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Markus Lakemeyer
Markus Lakemeyer
Junior Group Leader, IOMC, Friedrich-Schiller University Jena
在 uni-jena.de 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
Thinking Outside the Box—Novel Antibacterials To Tackle the Resistance Crisis
M Lakemeyer, W Zhao, FA Mandl, P Hammann, SA Sieber
Angewandte Chemie International Edition 57 (44), 14440-14475, 2018
1592018
Phenyl esters are potent inhibitors of caseinolytic protease P and reveal a stereogenic switch for deoligomerization
MW Hackl, M Lakemeyer, M Dahmen, M Glaser, A Pahl, K Lorenz-Baath, ...
Journal of the American Chemical Society 137 (26), 8475-8483, 2015
1082015
Activity-based protein profiling in bacteria: Applications for identification of therapeutic targets and characterization of microbial communities
LJ Keller, BM Babin, M Lakemeyer, M Bogyo
Current Opinion in Chemical Biology 54, 45-53, 2020
522020
Reversible inhibitors arrest ClpP in a defined conformational state that can be revoked by ClpX association
A Pahl, M Lakemeyer, MT Vielberg, MW Hackl, J Vomacka, VS Korotkov, ...
Angewandte Chemie International Edition 54 (52), 15892-15896, 2015
502015
Design and synthesis of tailored human caseinolytic protease P inhibitors
TF Gronauer, MM Mandl, M Lakemeyer, MW Hackl, M Meßner, ...
Chemical Communications 54 (70), 9833-9836, 2018
322018
Quantitative map of β-lactone-induced virulence regulation
J Krysiak, M Stahl, J Vomacka, C Fetzer, M Lakemeyer, A Fux, SA Sieber
Journal of proteome research 16 (3), 1180-1192, 2017
292017
Tailored Peptide Phenyl Esters Block ClpXP Proteolysis by an Unusual Breakdown into a Heptamer–Hexamer Assembly
M Lakemeyer, E Bertosin, F Möller, D Balogh, R Strasser, H Dietz, ...
Angewandte Chemie International Edition 58 (21), 7127-7132, 2019
182019
Über bisherige Denkweisen hinaus–neue Wirkstoffe zur Überwindung der Antibiotika‐Krise
M Lakemeyer, W Zhao, FA Mandl, P Hammann, SA Sieber
Angewandte Chemie 130 (44), 14642-14682, 2018
152018
Reversible Inhibitoren arretieren ClpP in einer definierten Konformation, die durch Bindung von ClpX aufgehoben wird
A Pahl, M Lakemeyer, MT Vielberg, MW Hackl, J Vomacka, VS Korotkov, ...
Angewandte Chemie 127 (52), 16121-16126, 2015
132015
Chemoproteomic identification of a DPP4 homolog in Bacteroides thetaiotaomicron
LJ Keller, TH Nguyen, LJ Liu, BM Hurysz, M Lakemeyer, M Guerra, ...
Nature Chemical Biology, 1-11, 2023
62023
Antibiotic Acyldepsipeptides Stimulate the Streptomyces Clp-ATPase/ClpP Complex for Accelerated Proteolysis
L Reinhardt, D Thomy, M Lakemeyer, LM Westermann, J Ortega, ...
Mbio 13 (6), e01413-22, 2022
52022
Toxoplasma gondii serine hydrolases regulate parasite lipid mobilization during growth and replication within the host
O Onguka, BM Babin, M Lakemeyer, IT Foe, N Amara, SM Terrell, ...
Cell Chemical Biology 28 (10), 1501-1513. e5, 2021
52021
Structure of Staphylococcus aureus ClpP Bound to the Covalent Active Site Inhibitor Cystargolide A
A Illigmann, MT Vielberg, M Lakemeyer, F Wolf, T Dema, P Stange, ...
Angewandte Chemie (International ed. in English), e202314028, 2023
32023
Uncovering an overlooked consequence of phosphorylation: change in cysteine reactivity
M Lakemeyer, M Bogyo
Nature Methods 19 (3), 281-283, 2022
32022
Integration of bioinformatic and chemoproteomic tools for the study of enzyme conservation in closely related bacterial species
LJ Keller, M Lakemeyer, M Bogyo
Methods in enzymology 664, 1-22, 2022
32022
Chemoproteomic identification of a dipeptidyl peptidase 4 (DPP4) homolog in Bacteroides thetaiotaomicron important for envelope integrity and fitness
LJ Keller, TH Nguyen, L Liu, M Lakemeyer, DJ Gelsinger, R Chanin, ...
bioRxiv, 2022.07. 25.501481, 2022
12022
Blockade der ClpXP‐vermittelten Proteolyse mit maßgeschneiderten Peptid‐Phenylestern durch den ungewöhnlichen Zerfall in eine Heptamer‐Hexamer‐Anordnung
M Lakemeyer, E Bertosin, F Möller, D Balogh, R Strasser, H Dietz, ...
Angewandte Chemie 131 (21), 7201-7206, 2019
2019
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