Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development X Shen, RE Ellis, K Lee, CY Liu, K Yang, A Solomon, H Yoshida, ... Cell 107 (7), 893-903, 2001 | 827 | 2001 |
Intercellular coupling confers robustness against mutations in the SCN circadian clock network AC Liu, DK Welsh, CH Ko, HG Tran, EE Zhang, AA Priest, ED Buhr, ... Cell 129 (3), 605-616, 2007 | 813 | 2007 |
Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression DK Welsh, SH Yoo, AC Liu, JS Takahashi, SA Kay Current Biology 14 (24), 2289-2295, 2004 | 803 | 2004 |
The unfolded protein response in nutrient sensing and differentiation RJ Kaufman, D Scheuner, M Schröder, X Shen, K Lee, CY Liu, SM Arnold Nature Reviews Molecular Cell Biology 3 (6), 411-421, 2002 | 795 | 2002 |
Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis EE Zhang, Y Liu, R Dentin, PY Pongsawakul, AC Liu, T Hirota, ... Nature medicine 16 (10), 1152-1156, 2010 | 635 | 2010 |
Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum CY Liu, M Schröder, RJ Kaufman Journal of Biological Chemistry 275 (32), 24881-24885, 2000 | 524 | 2000 |
A genome-wide RNAi screen for modifiers of the circadian clock in human cells EE Zhang, AC Liu, T Hirota, LJ Miraglia, G Welch, PY Pongsawakul, X Liu, ... Cell 139 (1), 199-210, 2009 | 493 | 2009 |
Redundant function of REV-ERBα and β and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms AC Liu, HG Tran, EE Zhang, AA Priest, DK Welsh, SA Kay PLoS genetics 4 (2), e1000023, 2008 | 450 | 2008 |
The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response J Zhou, CY Liu, SH Back, RL Clark, D Peisach, Z Xu, RJ Kaufman Proceedings of the national academy of sciences 103 (39), 14343-14348, 2006 | 445 | 2006 |
A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3β T Hirota, WG Lewis, AC Liu, JW Lee, PG Schultz, SA Kay Proceedings of the National Academy of Sciences 105 (52), 20746-20751, 2008 | 318 | 2008 |
Delay in feedback repression by cryptochrome 1 is required for circadian clock function M Ukai-Tadenuma, RG Yamada, H Xu, JA Ripperger, AC Liu, HR Ueda Cell 144 (2), 268-281, 2011 | 301 | 2011 |
The unfolded protein response CY Liu, RJ Kaufman Journal of cell science 116 (10), 1861-1862, 2003 | 297 | 2003 |
Emergence of noise-induced oscillations in the central circadian pacemaker CH Ko, YR Yamada, DK Welsh, ED Buhr, AC Liu, EE Zhang, MR Ralph, ... PLoS biology 8 (10), e1000513, 2010 | 243 | 2010 |
Guidelines for genome-scale analysis of biological rhythms ME Hughes, KC Abruzzi, R Allada, R Anafi, AB Arpat, G Asher, P Baldi, ... Journal of biological rhythms 32 (5), 380-393, 2017 | 235 | 2017 |
A model of the cell-autonomous mammalian circadian clock HP Mirsky, AC Liu, DK Welsh, SA Kay, FJ Doyle III Proceedings of the National Academy of Sciences 106 (27), 11107-11112, 2009 | 229 | 2009 |
Mammalian circadian signaling networks and therapeutic targets AC Liu, WG Lewis, SA Kay Nature chemical biology 3 (10), 630-639, 2007 | 229 | 2007 |
Circadian regulation of ATP release in astrocytes L Marpegan, AE Swanstrom, K Chung, T Simon, PG Haydon, SK Khan, ... Journal of Neuroscience 31 (23), 8342-8350, 2011 | 193 | 2011 |
mTOR signaling regulates central and peripheral circadian clock function C Ramanathan, ND Kathale, D Liu, C Lee, DA Freeman, JB Hogenesch, ... PLoS genetics 14 (5), e1007369, 2018 | 182 | 2018 |
The protein kinase/endoribonuclease IRE1α that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain CY Liu, HN Wong, JA Schauerte, RJ Kaufman Journal of Biological Chemistry 277 (21), 18346-18356, 2002 | 173 | 2002 |
Structure and intermolecular interactions of the luminal dimerization domain of human IRE1α CY Liu, Z Xu, RJ Kaufman Journal of Biological Chemistry 278 (20), 17680-17687, 2003 | 168 | 2003 |