| Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus MJ Sofia, D Bao, W Chang, J Du, D Nagarathnam, S Rachakonda, ... Journal of medicinal chemistry 53 (19), 7202-7218, 2010 | 760 | 2010 |
| An orally available non-nucleotide STING agonist with antitumor activity BS Pan, SA Perera, JA Piesvaux, JP Presland, GK Schroeder, ... Science 369 (6506), eaba6098, 2020 | 381 | 2020 |
| Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase MJ Sofia, W Chang, PA Furman, RT Mosley, BS Ross Journal of medicinal chemistry 55 (6), 2481-2531, 2012 | 356 | 2012 |
| Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977 E Murakami, T Tolstykh, H Bao, C Niu, HMM Steuer, D Bao, W Chang, ... Journal of biological chemistry 285 (45), 34337-34347, 2010 | 347 | 2010 |
| Synthesis of purine nucleosides BK Chun, J Du, S Rachakonda, B Ross, MJ Sofia, GR Pamulapati, ... US Patent 8,716,263, 2014 | 106 | 2014 |
| Nucleoside analogs D Bao, W Chang, D Nagarathnam, MJ Sofia US Patent 8,551,973, 2013 | 106 | 2013 |
| Effect of artemisinins and other endoperoxides on nitric oxide-related signaling pathway in RAW 264.7 mouse macrophage cells VB Konkimalla, M Blunder, B Korn, SA Soomro, H Jansen, W Chang, ... Nitric Oxide 19 (2), 184-191, 2008 | 100 | 2008 |
| Purine nucleoside phosphoramidate W Chang, D Naduthambi, D Nagarathnam, GR Pamulapati, BS Ross, ... US Patent 8,563,530, 2013 | 91 | 2013 |
| Malaria-infected mice are cured by a single dose of novel artemisinin derivatives GH Posner, IH Paik, W Chang, K Borstnik, S Sinishtaj, AS Rosenthal, ... Journal of medicinal chemistry 50 (10), 2516-2519, 2007 | 91 | 2007 |
| Discovery of PSI-353661, a novel purine nucleotide prodrug for the treatment of HCV infection W Chang, D Bao, BK Chun, D Naduthambi, D Nagarathnam, ... ACS medicinal chemistry letters 2 (2), 130-135, 2011 | 87 | 2011 |
| 2′-Deoxy-2′-α-fluoro-2′-β-C-methyl 3′, 5′-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: Discovery of PSI-352938 PG Reddy, D Bao, W Chang, BK Chun, J Du, D Nagarathnam, ... Bioorganic & Medicinal Chemistry Letters 20 (24), 7376-7380, 2010 | 79 | 2010 |
| Malaria-infected mice are cured by oral administration of new artemisinin derivatives GH Posner, W Chang, L Hess, L Woodard, S Sinishtaj, AR Usera, W Maio, ... Journal of medicinal chemistry 51 (4), 1035-1042, 2008 | 74 | 2008 |
| Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines AA Alagbala, AJ McRiner, K Borstnik, T Labonte, W Chang, JG D'Angelo, ... Journal of medicinal chemistry 49 (26), 7836-7842, 2006 | 72 | 2006 |
| Regioselectivity of Rhodium Nitrene Insertion. Syntheses of Protected Glycals of l-Daunosamine, d-Saccharosamine, and l-Ristosamine KA Parker, W Chang Organic Letters 7 (9), 1785-1788, 2005 | 72 | 2005 |
| A kinase-cGAS cascade to synthesize a therapeutic STING activator JA McIntosh, Z Liu, BM Andresen, NS Marzijarani, JC Moore, NM Marshall, ... Nature 603 (7901), 439-444, 2022 | 71 | 2022 |
| A Synthesis of l-Vancosamine Derivatives from Non-Carbohydrate Precursors by a Short Sequence Based on the Marshall, McDonald, and Du Bois Reactions KA Parker, W Chang Organic Letters 5 (21), 3891-3893, 2003 | 70 | 2003 |
| Cyclic di-nucleotide compounds as sting agonists MD Altman, BM Andresen, W Chang, ML Childers, JN Cumming, ... US Patent 20170044206 A1, 2017 | 69 | 2017 |
| From screening to targeted degradation: strategies for the discovery and optimization of small molecule ligands for PCSK9 WL Petrilli, GC Adam, RS Erdmann, P Abeywickrema, V Agnani, X Ai, ... Cell chemical biology 27 (1), 32-40. e3, 2020 | 65 | 2020 |
| Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics W Chang, RT Mosley, S Bansal, M Keilman, AM Lam, PA Furman, MJ Otto, ... Bioorganic & medicinal chemistry letters 22 (8), 2938-2942, 2012 | 65 | 2012 |
| Discovery of MK-1454: a potent cyclic dinucleotide stimulator of interferon genes agonist for the treatment of cancer W Chang, MD Altman, CA Lesburg, SA Perera, JA Piesvaux, ... Journal of Medicinal Chemistry 65 (7), 5675-5689, 2022 | 63 | 2022 |
