Oxidative modifications of glyceraldehyde-3-phosphate dehydrogenase play a key role in its multiple cellular functions NR Hwang, SH Yim, YM Kim, J Jeong, EJ Song, Y Lee, JH Lee, S Choi, ... Biochemical Journal 423 (2), 253-264, 2009 | 194 | 2009 |
In Vivo Albumin Traps Photosensitizer Monomers from Self-Assembled Phthalocyanine Nanovesicles: A Facile and Switchable Theranostic Approach X Li, S Yu, Y Lee, T Guo, N Kwon, D Lee, SC Yeom, Y Cho, G Kim, ... Journal of the American Chemical Society 141 (3), 1366-1372, 2018 | 163 | 2018 |
Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activity BJ Pyun, S Choi, Y Lee, TW Kim, JK Min, Y Kim, BD Kim, JH Kim, TY Kim, ... Cancer research 68 (1), 227-235, 2008 | 106 | 2008 |
Recent advances in structure-based drug design targeting class AG protein-coupled receptors utilizing crystal structures and computational simulations Y Lee, S Basith, S Choi Journal of medicinal chemistry 61 (1), 1-46, 2018 | 99 | 2018 |
Herbal compound farnesiferol C exerts antiangiogenic and antitumor activity and targets multiple aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) signaling cascades JH Lee, S Choi, Y Lee, HJ Lee, KH Kim, KS Ahn, H Bae, HJ Lee, EO Lee, ... Molecular cancer therapeutics 9 (2), 389-399, 2010 | 90 | 2010 |
Transient receptor potential vanilloid type 1 antagonists: a patent review (2011-2014) Y Lee, S Hong, M Cui, PK Sharma, J Lee, S Choi Expert opinion on therapeutic patents 25 (3), 291-318, 2015 | 79 | 2015 |
Structural insights into transient receptor potential vanilloid type 1 (TRPV1) from homology modeling, flexible docking, and mutational studies JH Lee, Y Lee, HC Ryu, DW Kang, J Lee, J Lazar, LV Pearce, ... Journal of computer-aided molecular design 25, 317-327, 2011 | 79 | 2011 |
Mapping the intramolecular signal transduction of G‐protein coupled receptors Y Lee, S Choi, C Hyeon Proteins: Structure, Function, and Bioinformatics 82 (5), 727-743, 2014 | 59 | 2014 |
A novel pyrazole derivative protects from ovariectomy-induced osteoporosis through the inhibition of NADPH oxidase JH Joo, JE Huh, JH Lee, DR Park, Y Lee, SG Lee, S Choi, HJ Lee, ... Scientific reports 6 (1), 22389, 2016 | 55 | 2016 |
X-ray Crystal Structure and Binding Mode Analysis of Human S-Adenosylhomocysteine Hydrolase Complexed with Novel Mechanism-Based Inhibitors, Haloneplanocin A Analogues KM Lee, WJ Choi, Y Lee, HJ Lee, LX Zhao, HW Lee, JG Park, HO Kim, ... Journal of medicinal chemistry 54 (4), 930-938, 2011 | 50 | 2011 |
Structure–Activity Relationships of Truncated C2-or C8-Substituted Adenosine Derivatives as Dual Acting A2A and A3 Adenosine Receptor Ligands X Hou, MS Majik, K Kim, Y Pyee, Y Lee, V Alexander, HJ Chung, HW Lee, ... Journal of medicinal chemistry 55 (1), 342-356, 2011 | 44 | 2011 |
Structure–Activity Relationships of Neplanocin A Analogues as S-Adenosylhomocysteine Hydrolase Inhibitors and Their Antiviral and Antitumor Activities G Chandra, YW Moon, Y Lee, JY Jang, J Song, A Nayak, K Oh, ... Journal of medicinal chemistry 58 (12), 5108-5120, 2015 | 43 | 2015 |
8-hydroxy-2-deoxyguanosine prevents plaque formation and inhibits vascular smooth muscle cell activation through Rac1 inactivation J Young Huh, D Son, Y Lee, J Lee, B Kim, H Myung Lee, H Jo, S Choi, ... Free Radical Biology and Medicine, 2012 | 43 | 2012 |
Importance of protein dynamics in the structure-based drug discovery of class AG protein-coupled receptors (GPCRs) Y Lee, R Lazim, SJY Macalino, S Choi Current opinion in structural biology 55, 147-153, 2019 | 40 | 2019 |
Water-Soluble Phthalocyanines Selectively Bind to Albumin Dimers: A Green Approach Toward Enhancing Tumor-Targeted Photodynamic Therapy X Li, K Jeong, Y Lee, T Guo, D Lee, J Park, N Kwon, JH Na, SK Hong, ... Theranostics 9 (22), 6412-6423, 2019 | 36 | 2019 |
Ultraslow Water-Mediated Transmembrane Interactions Regulate the Activation of A 2A Adenosine Receptor Y Lee, S Kim, S Choi, C Hyeon Biophysical Journal 111 (6), 1180-1191, 2016 | 36 | 2016 |
Communication over the network of binary switches regulates the activation of A2A adenosine receptor Y Lee, S Choi, C Hyeon PLoS computational biology 11 (2), e1004044, 2015 | 35 | 2015 |
Revolutionizing Medicinal Chemistry: The Application of Artificial Intelligence (AI) in Early Drug Discovery R Han, H Yoon, G Kim, H Lee, Y Lee Pharmaceuticals 16 (9), 1259, 2023 | 30 | 2023 |
Synthesis and Anti-Renal Fibrosis Activity of Conformationally Locked Truncated 2-Hexynyl-N 6-Substituted-(N)-Methanocarba-nucleosides as A3 Adenosine Receptor Antagonists and … A Nayak, G Chandra, I Hwang, K Kim, X Hou, HO Kim, PK Sahu, KK Roy, ... Journal of medicinal chemistry 57 (4), 1344-1354, 2014 | 26 | 2014 |
Structural prerequisites for CRM1-dependent nuclear export signaling peptides: accessibility, adapting conformation, and the stability at the binding site Y Lee, J Pei, JM Baumhardt, YM Chook, NV Grishin Scientific reports 9 (1), 6627, 2019 | 25 | 2019 |