A new view into the regulation of purine metabolism: the purinosome AM Pedley, SJ Benkovic Trends in biochemical sciences 42 (2), 141-154, 2017 | 530 | 2017 |
Spatial colocalization and functional link of purinosomes with mitochondria JB French, SA Jones, H Deng, AM Pedley, D Kim, CY Chan, H Hu, ... Science 351 (6274), 733-737, 2016 | 216 | 2016 |
Quantitative Analysis of Purine Nucleotides Indicates That Purinosomes Increase de Novo Purine Biosynthesis*♦ H Zhao, CR Chiaro, L Zhang, PB Smith, CY Chan, AM Pedley, RJ Pugh, ... Journal of Biological Chemistry 290 (11), 6705-6713, 2015 | 131 | 2015 |
Purinosome formation as a function of the cell cycle CY Chan, H Zhao, RJ Pugh, AM Pedley, J French, SA Jones, X Zhuang, ... Proceedings of the National Academy of Sciences 112 (5), 1368-1373, 2015 | 116 | 2015 |
Human de novo purine biosynthesis V Pareek, AM Pedley, SJ Benkovic Critical reviews in biochemistry and molecular biology 56 (1), 1-16, 2021 | 99 | 2021 |
Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria CY Chan, AM Pedley, D Kim, C Xia, X Zhuang, SJ Benkovic Proceedings of the National Academy of Sciences 115 (51), 13009-13014, 2018 | 69 | 2018 |
Hypoxia drives the assembly of the multienzyme purinosome complex C Doigneaux, AM Pedley, IN Mistry, M Papayova, SJ Benkovic, ... Journal of Biological Chemistry 295 (28), 9551-9566, 2020 | 41 | 2020 |
The purinosome: a case study for a mammalian metabolon AM Pedley, V Pareek, SJ Benkovic Annual review of biochemistry 91 (1), 89-106, 2022 | 37 | 2022 |
Replication protein A dynamically regulates monoubiquitination of proliferating cell nuclear antigen M Hedglin, M Aitha, A Pedley, SJ Benkovic Journal of biological chemistry 294 (13), 5157-5168, 2019 | 31 | 2019 |
Purine biosynthetic enzymes assemble into liquid-like condensates dependent on the activity of chaperone protein HSP90 AM Pedley, JP Boylan, CY Chan, EL Kennedy, M Kyoung, SJ Benkovic Journal of Biological Chemistry 298 (5), 2022 | 26 | 2022 |
Role of HSP90 in the Regulation of de Novo Purine Biosynthesis AM Pedley, GI Karras, X Zhang, S Lindquist, SJ Benkovic Biochemistry 57 (23), 3217-3221, 2018 | 23 | 2018 |
Flexibility of PCNA-protein interface accommodates differential binding partners AM Pedley, MA Lill, VJ Davisson PLoS One 9 (7), e102481, 2014 | 23 | 2014 |
Mapping post-translational modifications of de novo purine biosynthetic enzymes: implications for pathway regulation C Liu, GM Knudsen, AM Pedley, J He, JL Johnson, TM Yaron, LC Cantley, ... Journal of proteome research 18 (5), 2078-2087, 2019 | 18 | 2019 |
Conformational changes involving ammonia tunnel formation and allosteric control in GMP synthetase JC Oliver, R Gudihal, JW Burgner, AM Pedley, AT Zwierko, VJ Davisson, ... Archives of biochemistry and biophysics 545, 22-32, 2014 | 16 | 2014 |
Selective inhibition of STAT3 phosphorylation using a nuclear-targeted kinase inhibitor MD Bartolowits, W Brown, R Ali, AM Pedley, Q Chen, KE Harvey, ... ACS chemical biology 12 (9), 2371-2378, 2017 | 14 | 2017 |
The roles of molecular chaperones in regulating cell metabolism MJ Binder, AM Pedley FEBS letters 597 (13), 1681-1701, 2023 | 11 | 2023 |
Detecting purinosome metabolon formation with fluorescence microscopy AM Pedley, SJ Benkovic Protein Complex Assembly: Methods and Protocols, 279-289, 2018 | 9 | 2018 |
Identification of FAK substrate peptides via colorimetric screening of a one‐bead one‐peptide combinatorial library LA Witucki, LS Borowicz, AM Pedley, J Curtis‐Fisk, EG Kuszpit Journal of Peptide Science 21 (4), 302-311, 2015 | 3 | 2015 |
Evaluation of Proliferating Cell Nuclear Antigen as a Therapeutic Target in DNA Repair AM Pedley | | 2013 |