Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain N Maphis, G Xu, ON Kokiko-Cochran, S Jiang, A Cardona, RM Ransohoff, ... Brain 138 (6), 1738-1755, 2015 | 502 | 2015 |
Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events K Bhaskar, N Maphis, G Xu, NH Varvel, ON Kokiko-Cochran, JP Weick, ... Neurobiology of disease 62, 273-285, 2014 | 173 | 2014 |
Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential S Chauhan, Z Ahmed, SB Bradfute, J Arko-Mensah, MA Mandell, ... Nature communications 6 (1), 8620, 2015 | 152 | 2015 |
Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology N Maphis, S Jiang, G Xu, ON Kokiko-Cochran, SM Roy, LJ Van Eldik, ... Alzheimer's research & therapy 8, 1-15, 2016 | 106 | 2016 |
Loss of tau rescues inflammation-mediated neurodegeneration N Maphis, G Xu, ON Kokiko-Cochran, AE Cardona, RM Ransohoff, ... Frontiers in neuroscience 9, 196, 2015 | 92 | 2015 |
Hypoxia promotes tau hyperphosphorylation with associated neuropathology in vascular dysfunction L Raz, K Bhaskar, J Weaver, S Marini, Q Zhang, JF Thompson, ... Neurobiology of disease 126, 124-136, 2019 | 76 | 2019 |
Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88-and NLRP3-ASC-inflammasome pathway S Jiang, NM Maphis, J Binder, D Chisholm, L Weston, W Duran, ... Cell reports 36 (12), 2021 | 51 | 2021 |
Qß Virus-like particle-based vaccine induces robust immunity and protects against tauopathy NM Maphis, J Peabody, E Crossey, S Jiang, FA Jamaleddin Ahmad, ... npj Vaccines 4 (1), 26, 2019 | 38 | 2019 |
Whole genome expression analysis in a mouse model of tauopathy identifies MECP2 as a possible regulator of tau pathology NM Maphis, S Jiang, J Binder, C Wright, B Gopalan, BT Lamb, K Bhaskar Frontiers in molecular neuroscience 10, 69, 2017 | 31 | 2017 |
Photoreceptor degeneration, azoospermia, leukoencephalopathy, and abnormal RPE cell function in mice expressing an early stop mutation in CLCN2 MM Edwards, CM de Evsikova, GB Collin, E Gifford, J Wu, WL Hicks, ... Investigative ophthalmology & visual science 51 (6), 3264-3272, 2010 | 30 | 2010 |
Machine learning prediction and tau-based screening identifies potential Alzheimer’s disease genes relevant to immunity J Binder, O Ursu, C Bologa, S Jiang, N Maphis, S Dadras, D Chisholm, ... Communications Biology 5 (1), 125, 2022 | 29 | 2022 |
Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy SM Bemiller, NM Maphis, SV Formica, GN Wilson, CM Miller, G Xu, ... Journal of Neuroinflammation 15, 1-11, 2018 | 19 | 2018 |
The development, but not expression, of alcohol front‐loading in C57BL/6J mice maintained on LabDiet 5001 is abolished by maintenance on Teklad 2920x rodent diet NM Maphis, RT Huffman, DN Linsenbardt Alcoholism: Clinical and Experimental Research 46 (7), 1321-1330, 2022 | 12 | 2022 |
Selective In Vitro and Ex Vivo Staining of Brain Neurofibrillary Tangles and Amyloid Plaques by Novel Ethylene Ethynylene-Based Optical Sensors FA Monge, AM Fanni, PL Donabedian, J Hulse, NM Maphis, S Jiang, ... Biosensors 13 (2), 151, 2023 | 1 | 2023 |
Binding-Activated Superradiant Probes for Amyloid in Solution and Tissue P Donabedian, N Maphis, S Jiang, K Bhaskar, D Whitten, E Chi Biophysical Journal 110 (3), 554a, 2016 | 1 | 2016 |
Tau vaccines differentially target tau pathologies in Alzheimer’s disease and primary tauopathies JP Hulse, M Whelpley, NM Maphis, J Peabody, B Chackerian, K Bhaskar Alzheimer's Association International Conference, 2024 | | 2024 |
Immunotherapy compositions and methods for treatment of tauopathy and transgenic mouse K Bhaskar, N Maphis, DS Peabody, B Chackerian, J Peabody, E Crossey US Patent App. 18/402,899, 2024 | | 2024 |
Virus-like particle (VLP)-based vaccine targeting tau phosphorylated at Ser396/Ser404 (PHF1) site outperforms phosphorylated S199/S202 (AT8) site in reducing tau pathology and … K Bhaskar, J Hulse, N Maphis, J Peabody, B Chackerian | | 2024 |
Virus-like particle (VLP)-based vaccine targeting tau phosphorylated at Ser396/Ser404 (PHF1) site outperforms phosphorylated S199/S202 (AT8) site in reducing tau pathology and … JP Hulse, NM Maphis, J Peabody, B Chackerian, K Bhaskar bioRxiv, 2024.04. 05.588338, 2024 | | 2024 |
Alcohol Consumption During Early Adulthood in a Preclinical Mouse Model of Alzheimer’s Disease Leads to Gait Impairments, Dysregulated Circadian Rhythm, Alterations in … NM Maphis, D Furlano, SA David, DN Linsebardt | | 2023 |