Structural evidence of a major conformational change triggered by substrate binding in DapE enzymes: impact on the catalytic mechanism B Nocek, C Reidl, A Starus, T Heath, D Bienvenue, J Osipiuk, ... Biochemistry 57 (5), 574-584, 2018 | 33 | 2018 |
Practical spectrophotometric assay for the dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase, a potential antibiotic target TK Heath, MR Lutz Jr, CT Reidl, ER Guzman, CA Herbert, BP Nocek, ... PloS one 13 (4), e0196010, 2018 | 30 | 2018 |
First contact: 7-phenyl-2-aminoquinolines, potent and selective neuronal nitric oxide synthase inhibitors that target an isoform-specific aspartate MA Cinelli, CT Reidl, H Li, G Chreifi, TL Poulos, RB Silverman Journal of medicinal chemistry 63 (9), 4528-4554, 2020 | 21 | 2020 |
Indoline-6-sulfonamide inhibitors of the bacterial enzyme DapE CT Reidl, TK Heath, I Darwish, RM Torrez, M Moore, E Gild, BP Nocek, ... Antibiotics 9 (9), 595, 2020 | 15 | 2020 |
Synthesis of a protected 2-aminocyclobutanone as a modular transition state synthon for medicinal chemistry TSH Mohammad, CT Reidl, M Zeller, DP Becker Tetrahedron Letters 61 (12), 151632, 2020 | 11 | 2020 |
Generating enzyme and radical‐mediated bisubstrates as tools for investigating Gcn5‐related N‐acetyltransferases C Reidl, KA Majorek, J Dang, D Tran, K Jew, M Law, Y Payne, W Minor, ... FEBS letters 591 (15), 2348-2361, 2017 | 8 | 2017 |
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis MF Elmansy, CT Reidl, M Rahaman, PH Özdinler, RB Silverman Medicinal Research Reviews 43 (6), 2260-2302, 2023 | 5 | 2023 |
Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase H Li, CD Hardy, CT Reidl, Q Jing, F Xue, M Cinelli, RB Silverman, ... Biochemistry 63 (6), 788-796, 2024 | 3 | 2024 |
In Silico Binding of 2-Aminocyclobutanones to SARS-CoV-2 Nsp13 Helicase and Demonstration of Antiviral Activity TSH Mohammad, Y Gupta, CT Reidl, V Nicolaescu, H Gula, R Durvasula, ... International journal of molecular sciences 24 (6), 5120, 2023 | 3 | 2023 |
Cyclobutanone inhibitor of cobalt-functionalized metallo-γ-lactonase AiiA with cyclobutanone ring opening in the active site CT Reidl, R Mascarenhas, TSH Mohammad, MR Lutz Jr, PW Thomas, ... ACS omega 6 (21), 13567-13578, 2021 | 3 | 2021 |
(S)‐4‐Amino‐5‐phenoxypentanoate designed as a potential selective agonist of the bacterial transcription factor GabR DS Catlin, CT Reidl, TR Trzupek, RB Silverman, BL Cannon, DP Becker, ... Protein Science 29 (8), 1816-1828, 2020 | 3 | 2020 |
Cyclobutanone Inhibitors of Diaminopimelate Desuccinylase (DapE) as Potential New Antibiotics TS Habeeb Mohammad, EH Kelley, CT Reidl, K Konczak, M Beulke, ... International Journal of Molecular Sciences 25 (2), 1339, 2024 | 2 | 2024 |
PA4794 Gcn5‐related N‐acetyltransferase bisubstrate inhibitors and mechanistic insights from co‐crystal structures, site‐directed mutants, and molecular dynamics CT Reidl, KA Majorek, J Dang, M Law, D Tran, K Jew, P Chiarelli, W Minor, ... The FASEB Journal 31, 923.6-923.6, 2017 | 2 | 2017 |
Mapping roles of active site residues in the acceptor site of the PA3944 Gcn5‐related N‐acetyltransferase enzyme C Variot, D Capule, X Arolli, J Baumgartner, C Reidl, C Houseman, ... Protein Science 32 (8), e4725, 2023 | 1 | 2023 |
Improved synthesis and anticancer activity of a potent neuronal nitric oxide synthase inhibitor D Vasu, CT Reidl, E Wang, S Yang, RB Silverman Bioorganic & medicinal chemistry letters 90, 129329, 2023 | 1 | 2023 |
Indoline sulfonamide inhibitors of DapE and NDM-1 and use of the same DP Becker, TK Heath, C Reidl, W Fast US Patent 11,021,469, 2021 | 1 | 2021 |
Indoline and tetrahydroquinoline sulfonyl inhibitors of dimetalloenzymes and use of the same DP Becker, C Reidl, M Moore, TK Heath, W Fast US Patent 10,626,087, 2020 | 1 | 2020 |
Bioisosteric replacement of pyridoxal‐5′‐phosphate to pyridoxal‐5′‐tetrazole targeting Bacillus subtilis GabR NE Kaley, ZJ Liveris, M Moore, CT Reidl, Z Wawrzak, DP Becker, D Liu Protein Science 34 (1), e70014, 2025 | | 2025 |
Selective neuronal nitric oxide synthase inhibitors RB Silverman, MA Cinelli, CT Reidl US Patent App. 17/770,352, 2022 | | 2022 |
(S);# 8208; 4;# 8208; Amino;# 8208; 5;# 8208; phenoxypentanoate designed as a potential selective agonist of the bacterial transcription factor GabR DS Catlin, CT Reidl, TR Trzupek, RB Silverman, BL Cannon, DP Becker, ... Protein Sci. 29 (8); 08, 2020), 2020 | | 2020 |