Current status and research strategies in tuberculosis drug development: miniperspective LG Dover, GD Coxon Journal of medicinal Chemistry 54 (18), 6157-6165, 2011 | 176 | 2011 |
Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria A Alahari, X Trivelli, Y Guérardel, LG Dover, GS Besra, JC Sacchettini, ... PloS one 2 (12), e1343, 2007 | 173 | 2007 |
Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice MH Mooney, S Fogarty, C Stevenson, AM Gallagher, P Palit, SA Hawley, ... British journal of pharmacology 153 (8), 1669-1677, 2008 | 98 | 2008 |
Characterisation of triterpenes and new phenolic lipids in Cameroonian propolis MN Kardar, T Zhang, GD Coxon, DG Watson, J Fearnley, V Seidel Phytochemistry 106, 156-163, 2014 | 81 | 2014 |
Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues GD Coxon, D Craig, RM Corrales, E Vialla, L Gannoun-Zaki, L Kremer PLoS One 8 (1), e53162, 2013 | 78 | 2013 |
Identification of 2-Aminothiazole-4-Carboxylate Derivatives Active against Mycobacterium tuberculosis H37Rv and the β-Ketoacyl-ACP Synthase mtFabH Q Al-Balas, NG Anthony, B Al-Jaidi, A Alnimr, G Abbott, AK Brown, ... PLoS One 4 (5), e5617, 2009 | 78 | 2009 |
Resistance to thiacetazone derivatives active against Mycobacterium abscessus involves mutations in the MmpL5 transcriptional repressor MAB_4384 I Halloum, A Viljoen, V Khanna, D Craig, C Bouchier, R Brosch, G Coxon, ... Antimicrobial agents and chemotherapy 61 (4), 10.1128/aac. 02509-16, 2017 | 68 | 2017 |
Identification of the benzodiazepines as a new class of antileishmanial agent RL Clark, KC Carter, AB Mullen, GD Coxon, G Owusu-Dapaah, ... Bioorganic & medicinal chemistry letters 17 (3), 624-627, 2007 | 66 | 2007 |
Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis V Bhowruth, AK Brown, RC Reynolds, GD Coxon, SP Mackay, ... Bioorganic & medicinal chemistry letters 16 (18), 4743-4747, 2006 | 61 | 2006 |
Benzylguanidines and other galegine analogues inducing weight loss in mice GD Coxon, BL Furman, AL Harvey, J McTavish, MH Mooney, M Arastoo, ... Journal of medicinal chemistry 52 (11), 3457-3463, 2009 | 34 | 2009 |
The synthesis of (11R, 12S)-lactobacillic acid and its enantiomer GD Coxon, JR Al-Dulayymi, MS Baird, S Knobl, E Roberts, DE Minnikin Tetrahedron: Asymmetry 14 (9), 1211-1222, 2003 | 34 | 2003 |
Strategies and challenges involved in the discovery of new chemical entities during early-stage tuberculosis drug discovery GD Coxon, CB Cooper, SH Gillespie, TD McHugh Journal of Infectious Diseases 205 (suppl_2), S258-S264, 2012 | 30 | 2012 |
The synthesis of both enantiomers of lactobacillic acid and mycolic acid analogues GD Coxon, S Knobl, E Roberts, MS Baird, JR Al Dulayymi, GS Besra, ... Tetrahedron letters 40 (36), 6689-6692, 1999 | 27 | 1999 |
Synthesis and properties of methyl 5-(1′ R, 2′ S)-(2-octadecylcycloprop-1-yl) pentanoate and other ω-19 chiral cyclopropane fatty acids and esters related to mycobacterial … GD Coxon, R Juma’a, C Morehouse, PJ Brennan, GS Besra, MS Baird, ... Chemistry and physics of lipids 127 (1), 35-46, 2004 | 16 | 2004 |
Synthesis of cis, cis-diunsaturated α-meromycolic acid by a palladium-catalysed alkyl–alkyl Negishi reaction G Berretta, GD Coxon Tetrahedron letters 53 (2), 214-216, 2012 | 7 | 2012 |
Facile synthesis of (Z)-tetracos-5-enoic acid and racemic cis-4-(2-octadecylcyclopropane-1-yl)-butanoic acid GD Coxon, JD Douglas, DE Minnikin Chemistry and physics of lipids 126 (1), 49-53, 2003 | 7 | 2003 |
Asymmetric and Regiospecific Synthesis of Isotopically Labelled Cyclopropane Fatty Acid (9R, 10S)-Dihydrosterculic Acid: Overcoming Spontaneous Protonation During Lithium … SWJ Shields, PH Buist, JM Manthorpe SynOpen 2 (02), 0168-0175, 2018 | 1 | 2018 |
Synthesis and crystal structures of 3-hydroxy-2, 4-dimethyl-2H-thiophen-5-one and 3-hydroxy-4-methyl-2H-thiophen-5-one A Nashawi, CP Lawson, MO Abdel-Sattar, JH Ter Horst, GD Coxon, ... Acta Crystallographica Section E: Crystallographic Communications 76 (7 …, 2020 | | 2020 |
Oral evidence to the International Development Committee G Coxon Department for International Development Summit, 2012 | | 2012 |
Written Evidence from TBD-UK, Dr Geoff Coxon G Coxon | | 2012 |