High-content CRISPR screening C Bock, P Datlinger, F Chardon, MA Coelho, MB Dong, KA Lawson, T Lu, ... Nature Reviews Methods Primers 2 (1), 1-23, 2022 | 366 | 2022 |
Systematic immunotherapy target discovery using genome-scale in vivo CRISPR screens in CD8 T cells MB Dong, G Wang, RD Chow, L Ye, L Zhu, X Dai, JJ Park, HR Kim, ... Cell 178 (5), 1189-1204. e23, 2019 | 248 | 2019 |
AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma RD Chow, CD Guzman, G Wang, F Schmidt, MW Youngblood, L Ye, ... Nature neuroscience 20 (10), 1329-1341, 2017 | 230 | 2017 |
Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNA S Yuan, L Peng, JJ Park, Y Hu, SC Devarkar, MB Dong, Q Shen, S Wu, ... Molecular cell 80 (6), 1055-1066. e6, 2020 | 168 | 2020 |
In vivo CRISPR screening in CD8 T cells with AAV–Sleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma L Ye, JJ Park, MB Dong, Q Yang, RD Chow, L Peng, Y Du, J Guo, X Dai, ... Nature biotechnology 37 (11), 1302-1313, 2019 | 153 | 2019 |
A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy L Ye, JJ Park, L Peng, Q Yang, RD Chow, MB Dong, SZ Lam, J Guo, ... Cell metabolism 34 (4), 595-614. e14, 2022 | 103 | 2022 |
Multiplexed activation of endogenous genes by CRISPRa elicits potent antitumor immunity G Wang, RD Chow, Z Bai, L Zhu, Y Errami, X Dai, MB Dong, L Ye, ... Nature Immunology 20 (11), 1494-1505, 2019 | 98 | 2019 |
CRISPR-GEMM pooled mutagenic screening identifies KMT2D as a major modulator of immune checkpoint blockade G Wang, RD Chow, L Zhu, Z Bai, L Ye, F Zhang, PA Renauer, MB Dong, ... Cancer discovery 10 (12), 1912-1933, 2020 | 96 | 2020 |
Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR–mediated direct in vivo screening G Wang, RD Chow, L Ye, CD Guzman, X Dai, MB Dong, F Zhang, ... Science advances 4 (2), eaao5508, 2018 | 92 | 2018 |
In vivo profiling of metastatic double knockouts through CRISPR–Cpf1 screens RD Chow, G Wang, L Ye, A Codina, HR Kim, L Shen, MB Dong, Y Errami, ... Nature methods 16 (5), 405-408, 2019 | 56 | 2019 |
Flow cytometric gating for spleen monocyte and DC subsets: differences in autoimmune NOD mice and with acute inflammation MB Dong, MJ Rahman, KV Tarbell Journal of immunological methods 432, 4-12, 2016 | 38 | 2016 |
Diacylglycerol kinase ζ limits B cell antigen receptor–dependent activation of ERK signaling to inhibit early antibody responses ML Wheeler, MB Dong, R Brink, XP Zhong, AL DeFranco Science signaling 6 (297), ra91-ra91, 2013 | 27 | 2013 |
Tumor immunology CRISPR screening: present, past, and future MB Dong, K Tang, X Zhou, JJ Zhou, S Chen Trends in cancer 8 (3), 210-225, 2022 | 23 | 2022 |
Convergent identification and interrogation of tumor-intrinsic factors that modulate cancer immunity in vivo A Codina, PA Renauer, G Wang, RD Chow, JJ Park, H Ye, K Zhang, ... Cell systems 8 (2), 136-151. e7, 2019 | 21 | 2019 |
Determinants of divergent adaptive immune responses after airway sensitization with ligands of toll-like receptor 5 or toll-like receptor 9 LM Lee, M Ji, M Sinha, MB Dong, X Ren, Y Wang, CA Lowell, S Ghosh, ... PLoS One 11 (12), e0167693, 2016 | 16 | 2016 |
Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B. 1.617 L Peng, Y Hu, MC Mankowski, P Ren, RE Chen, J Wei, M Zhao, T Li, ... Nature communications 13 (1), 1638, 2022 | 15 | 2022 |
Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species L Peng, Z Fang, PA Renauer, A McNamara, JJ Park, Q Lin, X Zhou, ... Cell Reports 40 (5), 2022 | 14 | 2022 |
Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2 L Peng, PA Renauer, A Ökten, Z Fang, JJ Park, X Zhou, Q Lin, MB Dong, ... Cell Reports Medicine 3 (5), 2022 | 13 | 2022 |
CTLA-4 tail fusion enhances CAR-T antitumor immunity X Zhou, H Cao, SY Fang, RD Chow, K Tang, M Majety, M Bai, MB Dong, ... Nature Immunology 24 (9), 1499-1510, 2023 | 11 | 2023 |
Despite increased type 1 IFN, autoimmune nonobese diabetic mice display impaired dendritic cell response to CpG and decreased nuclear localization of IFN-activated STAT1 MJ Rahman, G Rahir, MB Dong, Y Zhao, KB Rodrigues, C Hotta-Iwamura, ... The Journal of Immunology 196 (5), 2031-2040, 2016 | 10 | 2016 |