Development of a new permeability assay using low‐efflux MDCKII cells L Di, C Whitney‐Pickett, JP Umland, H Zhang, X Zhang, DF Gebhard, ... Journal of pharmaceutical sciences 100 (11), 4974-4985, 2011 | 280 | 2011 |
Colloidal Graphite-Assisted Laser Desorption/Ionization MS and MSn of Small Molecules. 2. Direct Profiling and MS Imaging of Small Metabolites from Fruits H Zhang, S Cha, ES Yeung Analytical chemistry 79 (17), 6575-6584, 2007 | 170 | 2007 |
pH-Dependent solubility and permeability criteria for provisional biopharmaceutics classification (BCS and BDDCS) in early drug discovery MV Varma, I Gardner, SJ Steyn, P Nkansah, CJ Rotter, C Whitney-Pickett, ... Molecular pharmaceutics 9 (5), 1199-1212, 2012 | 165 | 2012 |
Direct profiling and imaging of plant metabolites in intact tissues by using colloidal graphite‐assisted laser desorption ionization mass spectrometry S Cha, H Zhang, HI Ilarslan, ES Wurtele, L Brachova, BJ Nikolau, ... The Plant Journal 55 (2), 348-360, 2008 | 150 | 2008 |
Acoustic ejection mass spectrometry for high-throughput analysis H Zhang, C Liu, W Hua, LP Ghislain, J Liu, L Aschenbrenner, S Noell, ... Analytical Chemistry 93 (31), 10850-10861, 2021 | 82 | 2021 |
The RESOLUTE consortium: unlocking SLC transporters for drug discovery G Superti-Furga, D Lackner, T Wiedmer, A Ingles-Prieto, B Barbosa, ... Nature reviews Drug discovery 19 (7), 429-430, 2020 | 74 | 2020 |
Membrane protein quantification by peptide-based mass spectrometry approaches: studies on the organic anion-transporting polypeptide family LMBE Kimoto Journal of Proteomics & Bioinformatics 6 (10), 2013 | 70 | 2013 |
Quantitative contribution of six major transporters to the hepatic uptake of drugs:“SLC-phenotyping” using primary human hepatocytes Y Bi, C Costales, S Mathialagan, M West, S Eatemadpour, S Lazzaro, ... Journal of Pharmacology and Experimental Therapeutics 370 (1), 72-83, 2019 | 69 | 2019 |
In vitro–in vivo correlation for low-clearance compounds using hepatocyte relay method L Di, K Atkinson, CC Orozco, C Funk, H Zhang, TS McDonald, B Tan, J Lin, ... Drug Metabolism and Disposition 41 (12), 2018-2023, 2013 | 68 | 2013 |
Aldehyde oxidase 1 (AOX1) in human liver cytosols: quantitative characterization of AOX1 expression level and activity relationship C Fu, L Di, X Han, C Soderstrom, M Snyder, MD Troutman, RS Obach, ... Drug Metabolism and Disposition 41 (10), 1797-1804, 2013 | 68 | 2013 |
In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation Y Bi, E Kimoto, S Sevidal, HM Jones, HA Barton, S Kempshall, ... Drug Metabolism and Disposition 40 (6), 1085-1092, 2012 | 66 | 2012 |
Electromigration of single molecules of DNA in a crystalline array of 300-nm silica colloids H Zhang, MJ Wirth Analytical chemistry 77 (5), 1237-1242, 2005 | 57 | 2005 |
Ultra-high-throughput acoustic droplet ejection-open port interface-mass spectrometry for parallel medicinal chemistry KJ DiRico, W Hua, C Liu, JW Tucker, AS Ratnayake, ME Flanagan, ... ACS Medicinal Chemistry Letters 11 (6), 1101-1110, 2020 | 56 | 2020 |
Mobility-based wall adsorption isotherms for comparing capillary electrophoresis with single-molecule observations N Fang, H Zhang, J Li, HW Li, ES Yeung Analytical chemistry 79 (16), 6047-6054, 2007 | 53 | 2007 |
Quantitative gel electrophoresis: sources of variation S Schröder, H Zhang, ES Yeung, L Jänsch, C Zabel, H Wätzig Journal of Proteome Research 7 (3), 1226-1234, 2008 | 51 | 2008 |
Assessing physicochemical properties of drug molecules via microsolvation measurements with differential mobility spectrometry C Liu, JCY Le Blanc, BB Schneider, J Shields, JJ Federico III, H Zhang, ... ACS Central Science 3 (2), 101-109, 2017 | 50 | 2017 |
Reliable rate measurements for active and passive hepatic uptake using plated human hepatocytes Y Bi, RJ Scialis, S Lazzaro, S Mathialagan, E Kimoto, J Keefer, H Zhang, ... The AAPS journal 19, 787-796, 2017 | 43 | 2017 |
Differential modulation of cytochrome P450 activity and the effect of 1-aminobenzotriazole on hepatic transport in sandwich-cultured human hepatocytes E Kimoto, R Walsky, H Zhang, Y Bi, KM Whalen, YS Yang, C Linder, ... Drug Metabolism and Disposition 40 (2), 407-411, 2012 | 42 | 2012 |
High-throughput mass spectrometry for hit identification: current landscape and future perspectives DG McLaren, V Shah, T Wisniewski, L Ghislain, C Liu, H Zhang, ... SLAS DISCOVERY: Advancing the Science of Drug Discovery 26 (2), 168-191, 2021 | 41 | 2021 |
Linkage position and residue identification of disaccharides by tandem mass spectrometry and linear discriminant analysis H Zhang, SM Brokman, N Fang, NL Pohl, ES Yeung Rapid Communications in Mass Spectrometry: An International Journal Devoted …, 2008 | 40 | 2008 |