Human variability in isoform-specific UDP-glucuronosyltransferases: markers of acute and chronic exposure, polymorphisms and uncertainty factors EEJ Kasteel, K Darney, NI Kramer, J Dorne, LS Lautz Archives of toxicology 94, 2637-2661, 2020 | 41 | 2020 |
Human variability in glutathione-S-transferase activities, tissue distribution and major polymorphic variants: Meta-analysis and implication for chemical risk assessment FM Buratti, K Darney, S Vichi, L Turco, E Di Consiglio, LS Lautz, ... Toxicology letters 337, 78-90, 2021 | 31 | 2021 |
Acetylcholinesterase inhibition in electric eel and human donor blood: an in vitro approach to investigate interspecies differences and human variability in toxicodynamics EEJ Kasteel, SM Nijmeijer, K Darney, LS Lautz, JLCM Dorne, NI Kramer, ... Archives of Toxicology 94 (12), 4055-4065, 2020 | 28 | 2020 |
Effect of high-frequency radiations on survival of the honeybee (Apis mellifera L.) K Darney, A Giraudin, R Joseph, P Abadie, P Aupinel, A Decourtye, ... Apidologie 47, 703-710, 2016 | 28 | 2016 |
Bayesian meta-analysis of inter-phenotypic differences in human serum paraoxonase-1 activity for chemical risk assessment K Darney, EEJ Kasteel, FM Buratti, L Turco, S Vichi, C Béchaux, ... Environment international 138, 105609, 2020 | 24 | 2020 |
Human variability in polymorphic CYP2D6 metabolism: Implications for the risk assessment of chemicals in food and emerging designer drugs K Darney, LS Lautz, C Béchaux, W Wiecek, E Testai, B Amzal, J Dorne Environment International 156, 106760, 2021 | 23 | 2021 |
Human variability in influx and efflux transporters in relation to uncertainty factors for chemical risk assessment K Darney, L Turco, FM Buratti, E Di Consiglio, S Vichi, AC Roudot, ... Food and Chemical Toxicology 140, 111305, 2020 | 23 | 2020 |
Risk assessment of chemicals in food and feed: principles, applications and future perspectives L Ingenbleek, LS Lautz, G Dervilly, K Darney, MC Astuto, J Tarazona, ... | 22 | 2020 |
Human variability in carboxylesterases and carboxylesterase-related uncertainty factors for chemical risk assessment E Di Consiglio, K Darney, FM Buratti, L Turco, S Vichi, E Testai, LS Lautz, ... Toxicology Letters 350, 162-170, 2021 | 21 | 2021 |
Modelling human variability in toxicokinetic and toxicodynamic processes using Bayesian meta‐analysis, physiologically‐based modelling and in vitro systems E Testai, C Bechaux, FM Buratti, K Darney, E Di Consiglio, EEJ Kasteel, ... EFSA Supporting Publications 18 (4), 6504E, 2021 | 21 | 2021 |
Aggregate exposure of the adult French population to pyrethroids K Darney, L Bodin, M Bouchard, J Côté, JL Volatier, V Desvignes Toxicology and Applied Pharmacology 351, 21-31, 2018 | 20 | 2018 |
Inter-ethnic differences in CYP3A4 metabolism: a Bayesian meta-analysis for the refinement of uncertainty factors in chemical risk assessment K Darney, E Testai, FM Buratti, E Di Consiglio, EEJ Kasteel, N Kramer, ... Computational Toxicology 12, 100092, 2019 | 17 | 2019 |
OpenCYP: An open source database exploring human variability in activities and frequencies of polymophisms for major cytochrome P-450 isoforms across world populations S Vichi, FM Buratti, E Di Consiglio, L Turco, LS Lautz, K Darney, ... Toxicology Letters 350, 267-282, 2021 | 11 | 2021 |
TKPlate 1.0: An Open‐access platform for Toxicokinetic and Toxicodynamic modelling of chemicals to implement New Approach methodologies in Chemical Risk Assessment JLCM Dorne, J Cortiñas‐Abrahantes, F Spyropoulos, K Darney, L Lautz, ... EFSA Journal 21 (11), e211101, 2023 | 5 | 2023 |
Applications of TKPlate 1.0 for toxicokinetic and toxicodynamic modelling of chemicals: Case Studies European Food Safety Authority (EFSA), H Bossier, F Spyropoulos, ... EFSA Supporting Publications 20 (11), 8440E, 2023 | 4 | 2023 |
Reconnecting exposure, toxicokinetics and toxicity in food safety: OpenFoodTox and TKplate for human health, animal health and ecological risk assessment JL Dorne, B Amzal, N Quignot, W Wiecek, C Bechaux, K Darney, A Grech, ... 54. Congress of the European Societies of Toxicology (EUROTOX 2018) 295 …, 2018 | 4 | 2018 |
User Guide for TKPlate 1.0: An open access platform for implementing new approach methodologies in chemical risk assessment through toxicokinetic and toxicodynamic modelling European Food Safety Authority (EFSA), H Bossier, ... EFSA Supporting Publications 20 (11), 8441E, 2023 | 3 | 2023 |
Towards next generation risk assessment of chemicals: bayesian meta-analysis of human variability in metabolism and transporters and application for the derivation of pathway … K Darney Université de Bretagne occidentale-Brest, 2020 | 1 | 2020 |
Hierarchical Bayesian meta-analysis of human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors for human risk assessment K Darney, E Testai, N Kramer, JLCM Dorne, C Bechaux Toxicology Letters 295, S249, 2018 | 1 | 2018 |
Modeling HepaRG metabolome responses to pyrrolizidine alkaloid exposure for insight into points of departure and modes of action E Dubreil, K Darney, ML Delignette-Muller, A Barranger, S Huet, ... Journal of Hazardous Materials, 134721, 2024 | | 2024 |