A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models Y Zhou, P Castonguay, EH Sidhom, AR Clark, M Dvela-Levitt, S Kim, ... Science 358 (6368), 1332-1336, 2017 | 149 | 2017 |
Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy M Dvela-Levitt, M Kost-Alimova, M Emani, E Kohnert, R Thompson, ... Cell 178 (3), 521-535. e23, 2019 | 147 | 2019 |
Endogenous ouabain regulates cell viability M Dvela, H Rosen, HC Ben-Ami, D Lichtstein American Journal of Physiology-Cell Physiology 302 (2), C442-C452, 2012 | 94 | 2012 |
Diverse biological responses to different cardiotonic steroids M Dvela, H Rosen, T Feldmann, M Nesher, D Lichtstein Pathophysiology 14 (3-4), 159-166, 2007 | 82 | 2007 |
Physiological roles of endogenous ouabain in normal rats M Nesher, M Dvela, VU Igbokwe, H Rosen, D Lichtstein American Journal of Physiology-Heart and Circulatory Physiology 297 (6 …, 2009 | 67 | 2009 |
Ouabain attenuates cardiotoxicity induced by other cardiac steroids M Nesher, U Shpolansky, N Viola, M Dvela, N Buzaglo, HC Ben‐Ami, ... British journal of pharmacology 160 (2), 346-354, 2010 | 45 | 2010 |
A high-content screen for mucin-1-reducing compounds identifies fostamatinib as a candidate for rapid repurposing for acute lung injury M Kost-Alimova, EH Sidhom, A Satyam, BT Chamberlain, M Dvela-Levitt, ... Cell Reports Medicine 1 (8), 2020 | 43 | 2020 |
Reduction in maternal circulating ouabain impairs offspring growth and kidney development M Dvela-Levitt, HCB Ami, H Rosen, A Ornoy, D Hochner-Celnikier, ... Journal of the American Society of Nephrology 26 (5), 1103-1114, 2015 | 36 | 2015 |
Ouabain improves functional recovery following traumatic brain injury M Dvela-Levitt, HCB Ami, H Rosen, E Shohami, D Lichtstein Journal of neurotrauma 31 (23), 1942-1947, 2014 | 36 | 2014 |
A high content screen for mucin-1-reducing compounds identifies fostamatinib as a candidate for rapid repurposing for acute lung injury during the COVID-19 pandemic M Alimova, EH Sidhom, A Satyam, M Dvela-Levitt, M Melanson, ... bioRxiv, 2020 | 20 | 2020 |
Endogenous ouabain‐like compounds in locus coeruleus modulate rapid eye movement sleep in rats MK Jaiswal, M Dvela, D Lichtstein, BN Mallick Journal of sleep research 19 (1p2), 183-191, 2010 | 18 | 2010 |
Lysine trimethylation regulates 78-kDa glucose-regulated protein proteostasis during endoplasmic reticulum stress J Sieber, N Wieder, M Ostrosky-Frid, M Dvela-Levitt, O Aygün, ND Udeshi, ... Journal of Biological Chemistry 292 (46), 18878-18885, 2017 | 14 | 2017 |
Cardenolides and bufadienolides as hormones: what is missing? D Lichtstein, H Rosen, M Dvela American Journal of Physiology-Renal Physiology, 2012 | 13 | 2012 |
A rare kidney disease to cure them all? towards mechanism-based therapies for proteinopathies M Dvela-Levitt, JL Shaw, A Greka Trends in Molecular Medicine 27 (4), 394-409, 2021 | 10 | 2021 |
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity N Wieder, JC Fried, C Kim, EH Sidhom, MR Brown, JL Marshall, ... Cell metabolism 35 (5), 887-905. e11, 2023 | 7 | 2023 |
Involvement of the Na+, K+-ATPase α1 Isoform and Endogenous Cardiac Steroids in Depression- and Manic-like Behaviors N Horesh, I Pelov, I Pogodin, H Zannadeh, H Rosen, AL Mikhrina, ... International Journal of Molecular Sciences 25 (3), 1644, 2024 | 1 | 2024 |
Agents for reversing toxic proteinopathies A Greka, M Dvela-Levitt, M Alimova, E Lander, TR Golub, F Wagner, ... US Patent 11,207,278, 2021 | 1 | 2021 |
Agents for reversing toxic proteinopathies A Greka, M Dvela-Levitt, M Alimova, E Lander, TR Golub, F Wagner, ... US Patent App. 17/494,824, 2022 | | 2022 |
Agents for reversing toxic proteinopathies A Greka, M Dvela-Levitt, M Alimova, E Lander, TR Golub, F Wagner, ... US Patent App. 17/494,830, 2022 | | 2022 |
Elucidation of a novel mechanism for faulty protein retention and a therapeutic strategy for facilitated lysosomal removal M Dvela‐Levitt, M Alimova, E Kohnert, M Emani, E Sidhom, A Bleyer, ... The FASEB Journal 35, 2021 | | 2021 |