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Ryan Gonciarz
Ryan Gonciarz
Exelixis
在 exelixis.com 的电子邮件经过验证
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Ferrous iron-dependent pharmacology
RL Gonciarz, EA Collisson, AR Renslo
Trends in pharmacological sciences 42 (1), 7-18, 2021
342021
Emerging role of ferrous iron in bacterial growth and host–pathogen interaction: New tools for chemical (micro) biology and antibacterial therapy
RL Gonciarz, AR Renslo
Current opinion in chemical biology 61, 170-178, 2021
242021
Selective ablation of primary and paracrine senescent cells by targeting iron dyshomeostasis
TD Admasu, K Kim, M Rae, R Avelar, RL Gonciarz, A Rebbaa, ...
Cell Reports 42 (2), 2023
222023
Antimalarial trioxolanes with superior drug-like properties and in vivo efficacy
BR Blank, RL Gonciarz, P Talukder, J Gut, J Legac, PJ Rosenthal, ...
ACS infectious diseases 6 (7), 1827-1835, 2020
222020
Ferrous iron–activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors
H Jiang, RK Muir, RL Gonciarz, AB Olshen, I Yeh, BC Hann, N Zhao, ...
Journal of Experimental Medicine 219 (4), e20210739, 2022
212022
In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin
RL Gonciarz, H Jiang, L Tram, CL Hugelshofer, O Ekpenyong, I Knemeyer, ...
Cell Chemical Biology 30 (11), 1468-1477. e6, 2023
52023
A tandem activity-based sensing and labeling strategy reveals antioxidant response element regulation of labile iron pools
AT Pezacki, RL Gonciarz, T Okamura, CD Matier, L Torrente, K Cheng, ...
Proceedings of the National Academy of Sciences 121 (28), e2401579121, 2024
32024
Elevated labile iron in castration–resistant prostate cancer is targetable with ferrous iron–activatable antiandrogen therapy
RL Gonciarz, S Sakhamuri, N Hooshdaran, G Kumar, H Kim, MJ Evans, ...
European journal of medicinal chemistry 249, 115110, 2023
32023
Expanded scope of Griesbaum co-ozonolysis for the preparation of structurally diverse sensors of ferrous iron
J Chen, RL Gonciarz, AR Renslo
RSC advances 11 (54), 34338-34342, 2021
32021
The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2
RK Suryawanshi, P Jaishankar, GJ Correy, MM Rachman, PC O’Leary, ...
bioRxiv, 2024
22024
Exploiting KRAS-driven ferroaddiction in cancer through ferrous iron-activatable drug conjugates (FeADC)
H Jiang, RK Muir, RL Gonciarz, AB Olshen, I Yeh, BC Hann, N Zhao, ...
bioRxiv, 2020.05. 12.088971, 2020
22020
Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance
MT Klope, P Talukder, BR Blank, S Chelebieva, J Chen, SD Fontaine, ...
bioRxiv, 2025.01. 02.631109, 2025
2025
Synthesis and In Vivo Profiling of Desymmetrized Antimalarial Trioxolanes with Diverse Carbamate Side Chains
MT Klope, JA Tapia Cardona, J Chen, RL Gonciarz, K Cheng, ...
ACS Medicinal Chemistry Letters 15 (10), 1764-1770, 2024
2024
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