Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS LS Reinert, K Lopušná, H Winther, C Sun, MK Thomsen, R Nandakumar, ... Nature communications 7 (1), 13348, 2016 | 306 | 2016 |
Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses CK Holm, SH Rahbek, HH Gad, RO Bak, MR Jakobsen, Z Jiang, ... Nature communications 7 (1), 10680, 2016 | 228 | 2016 |
Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection MK Thomsen, R Nandakumar, D Stadler, A Malo, RM Valls, F Wang, ... Hepatology 64 (3), 746-759, 2016 | 170 | 2016 |
SOX9 Elevation in the Prostate Promotes Proliferation and Cooperates with PTEN Loss to Drive Tumor Formation MK Thomsen, L Ambroisine, S Wynn, KSE Cheah, CS Foster, G Fisher, ... Cancer research 70 (3), 979-987, 2010 | 168 | 2010 |
Regulation of steatohepatitis and PPARγ signaling by distinct AP-1 dimers SC Hasenfuss, L Bakiri, MK Thomsen, EG Williams, J Auwerx, EF Wagner Cell Metabolism 19 (1), 84-95, 2014 | 125 | 2014 |
Intracellular bacteria engage a STING–TBK1–MVB12b pathway to enable paracrine cGAS–STING signalling R Nandakumar, R Tschismarov, F Meissner, T Prabakaran, ... Nature microbiology 4 (4), 701-713, 2019 | 119 | 2019 |
β-Catenin Is Required for Prostate Development and Cooperates with Pten Loss to Drive Invasive Carcinoma JC Francis, MK Thomsen, MM Taketo, A Swain PLoS genetics 9 (1), e1003180, 2013 | 114 | 2013 |
Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation L Bakiri, R Hamacher, O Graña, A Guío-Carrión, R Campos-Olivas, ... Journal of Experimental Medicine 214 (5), 1387-1409, 2017 | 109 | 2017 |
Sox9 is required for prostate development MK Thomsen, CM Butler, MM Shen, A Swain Developmental biology 316 (2), 302-311, 2008 | 108 | 2008 |
STEEP mediates STING ER exit and activation of signaling B Zhang, R Nandakumar, LS Reinert, J Huang, A Laustsen, Z Gao, C Sun, ... Nature immunology 21 (8), 868-879, 2020 | 106 | 2020 |
An innate antiviral pathway acting before interferons at epithelial surfaces MB Iversen, LS Reinert, MK Thomsen, I Bagdonaite, R Nandakumar, ... Nature immunology 17 (2), 150-158, 2016 | 82 | 2016 |
Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production LS Reinert, AS Rashidi, DN Tran, G Katzilieris-Petras, AK Hvidt, M Gohr, ... The Journal of clinical investigation 131 (1), 2021 | 78 | 2021 |
The cGAS-STING pathway is a therapeutic target in a preclinical model of hepatocellular carcinoma MK Thomsen, MK Skouboe, C Boularan, F Vernejoul, T Lioux, SL Leknes, ... Oncogene 39 (8), 1652-1664, 2020 | 70 | 2020 |
The role of Sox9 in prostate development MK Thomsen, JC Francis, A Swain Differentiation 76 (6), 728-735, 2008 | 70 | 2008 |
JUNB/AP-1 controls IFN-γ during inflammatory liver disease MK Thomsen, L Bakiri, SC Hasenfuss, R Hamacher, L Martinez, ... The Journal of clinical investigation 123 (12), 5258-5268, 2013 | 66 | 2013 |
STING agonists enable antiviral cross-talk between human cells and confer protection against genital herpes in mice MK Skouboe, A Knudsen, LS Reinert, C Boularan, T Lioux, E Perouzel, ... PLoS pathogens 14 (4), e1006976, 2018 | 54 | 2018 |
Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic CJA Duncan, MK Skouboe, S Howarth, AK Hollensen, R Chen, ... Journal of Experimental Medicine 219 (6), e20212427, 2022 | 52 | 2022 |
A truncated reverse transcriptase enhances prime editing by split AAV vectors Z Gao, S Ravendran, NS Mikkelsen, J Haldrup, H Cai, X Ding, ... Molecular Therapy 30 (9), 2942-2951, 2022 | 51 | 2022 |
Dominant-negative SERPING1 variants cause intracellular retention of C1 inhibitor in hereditary angioedema D Haslund, LB Ryø, SS Majidi, I Rose, KA Skipper, T Fryland, AB Bohn, ... The Journal of Clinical Investigation 129 (1), 388-405, 2019 | 50 | 2019 |
Loss of JUNB/AP-1 promotes invasive prostate cancer MK Thomsen, L Bakiri, SC Hasenfuss, H Wu, M Morente, EF Wagner Cell Death & Differentiation 22 (4), 574-582, 2015 | 49 | 2015 |