APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints Z Yin, N Rosenzweig, KL Kleemann, X Zhang, W Brandão, MA Margeta, ... Nature immunology 24 (11), 1839-1853, 2023 | 80 | 2023 |
Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease Z Yin, S Herron, S Silveira, K Kleemann, C Gauthier, D Mallah, Y Cheng, ... Nature neuroscience 26 (7), 1196-1207, 2023 | 57 | 2023 |
Disease-associated astrocyte epigenetic memory promotes CNS pathology HG Lee, JM Rone, Z Li, CF Akl, SW Shin, JH Lee, LE Flausino, F Pernin, ... Nature 627 (8005), 865-872, 2024 | 26 | 2024 |
Interrelations of Alzheimer´ s disease candidate biomarkers neurogranin, fatty acid‐binding protein 3 and ferritin to neurodegeneration and neuroinflammation F Brosseron, K Kleemann, CC Kolbe, F Santarelli, S Castro‐Gomez, ... Journal of neurochemistry 157 (6), 2210-2224, 2021 | 21 | 2021 |
Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease N Rosenzweig, KL Kleemann, T Rust, M Carpenter, M Grucci, M Aronchik, ... Nature Medicine 30 (10), 2990-3003, 2024 | 9 | 2024 |
Radial glia promote microglial development through integrin αVβ8-TGFβ1 signaling GL McKinsey, N Santander, X Zhang, K Kleemann, L Tran, A Katewa, ... BioRxiv, 2023 | 3 | 2023 |
Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy W Brandao, N Jain, Z Yin, KL Kleemann, M Carpenter, X Bao, JR Serrano, ... Science Translational Medicine 17 (781), eadk3690, 2025 | | 2025 |
Neuroinflammation in Alzheimer disease Nature Reviews Immunology, 2024 | | 2024 |
Exploring how APOE ε4 increases Alzheimer’s disease risk in women GAS Inglis Nature Aging 4 (8), 1032-1032, 2024 | | 2024 |
APOE4 puts breaks on neutrophil-microglia crosstalk to accelerate Alzheimer’s disease N Rosenzweig, KL Kleemann, M Grucci, M Aronchik, O Butovsky Alzheimer's Association International Conference, 2024 | | 2024 |
APOE‐4 dependent dysfunctional neutrophil‐microglia crosstalk accelerates Alzheimer’s disease N Rosenzweig, K Kleemann, M Grucci, M Aronchik, O Butovsky Alzheimer's & Dementia 19, e075072, 2023 | | 2023 |
Deletion of miR‐155 in microglia enhances their response to neurodegeneration and mitigates cognitive impairment in a mouse model of Alzheimer’s disease Z Yin, S Herron, S Silveira, K Kleemann, C Gauthier, D Mallah, C Cheng, ... Alzheimer's & Dementia 19, e076703, 2023 | | 2023 |
APOE4 impairs Microglia‐Astrocyte Crosstalk in Alzheimer Disease K Kleemann, N Rosenzweig, Z Yin, X Zhang, WN Brandao, M Margeta, ... Alzheimer's & Dementia 19, e071852, 2023 | | 2023 |
APOE4 impairs microglia‐astrocyte response in Alzheimer’s disease by inducing TGFβ‐mediated checkpoints O Butovsky, Z Yin, N Rosenzweig, K Kleemann, X Zhang, WN Brandao, ... Alzheimer's & Dementia 19, e076510, 2023 | | 2023 |
Xenon gas (Xe) treatment to restore microglial functions in Alzheimer’s disease (AD) WN Brandao, Z Yin, K Kleemann, X Zhang, N Rosenzweig, N Jain, ... Alzheimer's & Dementia 19, e076467, 2023 | | 2023 |
Suppressing ApoE ε4 allele protects against signs of Alzheimer’s disease Z Yin, N Rosenzweig, KL Kleemann, X Zhang, W Brandão, MA Margeta, ... | | 2023 |
Radial glia control microglial differentiation via integrin avb8-dependent trans-activation of TGFB1 GL McKinsey, N Santander, X Zhang, K Kleemann, A Katewa, L Tran, ... | | 2023 |