Structure elucidation of colibactin and its DNA cross-links M Xue, CS Kim, AR Healy, KM Wernke, Z Wang, MC Frischling, EE Shine, ... Science 365 (6457), eaax2685, 2019 | 195 | 2019 |
Structure and bioactivity of colibactin KM Wernke, M Xue, A Tirla, CS Kim, JM Crawford, SB Herzon Bioorganic & medicinal chemistry letters 30 (15), 127280, 2020 | 56 | 2020 |
Synthesis and reactivity of precolibactin 886 AR Healy, KM Wernke, CS Kim, NR Lees, JM Crawford, SB Herzon Nature chemistry 11 (10), 890-898, 2019 | 36 | 2019 |
Depurination of colibactin-derived interstrand cross-links M Xue, KM Wernke, SB Herzon Biochemistry 59 (7), 892-900, 2020 | 29 | 2020 |
Employing chemical synthesis to study the structure and function of colibactin, a “dark matter” metabolite PC Williams, KM Wernke, A Tirla, SB Herzon Natural product reports 37 (11), 1532-1548, 2020 | 12 | 2020 |
Probing microbiome genotoxicity: a stable colibactin provides insight into structure–activity relationships and facilitates mechanism of action studies KM Wernke, A Tirla, M Xue, YV Surovtseva, FS Menges, SB Herzon Journal of the American Chemical Society 143 (38), 15824-15833, 2021 | 11 | 2021 |
Theaflavins from black tea affect growth, development, and motility in Dictyostelium discoideum AN Ilacqua, JA Shettler, KM Wernke, JK Skalla, KJ McQuade Biochemical and biophysical research communications 491 (2), 449-454, 2017 | 10 | 2017 |
Structure elucidation of colibactin and its DNA cross-links. Science 365: eaax2685 M Xue, CS Kim, AR Healy, KM Wernke, Z Wang, MC Frischling, EE Shine, ... | 9 | 2019 |
The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors MW Dougherty, R Valdés-Mas, KM Wernke, RZ Gharaibeh, Y Yang, ... Neoplasia 43, 100918, 2023 | 7 | 2023 |
Structure elucidation of colibactin M Xue, CS Kim, AR Healy, KM Wernke, Z Wang, MC Frischling, EE Shine, ... bioRxiv, 574053, 2019 | 7 | 2019 |
On the stability and spectroscopic properties of 5-hydroxyoxazole-4-carboxylic acid derivatives A Tirla, KM Wernke, SB Herzon Organic letters 23 (14), 5457-5460, 2021 | 3 | 2021 |
Depurination of colibactin-derived interstrand cross-links M Xue, KM Wernke, SB Herzon bioRxiv, 869313, 2019 | 1 | 2019 |
The Fanconi anemia pathway repairs colibactin-induced DNA interstrand cross-links M Altshuller, X He, EJ MacKrell, KM Wernke, JWH Wong, S Sellés-Baiget, ... bioRxiv, 2024 | | 2024 |
Synthetic colibactins reveal the structural and biological mode-of-action of a microbial carcinogen MW Dougherty, R Valdés-Mas, KM Wernke, RZ Gharaibeh, A Riva, ... Cancer Research 83 (7_Supplement), 1215-1215, 2023 | | 2023 |
Chemoproteomic identification and functional characterization of colibactin-modified proteins that drive colorectal cancer progression N Qiu, D Abegg, D Pechalrieu, KM Wernke, SB Herzon, A Adibekian MOLECULAR & CELLULAR PROTEOMICS 21 (8), S52-S52, 2022 | | 2022 |
Synthetic Studies of Colibactin, a Carcinogenic Gut Microbiome Metabolite KM Wernke Yale University, 2022 | | 2022 |
Chemical Microbiology and Synthesis Reveals the Structure of Colibactin and its Mode of Genotoxicity D Trauner, BS Matsuura Synfacts 15 (12), 1439, 2019 | | 2019 |
Addendum: Synthesis and reactivity of precolibactin 886 AR Healy, KM Wernke, CS Kim, NR Lees, JM Crawford, SB Herzon Nature chemistry 11 (12), 1167-1167, 2019 | | 2019 |