The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency A Bertero, S Brown, P Madrigal, A Osnato, D Ortmann, L Yiangou, ... Nature 555 (7695), 256-259, 2018 | 329 | 2018 |
Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids F Sampaziotis, AW Justin, OC Tysoe, S Sawiak, EM Godfrey, SS Upponi, ... Nature medicine 23 (8), 954-963, 2017 | 282 | 2017 |
Optimized inducible shRNA and CRISPR/Cas9 platforms for in vitro studies of human development using hPSCs A Bertero, M Pawlowski, D Ortmann, K Snijders, L Yiangou, ... Development 143 (23), 4405-4418, 2016 | 92 | 2016 |
Human pluripotent stem cell-derived endoderm for modeling development and clinical applications L Yiangou, ADB Ross, KJ Goh, L Vallier Cell Stem Cell 22 (4), 485-499, 2018 | 72 | 2018 |
Generation, functional analysis and applications of isogenic three-dimensional self-aggregating cardiac microtissues from human pluripotent stem cells G Campostrini, V Meraviglia, E Giacomelli, RWJ van Helden, L Yiangou, ... Nature protocols 16 (4), 2213-2256, 2021 | 71 | 2021 |
Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors SJ Horton, G Giotopoulos, H Yun, S Vohra, O Sheppard, ... Nature cell biology 19 (9), 1093-1104, 2017 | 68 | 2017 |
Method to synchronize cell cycle of human pluripotent stem cells without affecting their fundamental characteristics L Yiangou, RA Grandy, CM Morell, RA Tomaz, A Osnato, J Kadiwala, ... Stem cell reports 12 (1), 165-179, 2019 | 54 | 2019 |
Cryopreservation of human pluripotent stem cell-derived cardiomyocytes is not detrimental to their molecular and functional properties L van den Brink, KO Brandão, L Yiangou, MPH Mol, C Grandela, ... Stem cell research 43, 101698, 2020 | 36 | 2020 |
Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations J Pei, M Schuldt, E Nagyova, Z Gu, S El Bouhaddani, L Yiangou, ... Clinical epigenetics 13, 1-20, 2021 | 30 | 2021 |
Using cardiovascular cells from human pluripotent stem cells for COVID-19 research: why the heart fails L Yiangou, RP Davis, CL Mummery Stem cell reports 16 (3), 385-397, 2021 | 30 | 2021 |
Maturation of hiPSC-derived cardiomyocytes promotes adult alternative splicing of SCN5A and reveals changes in sodium current associated with cardiac arrhythmia G Campostrini, G Kosmidis, D Ward-van Oostwaard, RP Davis, L Yiangou, ... Cardiovascular research 119 (1), 167-182, 2023 | 26 | 2023 |
Cell cycle regulators control mesoderm specification in human pluripotent stem cells L Yiangou, RA Grandy, A Osnato, D Ortmann, S Sinha, L Vallier Journal of Biological Chemistry 294 (47), 17903-17914, 2019 | 23 | 2019 |
A Stem Cell Strategy Identifies Glycophorin C as a Major Erythrocyte Receptor for the Rodent Malaria Parasite Plasmodium berghei L Yiangou, R Montandon, K Modrzynska, B Rosen, W Bushell, C Hale, ... Plos one 11 (6), e0158238, 2016 | 23 | 2016 |
STRAIGHT-IN enables high-throughput targeting of large DNA payloads in human pluripotent stem cells A Blanch-Asensio, C Grandela, KO Brandão, T de Korte, H Mei, ... Cell Reports Methods 2 (10), 2022 | 21 | 2022 |
Conditional manipulation of gene function in human cells with optimized inducible shRNA A Bertero, L Yiangou, S Brown, D Ortmann, M Pawlowski, L Vallier Current Protocols in Stem Cell Biology 44 (1), 5C. 4.1-5C. 4.48, 2018 | 12 | 2018 |
Beneficial effects of chronic mexiletine treatment in a human model of SCN5A overlap syndrome G Nasilli, L Yiangou, C Palandri, E Cerbai, RP Davis, AO Verkerk, ... Europace 25 (6), euad154, 2023 | 8 | 2023 |
Optogenetic reporters delivered as mRNA facilitate repeatable action potential and calcium handling assessment in human iPSC-derived cardiomyocytes L Yiangou, A Blanch-Asensio, T de Korte, DC Miller, BJ van Meer, ... Stem Cells 40 (7), 655-668, 2022 | 7 | 2022 |
The linkage phase of the polymorphism KCNH2-K897T influences the electrophysiological phenotype in hiPSC models of LQT2 L van den Brink, KO Brandão, L Yiangou, A Blanch-Asensio, MPH Mol, ... Frontiers in physiology 12, 755642, 2021 | 5 | 2021 |
CRISPR/Cas9-mediated introduction of specific heterozygous mutations in human induced pluripotent stem cells KO Brandão, C Grandela, L Yiangou, CL Mummery, RP Davis Induced Pluripotent Stem (iPS) Cells: Methods and Protocols, 531-557, 2021 | 5 | 2021 |
Gain of chromosome region 1q31. 3 in human iPSCs confers growth advantage and alters contraction in derivative cardiomyocytes KO Brandao, V Meraviglia, D Salvatori, X Cao, LP Sala, L Yiangou, ... BioRxiv, 2023.12. 11.571144, 2023 | 1 | 2023 |