The blood-brain barrier in aging and neurodegeneration EG Knox, MR Aburto, G Clarke, JF Cryan, CM O’Driscoll Molecular Psychiatry 27 (6), 2659-2673, 2022 | 232 | 2022 |
Short chain fatty acids: microbial metabolites for gut-brain axis signalling KJ O'Riordan, MK Collins, GM Moloney, EG Knox, MR Aburto, C Fülling, ... Molecular and Cellular Endocrinology 546, 111572, 2022 | 184 | 2022 |
A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system JF Alterman, BMDC Godinho, MR Hassler, CM Ferguson, D Echeverria, ... Nature biotechnology 37 (8), 884-894, 2019 | 166 | 2019 |
Microbial-derived metabolites induce actin cytoskeletal rearrangement and protect blood-brain barrier function EG Knox, MR Aburto, C Tessier, J Nagpal, G Clarke, CM O’Driscoll, ... iscience 25 (12), 2022 | 28 | 2022 |
Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep CM Ferguson, BMDC Godinho, JF Alterman, AH Coles, M Hassler, ... JCI insight 6 (24), 2021 | 16 | 2021 |
Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington’s disease models F Conroy, R Miller, JF Alterman, MR Hassler, D Echeverria, ... Nature communications 13 (1), 5802, 2022 | 14 | 2022 |
PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs BMDC Godinho, EG Knox, S Hildebrand, JW Gilbert, D Echeverria, ... Molecular Therapy-Nucleic Acids 29, 116-132, 2022 | 14 | 2022 |
The gut microbiota is important for the maintenance of blood–cerebrospinal fluid barrier integrity EG Knox, CMK Lynch, YS Lee, CM O'Driscoll, G Clarke, JF Cryan, ... European Journal of Neuroscience 57 (2), 233-241, 2023 | 12 | 2023 |
2′-O-Methyl at 20-mer guide strand 3′ termini may negatively affect target silencing activity of fully chemically modified siRNA SM Davis, J Sousa, L Vangjeli, MR Hassler, D Echeverria, E Knox, ... Molecular Therapy-Nucleic Acids 21, 266-277, 2020 | 11 | 2020 |
Microbial-derived metabolites induce actin cytoskeletal rearrangement and protect blood-brain barrier function. iScience 25 EG Knox, MR Aburto, C Tessier, J Nagpal, G Clarke, CM O’Driscoll, ... | 7 | 2022 |
The role of the gut microbiota in the function and integrity of brain barriers EG Knox University College Cork, 2023 | | 2023 |
Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in vivo in CNS F Conroy, R Miller, JF Alterman, MR Hassler, D Echeverria, ... bioRxiv, 2022.06. 29.498088, 2022 | | 2022 |
The gut microbiota is important for the maintenance of blood-cerebrospinal fluid barrier integrity. YS Lee, M Rodriguez Aburto, E Knox, C Lynch, C O'Driscoll, G Clarke, ... | | 2022 |
Microbial metabolites and blood brain barrier physiology/integrity: focus on mechanisms E Knox, MR Aburto, G Clarke, JF Cryan, C O'Driscoll Neuroscience Applied 1, 100023, 2022 | | 2022 |
Chemical Engineering of Therapeutic RNAs for Allele Specific Gene Silencing In Vivo F Conroy, J Alterman, B Godinho, E Sapp, D Echeverria, M Hassler, ... MOLECULAR THERAPY 28 (4), 393-393, 2020 | | 2020 |