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Nicolas H. Thomä
Nicolas H. Thomä
Paternot Chair in Cancer Research (Institute for Experimental Cancer Research) at EPFL
在 epfl.ch 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide
ES Fischer, K Böhm, JR Lydeard, H Yang, MB Stadler, S Cavadini, ...
Nature 512 (7512), 49-53, 2014
10482014
BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure
H Yang, PD Jeffrey, J Miller, E Kinnucan, Y Sun, NH Thoma, N Zheng, ...
Science 297 (5588), 1837-1848, 2002
8842002
Histone methylation by PRC2 is inhibited by active chromatin marks
FW Schmitges, AB Prusty, M Faty, A Stützer, GM Lingaraju, J Aiwazian, ...
Molecular cell 42 (3), 330-341, 2011
8072011
Determinants and dynamics of genome accessibility
O Bell, VK Tiwari, NH Thomä, D Schübeler
Nature Reviews Genetics 12 (8), 554-564, 2011
5592011
Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase
G Petzold, ES Fischer, NH Thomä
Nature 532 (7597), 127-130, 2016
5552016
Structural basis of UV DNA-damage recognition by the DDB1–DDB2 complex
A Scrima, R Koníčková, BK Czyzewski, Y Kawasaki, PD Jeffrey, ...
Cell 135 (7), 1213-1223, 2008
5022008
The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation
ES Fischer, A Scrima, K Böhm, S Matsumoto, GM Lingaraju, M Faty, ...
Cell 147 (5), 1024-1039, 2011
4792011
Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN
QL Sievers, G Petzold, RD Bunker, A Renneville, M Słabicki, BJ Liddicoat, ...
Science 362 (6414), eaat0572, 2018
4252018
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
M Słabicki, Z Kozicka, G Petzold, YD Li, M Manojkumar, RD Bunker, ...
Nature 585 (7824), 293-297, 2020
3082020
Rational discovery of molecular glue degraders via scalable chemical profiling
C Mayor-Ruiz, S Bauer, M Brand, Z Kozicka, M Siklos, H Imrichova, ...
Nature chemical biology 16 (11), 1199-1207, 2020
2622020
Structure of the SWI2/SNF2 chromatin-remodeling domain of eukaryotic Rad54
NH Thomä, BK Czyzewski, AA Alexeev, AV Mazin, SC Kowalczykowski, ...
Nature structural & molecular biology 12 (4), 350-356, 2005
2512005
Crystal structure of the human COP9 signalosome
GM Lingaraju, RD Bunker, S Cavadini, D Hess, U Hassiepen, M Renatus, ...
Nature 512 (7513), 161-165, 2014
2442014
Cullin–RING ubiquitin E3 ligase regulation by the COP9 signalosome
S Cavadini, ES Fischer, RD Bunker, A Potenza, GM Lingaraju, KN Goldie, ...
Nature 531 (7596), 598-603, 2016
2172016
Structural mechanism of cGAS inhibition by the nucleosome
GR Pathare, A Decout, S Glück, S Cavadini, K Makasheva, R Hovius, ...
Nature 587 (7835), 668-672, 2020
2162020
Rif1 controls DNA replication timing in yeast through the PP1 phosphatase Glc7
S Mattarocci, M Shyian, L Lemmens, P Damay, DM Altintas, T Shi, ...
Cell reports 7 (1), 62-69, 2014
2062014
Mechanisms of OCT4-SOX2 motif readout on nucleosomes
AK Michael, RS Grand, L Isbel, S Cavadini, Z Kozicka, G Kempf, ...
Science 368 (6498), 1460-1465, 2020
2032020
Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes
V Ostapcuk, F Mohn, SH Carl, A Basters, D Hess, V Iesmantavicius, ...
Nature 557 (7707), 739-743, 2018
1792018
Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase
O Pylypenko, A Rak, R Reents, A Niculae, V Sidorovitch, MD Cioaca, ...
Molecular cell 11 (2), 483-494, 2003
1762003
Structure of doubly prenylated Ypt1: GDI complex and the mechanism of GDI‐mediated Rab recycling
O Pylypenko, A Rak, T Durek, S Kushnir, BE Dursina, NH Thomae, ...
The EMBO journal 25 (1), 13-23, 2006
1492006
Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases
KM Doherty, JA Sommers, MD Gray, JW Lee, C von Kobbe, NH Thoma, ...
Journal of Biological Chemistry 280 (33), 29494-29505, 2005
1492005
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