Multivalent glycoconjugates as anti-pathogenic agents A Bernardi, J Jiménez-Barbero, A Casnati, C De Castro, T Darbre, ... Chemical Society Reviews 42 (11), 4709-4727, 2013 | 581 | 2013 |
Glycosphingolipids—nature, function, and pharmacological modulation T Wennekes, RJ van den Berg, RG Boot, GA van der Marel, HS Overkleeft, ... Angewandte Chemie International Edition 48 (47), 8848-8869, 2009 | 356 | 2009 |
Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity JM Aerts, R Ottenhoff, AS Powlson, A Grefhorst, M Van Eijk, ... Diabetes 56 (5), 1341-1349, 2007 | 342 | 2007 |
Identification of the non-lysosomal glucosylceramidase as β-glucosidase 2 RG Boot, M Verhoek, W Donker-Koopman, A Strijland, J van Marle, ... Journal of Biological Chemistry 282 (2), 1305-1312, 2007 | 236 | 2007 |
Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity JH Kim, R Resende, T Wennekes, HM Chen, N Bance, S Buchini, ... Science 340 (6128), 71-75, 2013 | 217 | 2013 |
Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man T Wennekes, RJ van den Berg, W Donker, GA van der Marel, A Strijland, ... The Journal of organic chemistry 72 (4), 1088-1097, 2007 | 172 | 2007 |
Hydrolytic and thermal stability of organic monolayers on various inorganic substrates NS Bhairamadgi, SP Pujari, FG Trovela, A Debrassi, AA Khamis, ... Langmuir 30 (20), 5829-5839, 2014 | 116 | 2014 |
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation T Wennekes, AJ Meijer, AK Groen, RG Boot, JE Groener, M van Eijk, ... Journal of medicinal chemistry 53 (2), 689-698, 2010 | 114 | 2010 |
A protein‐based pentavalent inhibitor of the cholera toxin B‐subunit TR Branson, TE McAllister, J Garcia‐Hartjes, MA Fascione, JF Ross, ... Angewandte Chemie 126 (32), 8463-8467, 2014 | 98 | 2014 |
N-glycolylneuraminic acid as a receptor for influenza A viruses F Broszeit, N Tzarum, X Zhu, N Nemanichvili, D Eggink, T Leenders, Z Li, ... Cell reports 27 (11), 3284-3294. e6, 2019 | 95 | 2019 |
Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase AJ Thompson, RJ Williams, Z Hakki, DS Alonzi, T Wennekes, TM Gloster, ... Proceedings of the National Academy of Sciences 109 (3), 781-786, 2012 | 89 | 2012 |
The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation N Dekker, T Voorn-Brouwer, M Verhoek, T Wennekes, RS Narayan, ... Blood Cells, Molecules, and Diseases 46 (1), 19-26, 2011 | 72 | 2011 |
Glycosphingolipids and insulin resistance JM Aerts, RG Boot, M van Eijk, J Groener, N Bijl, E Lombardo, FM Bietrix, ... Sphingolipids and metabolic disease, 99-119, 2011 | 69 | 2011 |
A fluorescence polarization activity-based protein profiling assay in the discovery of potent, selective inhibitors for human nonlysosomal glucosylceramidase D Lahav, B Liu, RJ van den Berg, AMCH van den Nieuwendijk, ... Journal of the American Chemical Society 139 (40), 14192-14197, 2017 | 68 | 2017 |
Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors AT Ghisaidoobe, RJ van den Berg, SS Butt, A Strijland, ... Journal of medicinal chemistry 57 (21), 9096-9104, 2014 | 63 | 2014 |
Getting a grip on glycans: a current overview of the metabolic oligosaccharide engineering toolbox TJ Sminia, H Zuilhof, T Wennekes Carbohydrate research 435, 121-141, 2016 | 62 | 2016 |
Picomolar inhibition of cholera toxin by a pentavalent ganglioside GM1os-calix [5] arene J Garcia-Hartjes, S Bernardi, CAGM Weijers, T Wennekes, M Gilbert, ... Organic & biomolecular chemistry 11 (26), 4340-4349, 2013 | 61 | 2013 |
Synthesis and evaluation of dimeric lipophilic iminosugars as inhibitors of glucosylceramide metabolism T Wennekes, RJ van den Berg, KM Bonger, WE Donker-Koopman, ... Tetrahedron: Asymmetry 20 (6-8), 836-846, 2009 | 56 | 2009 |
Large-Scale Synthesis of the Glucosylceramide Synthase Inhibitor N-[5-(Adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin T Wennekes, B Lang, M Leeman, GA Marel, E Smits, M Weber, ... Organic Process Research & Development 12 (3), 414-423, 2008 | 54 | 2008 |
Mechanism-based inhibitors of glycosidases: design and applications WW Kallemeijn, MD Witte, T Wennekes, JMFG Aerts Advances in carbohydrate chemistry and biochemistry 71, 297-338, 2014 | 50 | 2014 |