DAP‐kinase‐mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl‐XL and induction of autophagy E Zalckvar, H Berissi, L Mizrachy, Y Idelchuk, I Koren, M Eisenstein, ... EMBO reports 10 (3), 285-292, 2009 | 722 | 2009 |
Quantitative proteomic atlas of ubiquitination and acetylation in the DNA damage response AEH Elia, AP Boardman, DC Wang, EL Huttlin, RA Everley, N Dephoure, ... Molecular cell 59 (5), 867-881, 2015 | 367 | 2015 |
The eukaryotic proteome is shaped by E3 ubiquitin ligases targeting C-terminal degrons I Koren, RT Timms, T Kula, Q Xu, MZ Li, SJ Elledge Cell 173 (7), 1622-1635. e14, 2018 | 231 | 2018 |
DAP1, a novel substrate of mTOR, negatively regulates autophagy I Koren, E Reem, A Kimchi Current biology 20 (12), 1093-1098, 2010 | 196 | 2010 |
A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation RT Timms, Z Zhang, DY Rhee, JW Harper, I Koren, SJ Elledge Science 365 (6448), eaaw4912, 2019 | 149 | 2019 |
Tying up loose ends: the N-degron and C-degron pathways of protein degradation RT Timms, I Koren Biochemical Society Transactions 48 (4), 1557-1567, 2020 | 65 | 2020 |
Promoting tumorigenesis by suppressing autophagy I Koren, A Kimchi Science 338 (6109), 889-890, 2012 | 52 | 2012 |
Autophagy gets a brake: DAP1, a novel mTOR substrate, is activated to suppress the autophagic process I Koren, E Reem, A Kimchi Autophagy 6 (8), 1179-1180, 2010 | 48 | 2010 |
Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase X Chen, S Liao, Y Makaros, Q Guo, Z Zhu, R Krizelman, K Dahan, X Tu, ... Nature Chemical Biology 17 (3), 254-262, 2021 | 34 | 2021 |
Ubiquitin-independent proteasomal degradation driven by C-degron pathways Y Makaros, A Raiff, RT Timms, AR Wagh, MI Gueta, A Bekturova, ... Molecular Cell 83 (11), 1921-1935. e7, 2023 | 20 | 2023 |
A model-driven methodology for exploring complex disease comorbidities applied to autism spectrum disorder and inflammatory bowel disease J Somekh, M Peleg, A Eran, I Koren, A Feiglin, A Demishtein, R Shiloh, ... Journal of biomedical informatics 63, 366-378, 2016 | 16 | 2016 |
Defining E3 ligase–substrate relationships through multiplex CRISPR screening RT Timms, EL Mena, Y Leng, MZ Li, IA Tchasovnikarova, I Koren, ... Nature cell biology 25 (10), 1535-1545, 2023 | 11 | 2023 |
Molecular basis for C-degron recognition by CRL2APPBP2 ubiquitin ligase S Zhao, D Olmayev-Yaakobov, W Ru, S Li, X Chen, J Zhang, X Yao, ... Proceedings of the National Academy of Sciences 120 (43), e2308870120, 2023 | 1 | 2023 |
Dipeptidyl peptidases and E3 ligases of N-degron pathways cooperate to regulate protein stability A Shimshon, K Dahan, M Israel-Gueta, D Olmayev-Yaakobov, RT Timms, ... Journal of Cell Biology 223 (8), 2024 | | 2024 |
Mechanism of Ψ-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase X Chen, A Raiff, S Li, Q Guo, J Zhang, H Zhou, RT Timms, X Yao, ... Nature Communications 15 (1), 3558, 2024 | | 2024 |
Author Correction: Defining E3 ligase–substrate relationships through multiplex CRISPR screening RT Timms, EL Mena, Y Leng, MZ Li, IA Tchasovnikarova, I Koren, ... nature cell biology 26 (2), 305-305, 2024 | | 2024 |
Meet the author: Itay Koren I Koren Molecular Cell 83 (11), 1761-1762, 2023 | | 2023 |
The hidden (degron) truth behind the degradation of DHFR disease-associated variants I Koren Structure 30 (9), 1219-1221, 2022 | | 2022 |