan, JC Devlin, KA Lacey, N Howard, Z Chen, EE Zwack, JD Lin, ... The Journal of Immunology, 2023 | 2 | 2023 |