| The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells WJ Harris, X Huang, JT Lynch, GJ Spencer, JR Hitchin, Y Li, F Ciceri, ... Cancer cell 21 (4), 473-487, 2012 | 643 | 2012 |
| Expression profiling and functional analysis of wnt signaling mechanisms in mesenchymal stem cells SL Etheridge, GJ Spencer, DJ Heath, PG Genever Stem cells 22 (5), 849-860, 2004 | 465 | 2004 |
| Wnt signalling in osteoblasts regulates expression of the receptor activator of NFκB ligand and inhibits osteoclastogenesis in vitro GJ Spencer, JC Utting, SL Etheridge, TR Arnett, PG Genever Journal of cell science 119 (7), 1283-1296, 2006 | 418 | 2006 |
| Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells TCP Somervaille, CJ Matheny, GJ Spencer, M Iwasaki, JL Rinn, ... Cell stem cell 4 (2), 129-140, 2009 | 396 | 2009 |
| Targeting the RNA m6A reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukemia J Paris, M Morgan, J Campos, GJ Spencer, A Shmakova, I Ivanova, ... Cell stem cell 25 (1), 137-148. e6, 2019 | 389 | 2019 |
| Enhancer activation by pharmacologic displacement of LSD1 from GFI1 induces differentiation in acute myeloid leukemia A Maiques-Diaz, GJ Spencer, JT Lynch, F Ciceri, EL Williams, ... Cell reports 22 (13), 3641-3659, 2018 | 180 | 2018 |
| Evidence for targeted vesicular glutamate exocytosis in osteoblasts PS Bhangu, PG Genever, GJ Spencer, TS Grewal, TM Skerry Bone 29 (1), 16-23, 2001 | 105 | 2001 |
| A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival JG Jude, GJ Spencer, X Huang, TDD Somerville, DR Jones, N Divecha, ... Oncogene 34 (10), 1253-1262, 2015 | 82 | 2015 |
| Frequent derepression of the mesenchymal transcription factor gene FOXC1 in acute myeloid leukemia TDD Somerville, DH Wiseman, GJ Spencer, X Huang, JT Lynch, ... Cancer cell 28 (3), 329-342, 2015 | 68 | 2015 |
| Emerging neuroskeletal signalling pathways: a review GJ Spencer, IS Hitchcock, PG Genever FEBS letters 559 (1-3), 6-12, 2004 | 59 | 2004 |
| Discovery and optimization of allosteric inhibitors of mutant isocitrate dehydrogenase 1 (R132H IDH1) displaying activity in human acute myeloid leukemia cells S Jones, J Ahmet, K Ayton, M Ball, M Cockerill, E Fairweather, N Hamilton, ... Journal of Medicinal Chemistry 59 (24), 11120-11137, 2016 | 52 | 2016 |
| Current perspectives on NMDA-type glutamate signalling in bone GJ Spencer, CJ McGrath, PG Genever The International Journal of Biochemistry & Cell Biology 39 (6), 1089-1104, 2007 | 51 | 2007 |
| Long-term potentiation in bone–a role for glutamate in strain-induced cellular memory? GJ Spencer, PG Genever BMC cell biology 4, 1-4, 2003 | 47 | 2003 |
| Development of (4-cyanophenyl) glycine derivatives as reversible inhibitors of lysine specific demethylase 1 DP Mould, C Alli, U Bremberg, S Cartic, AM Jordan, M Geitmann, ... Journal of Medicinal Chemistry 60 (19), 7984-7999, 2017 | 45 | 2017 |
| Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells X Huang, GJ Spencer, JT Lynch, F Ciceri, TDD Somerville, ... Leukemia 28 (5), 1081-1091, 2014 | 41 | 2014 |
| Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia G Deb, B Wingelhofer, FMR Amaral, A Maiques-Diaz, JA Chadwick, ... Leukemia 34 (5), 1266-1277, 2020 | 39 | 2020 |
| LSD1 inhibitors disrupt the GFI1 transcription repressor complex A Maiques-Diaz, JT Lynch, GJ Spencer, TCP Somervaille Molecular & cellular oncology 5 (4), e1481813, 2018 | 23 | 2018 |
| Derepression of the Iroquois homeodomain transcription factor gene IRX3 confers differentiation block in acute leukemia TDD Somerville, F Simeoni, JA Chadwick, EL Williams, GJ Spencer, ... Cell Reports 22 (3), 638-652, 2018 | 22 | 2018 |
| CCS1477: a novel small molecule inhibitor of p300/CBP bromodomain for the treatment of acute myeloid leukaemia and multiple myeloma N Brooks, M Raja, BW Young, GJ Spencer, TCP Somervaille, NA Pegg Blood 134, 2560, 2019 | 21 | 2019 |
| Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia F Simeoni, I Romero-Camarero, F Camera, FMR Amaral, OJ Sinclair, ... Cell Reports 36 (12), 2021 | 17 | 2021 |
