CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity ML Burr, CE Sparbier, YC Chan, JC Williamson, K Woods, PA Beavis, ... Nature 549 (7670), 101-105, 2017 | 752 | 2017 |
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain J Marschallinger, T Iram, M Zardeneta, SE Lee, B Lehallier, MS Haney, ... Nature neuroscience 23 (2), 194-208, 2020 | 704 | 2020 |
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions K Han, EE Jeng, GT Hess, DW Morgens, A Li, MC Bassik Nature biotechnology 35 (5), 463-474, 2017 | 496 | 2017 |
Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes DW Morgens, RM Deans, A Li, MC Bassik Nature biotechnology 34 (6), 634-636, 2016 | 434 | 2016 |
Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens DW Morgens, M Wainberg, EA Boyle, O Ursu, CL Araya, CK Tsui, ... Nature communications 8 (1), 15178, 2017 | 341 | 2017 |
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains JV Pluvinage, MS Haney, BAH Smith, J Sun, T Iram, L Bonanno, L Li, ... Nature 568 (7751), 187-192, 2019 | 335 | 2019 |
CRISPR–Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity NJ Kramer, MS Haney, DW Morgens, A Jovičić, J Couthouis, A Li, J Ousey, ... Nature genetics 50 (4), 603-612, 2018 | 223 | 2018 |
Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification RM Deans, DW Morgens, A Ökesli, S Pillay, MA Horlbeck, M Kampmann, ... Nature chemical biology 12 (5), 361-366, 2016 | 175 | 2016 |
Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens MS Haney, CJ Bohlen, DW Morgens, JA Ousey, AA Barkal, CK Tsui, ... Nature genetics 50 (12), 1716-1727, 2018 | 163 | 2018 |
A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies DK Breslow, S Hoogendoorn, AR Kopp, DW Morgens, BK Vu, ... Nature genetics 50 (3), 460-471, 2018 | 158 | 2018 |
Genome-wide CRISPR analysis identifies substrate-specific conjugation modules in ER-associated degradation DE Leto, DW Morgens, L Zhang, CP Walczak, JE Elias, MC Bassik, ... Molecular cell 73 (2), 377-389. e11, 2019 | 119 | 2019 |
CRISPR-Cas9 screens identify the RNA helicase DDX3X as a repressor of C9ORF72 (GGGGCC) n repeat-associated non-AUG translation W Cheng, S Wang, Z Zhang, DW Morgens, LR Hayes, S Lee, B Portz, ... Neuron 104 (5), 885-898. e8, 2019 | 118 | 2019 |
Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements J Tycko, M Wainberg, GK Marinov, O Ursu, GT Hess, BK Ego, Aradhana, ... Nature communications 10 (1), 4063, 2019 | 106 | 2019 |
CRISPR-Cas9 screens identify regulators of antibody–drug conjugate toxicity CK Tsui, RM Barfield, CR Fischer, DW Morgens, A Li, BAH Smith, ... Nature chemical biology 15 (10), 949-958, 2019 | 66 | 2019 |
Systematic identification of regulators of oxidative stress reveals non-canonical roles for peroxisomal import and the pentose phosphate pathway MM Dubreuil, DW Morgens, K Okumoto, M Honsho, K Contrepois, ... Cell reports 30 (5), 1417-1433. e7, 2020 | 58 | 2020 |
Zmat3 is a key splicing regulator in the p53 tumor suppression program KT Bieging-Rolett, AM Kaiser, DW Morgens, AM Boutelle, JA Seoane, ... Molecular cell 80 (3), 452-469. e9, 2020 | 56 | 2020 |
Targeted genomic CRISPR-Cas9 screen identifies MAP4K4 as essential for glioblastoma invasion LM Prolo, A Li, SF Owen, JJ Parker, K Foshay, RT Nitta, DW Morgens, ... Scientific reports 9 (1), 14020, 2019 | 45 | 2019 |
Genome-wide interrogation of extracellular vesicle biology using barcoded miRNAs A Lu, P Wawro, DW Morgens, F Portela, MC Bassik, SR Pfeffer Elife 7, e41460, 2018 | 29 | 2018 |
Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72 N Chai, MS Haney, J Couthouis, DW Morgens, A Benjamin, K Wu, ... Brain research 1728, 146601, 2020 | 24 | 2020 |
The protein invasion: a broad review on the origin of the translational system DW Morgens Journal of molecular evolution 77, 185-196, 2013 | 24 | 2013 |