The synergic effect of vincristine and vorinostat in leukemia in vitro and in vivo MW Chao, MJ Lai, JP Liou, YL Chang, JC Wang, SL Pan, CM Teng Journal of hematology & oncology 8, 1-15, 2015 | 82 | 2015 |
Phenyl Benzenesulfonylhydrazides Exhibit Selective Indoleamine 2,3-Dioxygenase Inhibition with Potent in Vivo Pharmacodynamic Activity and Antitumor Efficacy SY Lin, TK Yeh, CC Kuo, JS Song, MF Cheng, FY Liao, MW Chao, ... Journal of Medicinal Chemistry 59 (1), 419-430, 2016 | 79 | 2016 |
α-Tomatine-Mediated Anti-Cancer Activity In Vitro and In Vivo through Cell Cycle- and Caspase-Independent Pathways MW Chao, CH Chen, YL Chang, CM Teng, SL Pan Public Library of Science 7 (9), e44093, 2012 | 55 | 2012 |
N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression S Mehndiratta, MH Lin, YW Wu, CH Chen, TY Wu, KH Chuang, MW Chao, ... European Journal of Medicinal Chemistry 185, 111725, 2020 | 46 | 2020 |
Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells MW Chao, TH Chen, HL Huang, YW Chang, WC HuangFu, YC Lee, ... Scientific reports 7 (1), 46134, 2017 | 40 | 2017 |
Non-epigenetic function of HDAC8 in regulating breast cancer stem cells by maintaining Notch1 protein stability MW Chao, PC Chu, HC Chuang, FH Shen, CC Chou, EC Hsu, LE Himmel, ... Oncotarget 7 (2), 1796, 2016 | 35 | 2016 |
Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo R Ojha, K Nepali, CH Chen, KH Chuang, TY Wu, TE Lin, KC Hsu, ... European Journal of Medicinal Chemistry 190, 112086, 2020 | 34 | 2020 |
Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status MW Chao, LH Chang, HJ Tu, CD Chang, MJ Lai, YY Chen, JP Liou, ... Clinical Epigenetics 11, 1-14, 2019 | 29 | 2019 |
A novel selective JAK2 inhibitor identified using pharmacological interactions TE Lin, WC HuangFu, MW Chao, TY Sung, CD Chang, YY Chen, ... Frontiers in pharmacology 9, 1379, 2018 | 29 | 2018 |
Integrin-linked kinase as a novel molecular switch of the IL-6-NF-κB signaling loop in breast cancer EC Hsu, SK Kulp, HL Huang, HJ Tu, MW Chao, YC Tseng, MC Yang, ... Carcinogenesis 37 (4), 430-442, 2016 | 28 | 2016 |
eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer MW Chao, LT Wang, CY Lai, XM Yang, YW Cheng, KH Lee, SL Pan, ... Oncotarget 6 (27), 24092, 2015 | 25 | 2015 |
The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells HJ Tu, YJ Lin, MW Chao, TY Sung, YW Wu, YY Chen, MH Lin, JP Liou, ... Clinical Epigenetics 10, 1-13, 2018 | 21 | 2018 |
A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo YW Wu, MW Chao, HJ Tu, LC Chen, KC Hsu, JP Liou, CR Yang, SC Yen, ... Oncogenesis 10 (5), 39, 2021 | 19 | 2021 |
MPT0G066, a novel anti-mitotic drug, induces JNK-independent mitotic arrest, JNK-mediated apoptosis and potentiates antineoplastic effect of cisplatin in ovarian cancer HL Huang, MW Chao, YC Li, LH Chang, CH Chen, MC Chen, CC Cheng, ... Scientific reports 6 (1), 31664, 2016 | 19 | 2016 |
Amide-tethered quinoline-resorcinol conjugates as a new class of HSP90 inhibitors suppressing the growth of prostate cancer cells K Nepali, MH Lin, MW Chao, SJ Peng, KC Hsu, TE Lin, MC Chen, MJ Lai, ... Bioorganic Chemistry 91, 103119, 2019 | 15 | 2019 |
Ring-opening of five-membered heterocycles conjugated 4-isopropylresorcinol scaffold-based benzamides as HSP90 inhibitors suppressing tumor growth in vitro and in vivo YM Liu, HJ Tu, CH Wu, MJ Lai, SC Yu, MW Chao, YW Wu, CM Teng, ... European Journal of Medicinal Chemistry 219, 113428, 2021 | 11 | 2021 |
Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach MW Chao, TE Lin, WC HuangFu, CD Chang, HJ Tu, LC Chen, SC Yen, ... Journal of Enzyme Inhibition and Medicinal Chemistry 36 (1), 98-108, 2021 | 10 | 2021 |
LTP-1, a novel antimitotic agent and Stat3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo HL Huang, MW Chao, CC Chen, CC Cheng, MC Chen, CF Lin, JP Liou, ... Scientific reports 6 (1), 27794, 2016 | 10 | 2016 |
Discovery of a novel cyclin-dependent kinase 8 inhibitor with an oxindole core for anti-inflammatory treatment TE Lin, CR Yang, CH Chou, JY Hsu, MW Chao, TY Sung, JH Hsieh, ... Biomedicine & Pharmacotherapy 146, 112459, 2022 | 9 | 2022 |
Identification and analysis of a selective DYRK1A inhibitor TE Lin, MW Chao, WC HuangFu, HJ Tu, ZX Peng, CJ Su, TY Sung, ... Biomedicine & Pharmacotherapy 146, 112580, 2022 | 8 | 2022 |