| Versatility of PRMT5-induced methylation in growth control and development V Karkhanis, YJ Hu, RA Baiocchi, AN Imbalzano, S Sif Trends in biochemical sciences 36 (12), 633-641, 2011 | 311 | 2011 |
| Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation L Alinari, KV Mahasenan, F Yan, V Karkhanis, JH Chung, EM Smith, ... Blood, The Journal of the American Society of Hematology 125 (16), 2530-2543, 2015 | 167 | 2015 |
| Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase δ catalytic subunit gene, POLD1 V Karkhanis, L Wang, S Tae, YJ Hu, AN Imbalzano, S Sif Journal of Biological Chemistry 287 (35), 29801-29814, 2012 | 156 | 2012 |
| Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor … J Chung, V Karkhanis, S Tae, F Yan, P Smith, LW Ayers, C Agostinelli, ... Journal of Biological Chemistry 288 (49), 35534-35547, 2013 | 129 | 2013 |
| PRMT5–PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells YK Banasavadi-Siddegowda, L Russell, E Frair, VA Karkhanis, T Relation, ... Oncogene 36 (2), 263-274, 2017 | 123 | 2017 |
| Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes S Tae, V Karkhanis, K Velasco, M Yaneva, H Erdjument-Bromage, ... Nucleic acids research 39 (13), 5424-5438, 2011 | 112 | 2011 |
| Amino Acid Toxicities of Escherichia coli That Are Prevented by Leucyl-tRNA Synthetase Amino Acid Editing VA Karkhanis, AP Mascarenhas, SA Martinis Journal of bacteriology 189 (23), 8765-8768, 2007 | 92 | 2007 |
| Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/β-catenin and AKT/GSK3β proliferative signaling J Chung, V Karkhanis, RA Baiocchi, S Sif Journal of Biological Chemistry 294 (19), 7692-7710, 2019 | 81 | 2019 |
| PRMT5-selective inhibitors suppress inflammatory T cell responses and experimental autoimmune encephalomyelitis LM Webb, SA Amici, KA Jablonski, H Savardekar, AR Panfil, L Li, W Zhou, ... The Journal of Immunology 198 (4), 1439-1451, 2017 | 76 | 2017 |
| A viable amino acid editing activity in the leucyl-tRNA synthetase CP1-splicing domain is not required in the yeast mitochondria VA Karkhanis, MT Boniecki, K Poruri, SA Martinis Journal of Biological Chemistry 281 (44), 33217-33225, 2006 | 46 | 2006 |
| Protein arginine methyltransferase 5 represses tumor suppressor miRNAs that down-regulate CYCLIN D1 and c-MYC expression in aggressive B-cell lymphoma V Karkhanis, L Alinari, HG Ozer, J Chung, X Zhang, S Sif, RA Baiocchi Journal of Biological Chemistry 295 (5), 1165-1180, 2020 | 40 | 2020 |
| Mechanistic basis and efficacy of targeting the β-catenin–TCF7L2–JMJD6–c-Myc axis to overcome resistance to BET inhibitors DT Saenz, W Fiskus, CP Mill, D Perera, T Manshouri, BH Lara, ... Blood, The Journal of the American Society of Hematology 135 (15), 1255-1269, 2020 | 36 | 2020 |
| Transducin b-like protein 1 controls multiple oncogenic networks in diffuse large B-cell lymphoma Y Youssef, V Karkhanis, WK Chan, F Jeney, A Canella, X Zhang, S Sloan, ... haematologica 106 (11), 2927, 2021 | 8 | 2021 |
| Developing a novel class of drug to inhibit protein arginine methyltransferase 5 (PRMT5) enzyme dysregulation in mantle cell lymphoma F Yan, P Smith, L Alinari, J Ryu, B Yu, V Karkhanis, S Tae, JT Patton, ... Blood 118 (21), 595, 2011 | 3 | 2011 |
| Pre-clinical efficacy of co-treatment with KDM1A (LSD1) inhibitor and ruxolitinib or BET inhibitor against post-MPN-sAML blast progenitor cells W Fiskus, CP Mill, V Karkhanis, BH Lara, P Bose, L Masarova, TM Kadia, ... Blood 134, 1274, 2019 | 2 | 2019 |
| Protein arginine methyltransferase 5 regulates WNT/β-catenin target gene expression in at multiple levels J Chung, V Karkhanis, S Said, RA Baiocchi Blood 128 (22), 4106, 2016 | 2 | 2016 |
| Protein Arginine Methyltransferase 5 Directly Targets and Epigenetically Silences microRNAs miR33b and miR96 to Support Constitutive Cyclin D1 Activity in Non-Hodgkin’s Lymphoma V Karkhanis, O Elemento, M Di Liberto, S Chen-Kiang, S Sif, RA Baiocchi Blood 124 (21), 60, 2014 | 2 | 2014 |
| Mechanistic Basis and Efficacy of Targeting β-Catenin-TCF7L2-JMJD6-MYC Axis to Overcome Resistance to BET Inhibitors CP Mill, W Fiskus, DT Saenz, BH Lara, V Karkhanis, T Manshouri, I Bhalla, ... Blood 134, 538, 2019 | 1 | 2019 |
| PRMT5 Targets Tumor Suppressor Micro RNAs to Regulate Cyclin D1 and c-MYC in Mantle Cell Lymphoma V Karkhanis, L Alinari, B Mundy, M Caliguri, S Chen-Kiang, O Elemento, ... Blood 128 (22), 2937, 2016 | 1 | 2016 |
| Transducin oncogenic networks b-like protein in diffuse 1 controls largemultiple B-cell lymphoma Y Youssef, V Karkhanis, WK Chan, F Jeney, A Canella, X Zhang, S Sloan, ... Haematologica 106 (11), 2927-2939, 2021 | | 2021 |
