Elimination of toxic microsatellite repeat expansion RNA by RNA-targeting Cas9 R Batra, DA Nelles, E Pirie, SM Blue, RJ Marina, H Wang, IA Chaim, ... Cell 170 (5), 899-912. e10, 2017 | 291 | 2017 |
Pharmacologic modulation of RNA splicing enhances anti-tumor immunity SX Lu*, E De Neef*, JD Thomas*, E Sabio, B Rousseau, M Gigoux, ... Cell doi: 10.1016/j.cell.2021.05.038 (*equal contribution), 2021 | 166 | 2021 |
Intron retention induced by microsatellite expansions as a disease biomarker ŁJ Sznajder*, JD Thomas*, EM Carrell, T Reid, KN McFarland, JD Cleary, ... Proceedings of the National Academy of Sciences 115 (16), 4234-4239 (*equal …, 2018 | 109 | 2018 |
Disrupted prenatal RNA processing and myogenesis in congenital myotonic dystrophy JD Thomas, ŁJ Sznajder, O Bardhi, FN Aslam, ZP Anastasiadis, MM Scotti, ... Genes & development 31 (11), 1122-1133, 2017 | 92 | 2017 |
RNA isoform screens uncover the essentiality and tumor-suppressor activity of ultraconserved poison exons JD Thomas, JT Polaski, Q Feng, EJ De Neef, ER Hoppe, MV McSharry, ... Nature genetics 52 (1), 84-94, 2020 | 84 | 2020 |
Discovery of synthetic lethal and tumor suppressive paralog pairs in the human genome PCR Parrish*, JD Thomas*, S Kamlapurkar, A Gabel, RK Bradley, ... Cell Reports 36, 109597 (*equal contribution), 2021 | 71 | 2021 |
European corn borer (Ostrinia nubilalis) induced responses enhance susceptibility in maize NJ Dafoe, JD Thomas, PD Shirk, ME Legaspi, MM Vaughan, A Huffaker, ... PLoS One 8 (9), e73394, 2013 | 60 | 2013 |
Arp2/3 and Mena/VASP require profilin 1 for actin network assembly at the leading edge K Skruber, PV Warp, R Shklyarov, JD Thomas, MS Swanson, ... Current Biology 30 (14), 2651-2664. e5, 2020 | 57 | 2020 |
Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy MCG Iradi*, JC Triplett*, JD Thomas*, R Davila, AM Crown, H Brown, ... Scientific reports 8 (1), 1-15 (*equal contribution), 2018 | 47 | 2018 |
Aberrant myokine signaling in congenital myotonic dystrophy M Nakamori, K Hamanaka, JD Thomas, ET Wang, YK Hayashi, ... Cell reports 21 (5), 1240-1252, 2017 | 47 | 2017 |
The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy type 1 R Batra, DA Nelles, DM Roth, F Krach, CA Nutter, T Tadokoro, JD Thomas, ... Nature biomedical engineering 5 (2), 157-168, 2021 | 45 | 2021 |
Myotonic dystrophy and developmental regulation of RNA processing JD Thomas, O Ruan, ŁJ Sznajder, MS Swanson Comprehensive physiology 8 (2), 509-553, 2018 | 40* | 2018 |
Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells K North, S Benbarche, B Liu, J Pangallo, S Chen, M Stahl, JP Bewersdorf, ... Nature biotechnology 40 (7), 1103-1113, 2022 | 39 | 2022 |
MBNL splicing activity depends on RNA binding site structural context K Taylor, ŁJ Sznajder, P Cywoniuk, JD Thomas, MS Swanson, K Sobczak Nucleic acids research 46 (17), 9119-9133, 2018 | 38 | 2018 |
HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy M Li, Y Zhuang, R Batra, JD Thomas, M Li, CA Nutter, MM Scotti, ... Proceedings of the National Academy of Sciences 117 (10), 5472-5477, 2020 | 37 | 2020 |
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer A Vichas, AK Riley, NT Nkinsi, S Kamlapurkar, PCR Parrish, A Lo, F Duke, ... Nature communications 12 (1), 4789, 2021 | 27 | 2021 |
RBPMetaDB: a comprehensive annotation of mouse RNA-Seq datasets with perturbations of RNA-binding proteins J Li, SP Deng, J Vieira, J Thomas, V Costa, CS Tseng, F Ivankovic, ... Database 2018, bay054, 2018 | 4 | 2018 |
Multiplexed screening reveals how cancer-specific alternative polyadenylation shapes tumor growth in vivo AM Gabel, AE Belleville, JD Thomas, SA McKellar, TR Nicholas, T Banjo, ... Nature Communications 15 (1), 959, 2024 | 2 | 2024 |
pgMAP: a pipeline to enable guide RNA read mapping from dual-targeting CRISPR screens PCR Parrish, DJ Groso, JD Thomas, RK Bradley, AH Berger ArXiv, 2023 | | 2023 |