| An atomic structure of human γ-secretase X Bai, C Yan, G Yang, P Lu, D Ma, L Sun, R Zhou, SHW Scheres, Y Shi Nature 525 (7568), 212-217, 2015 | 594 | 2015 |
| Three-dimensional structure of human γ-secretase P Lu, X Bai, D Ma, T Xie, C Yan, L Sun, G Yang, Y Zhao, R Zhou, ... Nature 512 (7513), 166-170, 2014 | 411 | 2014 |
| Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase L Sun, R Zhou, G Yang, Y Shi Proceedings of the National Academy of Sciences 114 (4), E476-E485, 2017 | 361 | 2017 |
| Recognition of the amyloid precursor protein by human γ-secretase R Zhou, G Yang, X Guo, Q Zhou, J Lei, Y Shi Science 363 (6428), eaaw0930, 2019 | 300 | 2019 |
| Structural basis of Notch recognition by human γ-secretase G Yang, R Zhou, Q Zhou, X Guo, C Yan, M Ke, J Lei, Y Shi Nature 565 (7738), 192-197, 2019 | 242 | 2019 |
| Structural basis of human γ-secretase assembly L Sun, L Zhao, G Yang, C Yan, R Zhou, X Zhou, T Xie, Y Zhao, S Wu, X Li, ... Proceedings of the National Academy of Sciences 112 (19), 6003-6008, 2015 | 129 | 2015 |
| Structural basis of γ-secretase inhibition and modulation by small molecule drugs G Yang, R Zhou, X Guo, C Yan, J Lei, Y Shi Cell 184 (2), 521-533. e14, 2021 | 118 | 2021 |
| Crystal structure of the γ-secretase component nicastrin T Xie, C Yan, R Zhou, Y Zhao, L Sun, G Yang, P Lu, D Ma, Y Shi Proceedings of the National Academy of Sciences 111 (37), 13349-13354, 2014 | 83 | 2014 |
| Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization R Zhou, G Yang, Y Shi Proceedings of the National Academy of Sciences 114 (48), 12731-12736, 2017 | 64 | 2017 |
| Cryo-EM structures of human γ-secretase G Yang, R Zhou, Y Shi Current Opinion in Structural Biology 46, 55-64, 2017 | 28 | 2017 |
| Macromolecular complex in recognition and proteolysis of amyloid precursor protein in Alzheimer’s disease R Zhou, G Yang, Y Shi Current Opinion in Structural Biology 61, 1-8, 2020 | 19 | 2020 |
| Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560 X Guo, Y Wang, J Zhou, C Jin, J Wang, B Jia, D Jing, C Yan, J Lei, R Zhou, ... Nature Communications 13 (1), 6299, 2022 | 10 | 2022 |
| Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation C Jin, J Wang, Y Wang, B Jia, X Guo, G Yang, P Xu, P Greengard, R Zhou, ... Proceedings of the National Academy of Sciences 119 (12), e2122292119, 2022 | 7 | 2022 |
| Expression, purification, and enzymatic characterization of intramembrane proteases R Zhou, Y Shi, G Yang Methods in Enzymology 584, 127-155, 2017 | 3 | 2017 |
