| Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism H Ying, AC Kimmelman, CA Lyssiotis, S Hua, GC Chu, ... Cell 149 (3), 656-670, 2012 | 2024 | 2012 |
| Genetics and biology of pancreatic ductal adenocarcinoma AF Hezel, AC Kimmelman, BZ Stanger, N Bardeesy, RA DePinho Genes & development 20 (10), 1218-1249, 2006 | 1569 | 2006 |
| Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping DR Borger, KK Tanabe, KC Fan, HU Lopez, VR Fantin, KS Straley, ... The oncologist 17 (1), 72-79, 2012 | 826 | 2012 |
| Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer N Bardeesy, K Cheng, JH Berger, GC Chu, J Pahler, P Olson, AF Hezel, ... Genes & development 20 (22), 3130-3146, 2006 | 792 | 2006 |
| Both p16Ink4a and the p19Arf-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse N Bardeesy, AJ Aguirre, GC Chu, K Cheng, LV Lopez, AF Hezel, B Feng, ... Proceedings of the National Academy of Sciences 103 (15), 5947-5952, 2006 | 744 | 2006 |
| Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study AX Zhu, DV Sahani, DG Duda, E di Tomaso, M Ancukiewicz, OA Catalano, ... Journal of clinical oncology 27 (18), 3027-3035, 2009 | 552 | 2009 |
| Durvalumab with or without tremelimumab for patients with metastatic pancreatic ductal adenocarcinoma: a phase 2 randomized clinical trial EM O’Reilly, DY Oh, N Dhani, DJ Renouf, MA Lee, W Sun, G Fisher, ... JAMA oncology 5 (10), 1431-1438, 2019 | 537 | 2019 |
| Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation N Bardeesy, M Sinha, AF Hezel, S Signoretti, NA Hathaway, ... Nature 419 (6903), 162-167, 2002 | 485 | 2002 |
| Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer SK Saha, CA Parachoniak, KS Ghanta, J Fitamant, KN Ross, MS Najem, ... Nature 513 (7516), 110-114, 2014 | 482 | 2014 |
| Current management of gallbladder carcinoma AX Zhu, TS Hong, AF Hezel, DA Kooby The oncologist 15 (2), 168-181, 2010 | 433 | 2010 |
| Stromal biology of pancreatic cancer GC Chu, AC Kimmelman, AF Hezel, RA DePinho Journal of cellular biochemistry 101 (4), 887-907, 2007 | 429 | 2007 |
| Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer BM Wolpin, AF Hezel, T Abrams, LS Blaszkowsky, JA Meyerhardt, ... Journal of Clinical Oncology 27 (2), 193-198, 2009 | 342 | 2009 |
| K-ras activation generates an inflammatory response in lung tumors H Ji, AM Houghton, TJ Mariani, S Perera, CB Kim, R Padera, G Tonon, ... Oncogene 25 (14), 2105-2112, 2006 | 309 | 2006 |
| LKB1; linking cell structure and tumor suppression AF Hezel, N Bardeesy Oncogene 27 (55), 6908-6919, 2008 | 278 | 2008 |
| Systemic therapy for biliary tract cancers AF Hezel, AX Zhu The oncologist 13 (4), 415-423, 2008 | 261 | 2008 |
| Beyond microsatellite testing: assessment of tumor mutational burden identifies subsets of colorectal cancer who may respond to immune checkpoint inhibition DA Fabrizio, TJ George Jr, RF Dunne, G Frampton, J Sun, K Gowen, ... Journal of gastrointestinal oncology 9 (4), 610, 2018 | 239 | 2018 |
| PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB–cytokine network H Ying, KG Elpek, A Vinjamoori, SM Zimmerman, GC Chu, H Yan, ... Cancer discovery 1 (2), 158-169, 2011 | 236 | 2011 |
| Genetics of biliary tract cancers and emerging targeted therapies AF Hezel, V Deshpande, AX Zhu Journal of Clinical Oncology 28 (21), 3531-3540, 2010 | 233 | 2010 |
| KrasG12D and p53 Mutation Cause Primary Intrahepatic Cholangiocarcinoma MR O'Dell, J Li Huang, CL Whitney-Miller, V Deshpande, P Rothberg, ... Cancer research 72 (6), 1557-1567, 2012 | 215 | 2012 |
| Dual inactivation of RB and p53 pathways in RAS-induced melanomas N Bardeesy, BC Bastian, A Hezel, D Pinkel, RA DePinho, L Chin Molecular and cellular biology, 2001 | 210 | 2001 |
