The nature of systems biology FJ Bruggeman, HV Westerhoff TRENDS in Microbiology 15 (1), 45-50, 2007 | 725 | 2007 |
Cancer: a systems biology disease JJ Hornberg, FJ Bruggeman, HV Westerhoff, J Lankelma Biosystems 83 (2-3), 81-90, 2006 | 530 | 2006 |
Untangling the wires: a strategy to trace functional interactions in signaling and gene networks BN Kholodenko, A Kiyatkin, FJ Bruggeman, E Sontag, HV Westerhoff, ... Proceedings of the National Academy of Sciences 99 (20), 12841-12846, 2002 | 499 | 2002 |
Lost in transition: start-up of glycolysis yields subpopulations of nongrowing cells JH Van Heerden, MT Wortel, FJ Bruggeman, JJ Heijnen, YJM Bollen, ... Science 343 (6174), 1245114, 2014 | 314 | 2014 |
Systems biology: philosophical foundations F Boogerd, FJ Bruggeman, JHS Hofmeyr, HV Westerhoff Elsevier, 2007 | 278 | 2007 |
Control of MAPK signalling: from complexity to what really matters JJ Hornberg, B Binder, FJ Bruggeman, B Schoeberl, R Heinrich, ... Oncogene 24 (36), 5533-5542, 2005 | 251 | 2005 |
Principles behind the multifarious control of signal transduction: ERK phosphorylation and kinase/phosphatase control JJ Hornberg, FJ Bruggeman, B Binder, CR Geest, AJMB De Vaate, ... The FEBS journal 272 (1), 244-258, 2005 | 242 | 2005 |
Emergence and its place in nature: A case study of biochemical networks FC Boogerd, FJ Bruggeman, RC Richardson, A Stephan, HV Westerhoff Synthese 145, 131-164, 2005 | 234 | 2005 |
How fast‐growing bacteria robustly tune their ribosome concentration to approximate growth‐rate maximization E Bosdriesz, D Molenaar, B Teusink, FJ Bruggeman The FEBS journal 282 (10), 2029-2044, 2015 | 231 | 2015 |
Community flux balance analysis for microbial consortia at balanced growth RA Khandelwal, BG Olivier, WFM Röling, B Teusink, FJ Bruggeman PloS one 8 (5), e64567, 2013 | 231 | 2013 |
Effects of sequestration on signal transduction cascades N Blüthgen, FJ Bruggeman, S Legewie, H Herzel, HV Westerhoff, ... The FEBS journal 273 (5), 895-906, 2006 | 180 | 2006 |
Calcium sensing receptor signalling in physiology and cancer SC Brennan, U Thiem, S Roth, A Aggarwal, IS Fetahu, S Tennakoon, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1833 (7), 1732-1744, 2013 | 171 | 2013 |
Towards building the silicon cell: a modular approach JL Snoep, F Bruggeman, BG Olivier, HV Westerhoff Biosystems 83 (2-3), 207-216, 2006 | 168 | 2006 |
Modular response analysis of cellular regulatory networks FJ Bruggeman, HV Westerhoff, JB Hoek, BN Kholodenko Journal of theoretical biology 218 (4), 507-520, 2002 | 165 | 2002 |
Elongation dynamics shape bursty transcription and translation M Dobrzyński, FJ Bruggeman Proceedings of the National Academy of Sciences 106 (8), 2583-2588, 2009 | 144 | 2009 |
The volumes and transcript counts of single cells reveal concentration homeostasis and capture biological noise H Kempe, A Schwabe, F Crémazy, PJ Verschure, FJ Bruggeman Molecular biology of the cell 26 (4), 797-804, 2015 | 140 | 2015 |
Constraint-based stoichiometric modelling from single organisms to microbial communities W Gottstein, BG Olivier, FJ Bruggeman, B Teusink Journal of the Royal Society Interface 13 (124), 20160627, 2016 | 106 | 2016 |
Systems biology towards life in silico: mathematics of the control of living cells HV Westerhoff, A Kolodkin, R Conradie, SJ Wilkinson, FJ Bruggeman, ... Journal of mathematical biology 58, 7-34, 2009 | 106 | 2009 |
Systems biology: the elements and principles of life HV Westerhoff, C Winder, H Messiha, E Simeonidis, M Adamczyk, ... FEBS letters 583 (24), 3882-3890, 2009 | 105 | 2009 |
Taking chances and making mistakes: non-genetic phenotypic heterogeneity and its consequences for surviving in dynamic environments C van Boxtel, JH van Heerden, N Nordholt, P Schmidt, FJ Bruggeman Journal of The Royal Society Interface 14 (132), 20170141, 2017 | 103 | 2017 |