| A potent, versatile disulfide-reducing agent from aspartic acid JC Lukesh III, MJ Palte, RT Raines Journal of the American Chemical Society 134 (9), 4057-4059, 2012 | 184 | 2012 |
| Dithioamine reducing agents RT Raines, J Lukesh US Patent 9,090,662, 2015 | 92 | 2015 |
| Sub-picomolar inhibition of HIV-1 protease with a boronic acid IW Windsor, MJ Palte, JC Lukesh III, B Gold, KT Forest, RT Raines Journal of the American Chemical Society 140 (43), 14015-14018, 2018 | 64 | 2018 |
| Thiols and selenols as electron-relay catalysts for disulfide-bond reduction JC Lukesh III, B VanVeller, RT Raines Angewandte Chemie (International ed. in English) 52 (49), 2013 | 42 | 2013 |
| Synthesis of a potent vinblastine: rationally designed added benign complexity O Allemann, M Brutsch, JC Lukesh III, DM Brody, DL Boger Journal of the American Chemical Society 138 (27), 8376-8379, 2016 | 38 | 2016 |
| An innovative hydrogen peroxide‐sensing scaffold and insight towards its potential as an ROS‐activated persulfide donor RA Hankins, SI Suarez, MA Kalk, NM Green, MN Harty, JC Lukesh III Angewandte Chemie International Edition 59 (49), 22238-22245, 2020 | 35 | 2020 |
| Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer–dimer interface DW Carney, JC Lukesh III, DM Brody, MM Brütsch, DL Boger Proceedings of the National Academy of Sciences 113 (35), 9691-9698, 2016 | 30 | 2016 |
| Highly selective staining and quantification of intracellular lipid droplets with a compact push–pull fluorophore based on benzothiadiazole SI Suarez, CC Warner, H Brown-Harding, AM Thooft, B VanVeller, ... Organic & biomolecular chemistry 18 (3), 495-499, 2020 | 23 | 2020 |
| Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity S Yang, K Sankar, CK Skepper, TJ Barker, JC Lukesh III, DM Brody, ... Chemical science 8 (2), 1560-1569, 2017 | 23 | 2017 |
| Vinblastine 20′ amides: synthetic analogues that maintain or improve potency and simultaneously overcome Pgp-derived efflux and resistance JC Lukesh III, DW Carney, H Dong, RM Cross, V Shukla, KK Duncan, ... Journal of medicinal chemistry 60 (17), 7591-7604, 2017 | 20 | 2017 |
| Organocatalysts of oxidative protein folding inspired by protein disulfide isomerase JC Lukesh III, KA Andersen, KK Wallin, RT Raines Organic & biomolecular chemistry 12 (43), 8598-8602, 2014 | 19 | 2014 |
| Illuminating and alleviating cellular oxidative stress with an ROS-activated, H2S-donating theranostic C Zhu, SI Suarez, JC Lukesh III Tetrahedron Letters 69, 152944, 2021 | 15 | 2021 |
| Mitigation of doxorubicin-induced cardiotoxicity with an H2O2-Activated, H2S-Donating hybrid prodrug Q Hu, RD Yammani, H Brown-Harding, DR Soto-Pantoja, LB Poole, ... Redox Biology 53, 102338, 2022 | 14 | 2022 |
| Selenosulfides Tethered to gem‐Dimethyl Esters: A Robust and Highly Versatile Framework for H2S Probe Development SI Suarez, R Ambrose, MA Kalk, JC Lukesh III Chemistry–A European Journal 25 (69), 15736-15740, 2019 | 14 | 2019 |
| H2S Donors with Cytoprotective Effects in Models of MI/R Injury and Chemotherapy-Induced Cardiotoxicity Q Hu, JC Lukesh III Antioxidants 12 (3), 650, 2023 | 11 | 2023 |
| Arylselenyl Radical-Mediated Cyclization of N-(2-Alkynyl)anilines: Access to 3-Selenylquinolines C Zhu, M Nurko, CS Day, JC Lukesh III The Journal of Organic Chemistry 87 (13), 8390-8395, 2022 | 11 | 2022 |
| Pyrazine-derived disulfide-reducing agent for chemical biology JC Lukesh III, KK Wallin, RT Raines Chemical Communications 50 (67), 9591-9594, 2014 | 10 | 2014 |
| Intramolecular Thiol‐and Selenol‐Assisted Delivery of Hydrogen Sulfide Q Hu, SI Suarez, RA Hankins, JC Lukesh III Angewandte Chemie International Edition 61 (45), e202210754, 2022 | 8 | 2022 |
| An ROS-Responsive Donor That Self-Reports Its H2S Delivery by Forming a Benzoxazole-Based Fluorophore Q Hu, C Zhu, RA Hankins, AR Murmello, GS Marrs, JC Lukesh III Journal of the American Chemical Society 145 (46), 25486-25494, 2023 | 4 | 2023 |
| Enol-mediated delivery of H 2 Se from γ-keto selenides: mechanistic insight and evaluation RA Hankins, ME Carter, C Zhu, C Chen, JC Lukesh Chemical Science 13 (44), 13094-13099, 2022 | 4 | 2022 |
Ronald T. RainesFirmenich Professor of Chemistry, Massachusetts Institute of Technology在 mit.edu 的电子邮件经过验证
