| Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis T Uehara, GR Ainslie, K Kutanzi, IP Pogribny, L Muskhelishvili, T Izawa, ... Toxicological sciences 132 (1), 53-63, 2013 | 121 | 2013 |
| Succinic semialdehyde dehydrogenase deficiency (SSADHD): Pathophysiological complexity and multifactorial trait associations in a rare monogenic disorder of GABA metabolism P Malaspina, JB Roullet, PL Pearl, GR Ainslie, KR Vogel, KM Gibson Neurochemistry international 99, 72-84, 2016 | 81 | 2016 |
| Mechanistic basis of altered morphine disposition in nonalcoholic steatohepatitis AL Dzierlenga, JD Clarke, TL Hargraves, GR Ainslie, TW Vanderah, ... Journal of Pharmacology and Experimental Therapeutics 352 (3), 462-470, 2015 | 57 | 2015 |
| Succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism: an update on pharmacological and enzyme-replacement therapeutic strategies KR Vogel, GR Ainslie, DC Walters, A McConnell, SC Dhamne, ... Journal of inherited metabolic disease 41, 699-708, 2018 | 47 | 2018 |
| mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcription in murine succinate semialdehyde dehydrogenase deficiency … KR Vogel, GR Ainslie, KM Gibson Journal of inherited metabolic disease 39, 877-886, 2016 | 29 | 2016 |
| Torin 1 partially corrects vigabatrin‐induced mitochondrial increase in mouse KR Vogel, GR Ainslie, EEW Jansen, GS Salomons, KM Gibson Annals of clinical and translational neurology 2 (6), 699-706, 2015 | 27 | 2015 |
| Assessment of a candidate marker constituent predictive of a dietary substance–drug interaction: case study with grapefruit juice and CYP3A4 drug substrates GR Ainslie, KK Wolf, Y Li, EA Connolly, YV Scarlett, JH Hull, MF Paine Journal of Pharmacology and Experimental Therapeutics 351 (3), 576-584, 2014 | 26 | 2014 |
| mTOR inhibition mitigates molecular and biochemical alterations of vigabatrin-induced visual field toxicity in mice KR Vogel, GR Ainslie, MA Schmidt, JP Wisor, KM Gibson Pediatric neurology 66, 44-52. e1, 2017 | 21 | 2017 |
| Metabolomic analyses of vigabatrin (VGB)-treated mice: GABA-transaminase inhibition significantly alters amino acid profiles in murine neural and non-neural tissues DC Walters, E Arning, T Bottiglieri, EEW Jansen, GS Salomons, ... Neurochemistry international 125, 151-162, 2019 | 19 | 2019 |
| Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use‐limiting visual field defects DC Walters, EEW Jansen, GR Ainslie, GS Salomons, MN Brown, ... Pharmacology Research & Perspectives 7 (1), e00456, 2019 | 18 | 2019 |
| Gamma-hydroxybutyrate (GHB) content in hair samples correlates negatively with age in succinic semialdehyde dehydrogenase deficiency SS Johansen, X Wang, D Sejer Pedersen, PL Pearl, JB Roullet, ... JIMD Reports, Volume 36, 93-98, 2017 | 15 | 2017 |
| Therapeutic relevance of mTOR inhibition in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism KR Vogel, GR Ainslie, EEW Jansen, GS Salomons, KM Gibson Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1863 (1), 33-42, 2017 | 14 | 2017 |
| Toxicologic/transport properties of NCS-382, a γ-hydroxybutyrate (GHB) receptor ligand, in neuronal and epithelial cells: Therapeutic implications for SSADH deficiency, a GABA … KR Vogel, GR Ainslie, A McConnell, JB Roullet, KM Gibson Toxicology in Vitro 46, 203-212, 2018 | 13 | 2018 |
| Compartmental and enzyme kinetic modeling to elucidate the biotransformation pathway of a centrally acting antitrypanosomal prodrug CN Generaux, GR Ainslie, AS Bridges, MA Ismail, DW Boykin, RR Tidwell, ... Drug Metabolism and Disposition 41 (2), 518-528, 2013 | 13 | 2013 |
| Comparison of a new intranasal naloxone formulation to intramuscular naloxone: results from hypothesis‐generating small clinical studies BT Gufford, GR Ainslie, JR White Jr, ME Layton, JM Padowski, GM Pollack, ... Clinical and Translational Science 10 (5), 380-386, 2017 | 12 | 2017 |
| Aberrant mTOR signaling and disrupted autophagy: the missing link in potential vigabatrin‐associated ocular toxicity? KR Vogel, GR Ainslie, PL Pearl, KM Gibson Clinical Pharmacology & Therapeutics 101 (4), 458-461, 2017 | 11 | 2017 |
| A pharmacokinetic evaluation and metabolite identification of the GHB receptor antagonist NCS‐382 in mouse informs novel therapeutic strategies for the treatment of GHB … GR Ainslie, KM Gibson, KR Vogel Pharmacology research & perspectives 4 (6), e00265, 2016 | 11 | 2016 |
| Labeled content of two furanocoumarins in dietary supplements correlates with neither actual content nor CYP3A inhibitory activity KM VanderMolen, GR Ainslie, MF Paine, NH Oberlies Journal of pharmaceutical and biomedical analysis 98, 260-265, 2014 | 10 | 2014 |
| The effect of oligomeric environment on the kinetics of lactate dehydrogenase subunits GR Ainslie Jr, WW Cleland Archives of biochemistry and biophysics 216 (1), 101-104, 1982 | 8 | 1982 |
| In vitro modeling of experimental succinic semialdehyde dehydrogenase deficiency (SSADHD) using brain-derived neural stem cells KR Vogel, GR Ainslie, EE Jansen, GS Salomons, JB Roullet, KM Gibson PloS one 12 (10), e0186919, 2017 | 7 | 2017 |
