Pharmacological properties of furoxans and benzofuroxans: recent developments. H Cerecetto, W Porcal Mini reviews in medicinal chemistry 5 (1), 57-71, 2005 | 195 | 2005 |
Advances in the synthesis and recent therapeutic applications of 1, 2, 4-thiadiazole heterocycles A Castro, T Castaño, A Encinas, W Porcal, C Gil Bioorganic & medicinal chemistry 14 (5), 1644-1652, 2006 | 171 | 2006 |
New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle W Porcal, P Hernández, L Boiani, M Boiani, A Ferreira, A Chidichimo, ... Bioorganic & medicinal chemistry 16 (14), 6995-7004, 2008 | 80 | 2008 |
Benzo [1, 2-c] 1, 2, 5-oxadiazole N-oxide derivatives as potential antitrypanosomal drugs. Part 3: Substituents-clustering methodology in the search for new active compounds G Aguirre, L Boiani, H Cerecetto, R Di Maio, M González, W Porcal, ... Bioorganic & medicinal chemistry 13 (23), 6324-6335, 2005 | 80 | 2005 |
Heteroarylnitrones as drugs for neurodegenerative diseases: synthesis, neuroprotective properties, and free radical scavenger properties W Porcal, P Hernández, M González, A Ferreira, C Olea-Azar, ... Journal of medicinal chemistry 51 (19), 6150-6159, 2008 | 77 | 2008 |
Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity G Álvarez, B Aguirre-López, J Varela, M Cabrera, A Merlino, GV López, ... European journal of medicinal chemistry 45 (12), 5767-5772, 2010 | 71 | 2010 |
Non-ATP competitive glycogen synthase kinase 3β (GSK-3β) inhibitors: study of structural requirements for thiadiazolidinone derivatives A Castro, A Encinas, C Gil, S Bräse, W Porcal, C Pérez, FJ Moreno, ... Bioorganic & medicinal chemistry 16 (1), 495-510, 2008 | 66 | 2008 |
Benzo[1, 2‐c]1, 2, 5‐oxadiazole N‐Oxide Derivatives as Potential Antitrypanosomal Drugs. Structure‐Activity Relationships. Part II G Aguirre, H Cerecetto, R Di Maio, M González, W Porcal, G Seoane, ... Archiv der Pharmazie: An International Journal Pharmaceutical and Medicinal …, 2002 | 58 | 2002 |
Second generation of 5-ethenylbenzofuroxan derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and structure–activity relationships W Porcal, P Hernández, G Aguirre, L Boiani, M Boiani, A Merlino, ... Bioorganic & medicinal chemistry 15 (7), 2768-2781, 2007 | 57 | 2007 |
New potent 5-substituted benzofuroxans as inhibitors of Trypanosoma cruzi growth: Quantitative structure–activity relationship studies G Aguirre, L Boiani, M Boiani, H Cerecetto, R Di Maio, M González, ... Bioorganic & medicinal chemistry 13 (23), 6336-6346, 2005 | 56 | 2005 |
Anti-trypanosomatid benzofuroxans and deoxygenated analogues: Synthesis using polymer-supported triphenylphosphine, biological evaluation and mechanism of action studies D Castro, L Boiani, D Benitez, P Hernandez, A Merlino, C Gil, C Olea-Azar, ... European journal of medicinal chemistry 44 (12), 5055-5065, 2009 | 53 | 2009 |
Novel benzo [1, 2-c] 1, 2, 5-oxadiazole N-oxide derivatives as antichagasic agents: Chemical and biological studies C Olea-Azar, C Rigol, F Mendizábal, H Cerecetto, RD Maio, M González, ... Letters in Drug Design & Discovery 2 (4), 294-301, 2005 | 47 | 2005 |
Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites F Ross, P Hernández, W Porcal, GV López, H Cerecetto, M González, ... PLoS One 7 (4), e35033, 2012 | 46 | 2012 |
Electrochemical and microsomal production of free radicals from 1, 2, 5-oxadiazole N-oxide as potential antiprotozoal drugs C Olea-Azar, C Rigol, F Mendizábal, R Briones, H Cerecetto, R Di Maio, ... Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 59 (1 …, 2003 | 46 | 2003 |
Cytotoxic, mutagenic and genotoxic effects of new anti-T. cruzi 5-phenylethenylbenzofuroxans. Contribution of phase I metabolites on the mutagenicity induction M Cabrera, ML Lavaggi, P Hernández, A Merlino, A Gerpe, W Porcal, ... Toxicology letters 190 (2), 140-149, 2009 | 44 | 2009 |
New heteroaryl nitrones with spin trap properties: Identification of a 4-furoxanyl derivative with excellent properties to be used in biological systems G Barriga, C Olea-Azar, E Norambuena, A Castro, W Porcal, A Gerpe, ... Bioorganic & medicinal chemistry 18 (2), 795-802, 2010 | 42 | 2010 |
In Vivo Anti-Chagas Vinylthio-, Vinylsulfinyl-, and Vinylsulfonylbenzofuroxan Derivatives W Porcal, P Hernández, M Boiani, G Aguirre, L Boiani, A Chidichimo, ... Journal of medicinal chemistry 50 (24), 6004-6015, 2007 | 41 | 2007 |
Preparation of phenazine N5, N10-dioxides: Effects of benzofuroxan substituents in the outcome of their expansion reaction with phenolates H Cerecetto, M González, ML Lavaggi, W Porcal Journal of the Brazilian Chemical Society 16, 1290-1296, 2005 | 33 | 2005 |
In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease L Boiani, C Davies, C Arredondo, W Porcal, A Merlino, A Gerpe, M Boiani, ... European journal of medicinal chemistry 43 (10), 2229-2237, 2008 | 29 | 2008 |
Arylethenylbenzofuroxan derivatives as drugs for Chagas disease: Multigram batch synthesis using a Wittig− Boden process W Porcal, A Merlino, M Boiani, A Gerpe, M González, H Cerecetto Organic Process Research & Development 12 (2), 156-162, 2008 | 27 | 2008 |