Reprogramming of protein-targeted small-molecule medicines to RNA by ribonuclease recruitment P Zhang, X Liu, D Abegg, T Tanaka, Y Tong, RI Benhamou, J Baisden, ... Journal of the American Chemical Society 143 (33), 13044-13055, 2021 | 73 | 2021 |
Visualizing a protonated RNA state that modulates microRNA-21 maturation JT Baisden, JA Boyer, B Zhao, SM Hammond, Q Zhang Nature chemical biology 17 (1), 80-88, 2021 | 48 | 2021 |
DNA-encoded library screening to inform design of a ribonuclease targeting chimera (RiboTAC) SM Meyer, T Tanaka, PRA Zanon, JT Baisden, D Abegg, X Yang, ... Journal of the American Chemical Society 144 (46), 21096-21102, 2022 | 42 | 2022 |
Probing excited conformational states of nucleic acids by nitrogen CEST NMR spectroscopy B Zhao, JT Baisden, Q Zhang Journal of Magnetic Resonance 310, 106642, 2020 | 24 | 2020 |
NMR characterization of RNA small molecule interactions RD Thompson, JT Baisden, Q Zhang Methods 167, 66-77, 2019 | 21 | 2019 |
Structural features of small molecules targeting the RNA repeat expansion that causes genetically defined ALS/FTD A Ursu, KW Wang, JA Bush, S Choudhary, JL Chen, JT Baisden, ... ACS chemical biology 15 (12), 3112-3123, 2020 | 15 | 2020 |
A small molecule exploits hidden structural features within the RNA repeat expansion that causes c9ALS/FTD and rescues pathological hallmarks A Ursu, JT Baisden, JA Bush, A Taghavi, S Choudhary, YJ Zhang, ... ACS chemical neuroscience 12 (21), 4076-4089, 2021 | 13 | 2021 |
Transcriptome-Wide Studies of RNA-Targeted Small Molecules Provide a Simple and Selective r(CUG)exp Degrader in Myotonic Dystrophy QMR Gibaut, JA Bush, Y Tong, JT Baisden, A Taghavi, H Olafson, X Yao, ... ACS Central Science 9 (7), 1342-1353, 2023 | 9 | 2023 |
Affecting RNA biology genome-wide by binding small molecules and chemically induced proximity JT Baisden, JL Childs-Disney, LS Ryan, MD Disney Current opinion in chemical biology 62, 119-129, 2021 | 6 | 2021 |
Conformational dynamics of RNA G4C2 and G2C4 repeat expansions causing ALS/FTD using NMR and molecular dynamics studies A Taghavi, JT Baisden, JL Childs-Disney, I Yildirim, MD Disney Nucleic Acids Research 51 (11), 5325-5340, 2023 | 3 | 2023 |
Optimization of a Protein-Targeted Medicine into an RNA-Specific Small Molecule SM Meyer, T Tanaka, A Taghavi, JT Baisden, M Grefe, MD Disney ACS Chemical Biology 18 (11), 2336-2342, 2023 | 1 | 2023 |
Conformational Dynamics of RNA G4C2 and C2G4 Repeat Expansions causing ALS/FTD using NMR and Molecular Dynamics Studies M Disney, A Taghavi, J Baisden, J Childs-Disney, I Yildirim | | 2023 |
Probing Excited Conformational States Involved in microRNA Biogenesis JT Baisden The University of North Carolina at Chapel Hill, 2020 | | 2020 |