Thinking Outside the Box—Novel Antibacterials To Tackle the Resistance Crisis M Lakemeyer, W Zhao, FA Mandl, P Hammann, SA Sieber Angewandte Chemie International Edition 57 (44), 14440-14475, 2018 | 159 | 2018 |
Phenyl esters are potent inhibitors of caseinolytic protease P and reveal a stereogenic switch for deoligomerization MW Hackl, M Lakemeyer, M Dahmen, M Glaser, A Pahl, K Lorenz-Baath, ... Journal of the American Chemical Society 137 (26), 8475-8483, 2015 | 108 | 2015 |
Activity-based protein profiling in bacteria: Applications for identification of therapeutic targets and characterization of microbial communities LJ Keller, BM Babin, M Lakemeyer, M Bogyo Current Opinion in Chemical Biology 54, 45-53, 2020 | 52 | 2020 |
Reversible inhibitors arrest ClpP in a defined conformational state that can be revoked by ClpX association A Pahl, M Lakemeyer, MT Vielberg, MW Hackl, J Vomacka, VS Korotkov, ... Angewandte Chemie International Edition 54 (52), 15892-15896, 2015 | 50 | 2015 |
Design and synthesis of tailored human caseinolytic protease P inhibitors TF Gronauer, MM Mandl, M Lakemeyer, MW Hackl, M Meßner, ... Chemical Communications 54 (70), 9833-9836, 2018 | 32 | 2018 |
Quantitative map of β-lactone-induced virulence regulation J Krysiak, M Stahl, J Vomacka, C Fetzer, M Lakemeyer, A Fux, SA Sieber Journal of proteome research 16 (3), 1180-1192, 2017 | 29 | 2017 |
Tailored Peptide Phenyl Esters Block ClpXP Proteolysis by an Unusual Breakdown into a Heptamer–Hexamer Assembly M Lakemeyer, E Bertosin, F Möller, D Balogh, R Strasser, H Dietz, ... Angewandte Chemie International Edition 58 (21), 7127-7132, 2019 | 18 | 2019 |
Über bisherige Denkweisen hinaus–neue Wirkstoffe zur Überwindung der Antibiotika‐Krise M Lakemeyer, W Zhao, FA Mandl, P Hammann, SA Sieber Angewandte Chemie 130 (44), 14642-14682, 2018 | 15 | 2018 |
Reversible Inhibitoren arretieren ClpP in einer definierten Konformation, die durch Bindung von ClpX aufgehoben wird A Pahl, M Lakemeyer, MT Vielberg, MW Hackl, J Vomacka, VS Korotkov, ... Angewandte Chemie 127 (52), 16121-16126, 2015 | 13 | 2015 |
Chemoproteomic identification of a DPP4 homolog in Bacteroides thetaiotaomicron LJ Keller, TH Nguyen, LJ Liu, BM Hurysz, M Lakemeyer, M Guerra, ... Nature Chemical Biology, 1-11, 2023 | 6 | 2023 |
Antibiotic Acyldepsipeptides Stimulate the Streptomyces Clp-ATPase/ClpP Complex for Accelerated Proteolysis L Reinhardt, D Thomy, M Lakemeyer, LM Westermann, J Ortega, ... Mbio 13 (6), e01413-22, 2022 | 5 | 2022 |
Toxoplasma gondii serine hydrolases regulate parasite lipid mobilization during growth and replication within the host O Onguka, BM Babin, M Lakemeyer, IT Foe, N Amara, SM Terrell, ... Cell Chemical Biology 28 (10), 1501-1513. e5, 2021 | 5 | 2021 |
Structure of Staphylococcus aureus ClpP Bound to the Covalent Active Site Inhibitor Cystargolide A A Illigmann, MT Vielberg, M Lakemeyer, F Wolf, T Dema, P Stange, ... Angewandte Chemie (International ed. in English), e202314028, 2023 | 3 | 2023 |
Uncovering an overlooked consequence of phosphorylation: change in cysteine reactivity M Lakemeyer, M Bogyo Nature Methods 19 (3), 281-283, 2022 | 3 | 2022 |
Integration of bioinformatic and chemoproteomic tools for the study of enzyme conservation in closely related bacterial species LJ Keller, M Lakemeyer, M Bogyo Methods in enzymology 664, 1-22, 2022 | 3 | 2022 |
Chemoproteomic identification of a dipeptidyl peptidase 4 (DPP4) homolog in Bacteroides thetaiotaomicron important for envelope integrity and fitness LJ Keller, TH Nguyen, L Liu, M Lakemeyer, DJ Gelsinger, R Chanin, ... bioRxiv, 2022.07. 25.501481, 2022 | 1 | 2022 |
Blockade der ClpXP‐vermittelten Proteolyse mit maßgeschneiderten Peptid‐Phenylestern durch den ungewöhnlichen Zerfall in eine Heptamer‐Hexamer‐Anordnung M Lakemeyer, E Bertosin, F Möller, D Balogh, R Strasser, H Dietz, ... Angewandte Chemie 131 (21), 7201-7206, 2019 | | 2019 |