CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours H Xu, M Di Antonio, S McKinney, V Mathew, B Ho, NJ O’Neil, ND Santos, ... Nature communications 8 (1), 14432, 2017 | 508 | 2017 |
Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration S Balaban, RF Shearer, LS Lee, M van Geldermalsen, M Schreuder, ... Cancer & metabolism 5, 1-14, 2017 | 358 | 2017 |
TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes T Gudjonsson, M Altmeyer, V Savic, L Toledo, C Dinant, M Grøfte, ... Cell 150 (4), 697-709, 2012 | 358 | 2012 |
Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: Challenges and opportunities L Belfiore, DN Saunders, M Ranson, KJ Thurecht, G Storm, KL Vine Journal of controlled release 277, 1-13, 2018 | 259 | 2018 |
Walking the tightrope: proteostasis and neurodegenerative disease JJ Yerbury, L Ooi, A Dillin, DN Saunders, DM Hatters, PM Beart, ... Journal of neurochemistry 137 (4), 489-505, 2016 | 217 | 2016 |
Revisiting the biological roles of PAI2 (SERPINB2) in cancer DR Croucher, DN Saunders, S Lobov, M Ranson Nature Reviews Cancer 8 (7), 535-545, 2008 | 207 | 2008 |
Systematic approaches to identify E3 ligase substrates M Iconomou, DN Saunders Biochemical Journal 473 (22), 4083-4101, 2016 | 186 | 2016 |
Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions NE Farrawell, IA Lambert-Smith, ST Warraich, IP Blair, DN Saunders, ... Scientific reports 5 (1), 13416, 2015 | 145 | 2015 |
Adipocyte–tumor cell metabolic crosstalk in breast cancer AJ Hoy, S Balaban, DN Saunders Trends in molecular medicine 23 (5), 381-392, 2017 | 144 | 2017 |
Functional roles of the E3 ubiquitin ligase UBR5 in cancer RF Shearer, M Iconomou, CKW Watts, DN Saunders Molecular Cancer Research 13 (12), 1523-1532, 2015 | 135 | 2015 |
Distinct requirement for an intact dimer interface in wild‐type, V600E and kinase‐dead B‐Raf signalling M Röring, R Herr, GJ Fiala, K Heilmann, S Braun, AE Eisenhardt, ... The EMBO journal 31 (11), 2629-2647, 2012 | 135 | 2012 |
Loss of Cited2 affects trophoblast formation and vascularization of the mouse placenta SL Withington, AN Scott, DN Saunders, KL Floro, JI Preis, J Michalicek, ... Developmental biology 294 (1), 67-82, 2006 | 122 | 2006 |
Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS P Ciryam, IA Lambert-Smith, DM Bean, R Freer, F Cid, GG Tartaglia, ... Proceedings of the National Academy of Sciences 114 (20), E3935-E3943, 2017 | 112 | 2017 |
Germline mutations in CDH1 are infrequent in women with early-onset or familial lobular breast cancers KA Schrader, S Masciari, N Boyd, C Salamanca, J Senz, DN Saunders, ... Journal of medical genetics 48 (1), 64-68, 2011 | 111 | 2011 |
Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro LG Horvath, SM Henshall, JG Kench, DN Saunders, CS Lee, D Golovsky, ... Clinical cancer research 10 (2), 615-625, 2004 | 102 | 2004 |
Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway DR Croucher, F Hochgräfe, L Zhang, L Liu, RJ Lyons, D Rickwood, ... Cancer research 73 (6), 1969-1980, 2013 | 101 | 2013 |
Plasminogen binding and activation at the breast cancer cell surface: the integral role of urokinase activity GE Stillfried, DN Saunders, M Ranson Breast Cancer Research 9, 1-11, 2007 | 101 | 2007 |
SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer NLE Harris, C Vennin, JRW Conway, KL Vine, M Pinese, MJ Cowley, ... Oncogene 36 (30), 4288-4298, 2017 | 89 | 2017 |
Experimental design for stable genetic manipulation in mammalian cell lines: lentivirus and alternatives R Shearer, S Darren Genes to Cells, 2014 | 88 | 2014 |
Edd, the Murine Hyperplastic Disc Gene, Is Essential for Yolk Sac Vascularization and Chorioallantoic Fusion DN Saunders, SL Hird, SL Withington, SL Dunwoodie, MJ Henderson, ... Molecular and cellular biology 24 (16), 7225-7234, 2004 | 87 | 2004 |