| The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities TR Kiema, RK Harijan, M Strozyk, T Fukao, SEH Alexson, RK Wierenga Acta Crystallographica Section D: Biological Crystallography 70 (12), 3212-3225, 2014 | 43 | 2014 |
| Mutation update on ACAT1 variants associated with mitochondrial acetoacetyl‐CoA thiolase (T2) deficiency E Abdelkreem, RK Harijan, S Yamaguchi, RK Wierenga, T Fukao Human mutation 40 (10), 1641-1663, 2019 | 35 | 2019 |
| AI is a viable alternative to high throughput screening: a 318-target study Scientific reports 14 (1), 7526, 2024 | 34 | 2024 |
| Catalytic-site design for inverse heavy-enzyme isotope effects in human purine nucleoside phosphorylase RK Harijan*, I Zoi*, D Antoniou, SD Schwartz, ... Proceedings of the National Academy of Sciences 114 (25), 6456-6461, 2017 | 32 | 2017 |
| Genetic resistance to purine nucleoside phosphorylase inhibition in Plasmodium falciparum RG Ducati, HA Namanja-Magliano, RK Harijan, JE Fajardo, A Fiser, ... Proceedings of the National Academy of Sciences 115 (9), 2114-2119, 2018 | 30 | 2018 |
| Phylogenetic relationships and classification of thiolases and thiolase-like proteins of Mycobacterium tuberculosis and Mycobacterium smegmatis P Anbazhagan*, RK Harijan*, TR Kiema, N Janardan, MRN Murthy, ... Tuberculosis 94 (4), 405-412, 2014 | 30 | 2014 |
| A binary arginine methylation switch on histone H3 arginine 2 regulates its interaction with WDR5 BM Lorton, RK Harijan, ES Burgos, JB Bonanno, SC Almo, D Shechter Biochemistry 59 (39), 3696-3708, 2020 | 28 | 2020 |
| Inverse enzyme isotope effects in human purine nucleoside phosphorylase with heavy asparagine labels RK Harijan, I Zoi, D Antoniou, SD Schwartz, VL Schramm Proceedings of the National Academy of Sciences 115 (27), E6209-E6216, 2018 | 27 | 2018 |
| Structural and Mutational Studies on Substrate Specificity and Catalysis of Salmonella typhimurium D-Cysteine Desulfhydrase SR Bharath, S Bisht, RK Harijan, HS Savithri, MRN Murthy PLoS One 7 (5), e36267, 2012 | 24 | 2012 |
| Crystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loop RK Harijan, TR Kiema, MP Karjalainen, N Janardan, MRN Murthy, ... Biochemical Journal 455 (1), 119-130, 2013 | 22 | 2013 |
| Transition-State Analogues of Phenylethanolamine N-Methyltransferase N Mahmoodi, RK Harijan, VL Schramm Journal of the American Chemical Society 142 (33), 14222-14233, 2020 | 20 | 2020 |
| Transition-state analogues of Campylobacter jejuni 5'-methylthioadenosine nucleosidase RG Ducati*, RK Harijan*, SA Cameron, PC Tyler, GB Evans, VL Schramm ACS Chemical Biology, 2018 | 19 | 2018 |
| Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues AS Paparella, BL Aboulache, RK Harijan, KS Potts, PC Tyler, ... Nature communications 12 (1), 6285, 2021 | 18 | 2021 |
| Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase RK Harijan, O Hoff, RG Ducati, RS Firestone, BM Hirsch, GB Evans, ... Journal of medicinal chemistry 62 (7), 3286-3296, 2019 | 18 | 2019 |
| Transition state analogue inhibitors of 5'-deoxyadenosine/5'-methylthioadenosine nucleosidase from Mycobacterium tuberculosis HA Namanja-Magliano, GB Evans, RK Harijan, PC Tyler, VL Schramm Biochemistry, 2017 | 17 | 2017 |
| The characterization and evolutionary relationships of a trypanosomal thiolase M Mazet*, RK Harijan*, TR Kiema, AM Haapalainen, P Morand, J Morales, ... International journal for parasitology 41 (12), 1273-1283, 2011 | 17 | 2011 |
| Small molecule inhibitors targeting the interaction of ricin toxin A subunit with ribosomes XP Li, RK Harijan, JN Kahn, VL Schramm, NE Tumer ACS infectious diseases 6 (7), 1894-1905, 2020 | 15 | 2020 |
| Development of MLPA for human ACAT1 gene and identification of a heterozygous Alu-mediated deletion of exons 3 and 4 in a patient with mitochondrial acetoacetyl-CoA thiolase … T Fukao, Y Aoyama, K Murase, T Hori, RK Harijan, RK Wierenga, ... Molecular genetics and metabolism 110 (1-2), 184-187, 2013 | 11 | 2013 |
| Synthesis and structural characterization of ricin inhibitors targeting ribosome binding using fragment-based methods and structure-based design XP Li, RK Harijan, B Cao, JN Kahn, M Pierce, AM Tsymbal, JY Roberge, ... Journal of medicinal chemistry 64 (20), 15334-15348, 2021 | 9 | 2021 |
| Crystallographic substrate binding studies of Leishmania mexicana SCP2-thiolase (type-2): unique features of oxyanion hole-1 RK Harijan, TR Kiema, SM Syed, I Qadir, M Mazet, F Bringaud, ... Protein Engineering, Design and Selection 30 (3), 227-236, 2017 | 8 | 2017 |
