| Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus MJ Sofia, D Bao, W Chang, J Du, D Nagarathnam, S Rachakonda, ... Journal of medicinal chemistry 53 (19), 7202-7218, 2010 | 751 | 2010 |
| Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase MJ Sofia, W Chang, PA Furman, RT Mosley, BS Ross Journal of medicinal chemistry 55 (6), 2481-2531, 2012 | 352 | 2012 |
| Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977 E Murakami, T Tolstykh, H Bao, C Niu, HMM Steuer, D Bao, W Chang, ... Journal of biological chemistry 285 (45), 34337-34347, 2010 | 345 | 2010 |
| Structural basis for RNA replication by the hepatitis C virus polymerase TC Appleby, JK Perry, E Murakami, O Barauskas, J Feng, A Cho, D Fox III, ... Science 347 (6223), 771-775, 2015 | 335 | 2015 |
| Nucleoside phosphoramidate prodrugs MJ Sofia, J Du, P Wang US Patent 7,964,580, 2011 | 231 | 2011 |
| PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus … AM Lam, E Murakami, C Espiritu, HMM Steuer, C Niu, M Keilman, H Bao, ... Antimicrobial agents and chemotherapy 54 (8), 3187-3196, 2010 | 204 | 2010 |
| Nucleoside phosphoramidates B Ross, MJ Sofia, GR Pamulapati, S Rachakonda, HR Zhang, BK Chun, ... US Patent 8,642,756, 2014 | 177 | 2014 |
| Cationic facial amphiphiles: a promising class of transfection agents. S Walker, MJ Sofia, R Kakarla, NA Kogan, L Wierichs, CB Longley, ... Proceedings of the National Academy of Sciences 93 (4), 1585-1590, 1996 | 170 | 1996 |
| Nucleoside phosphoramidate prodrugs MJ Sofia, J Du, P Wang, D Nagarathnam US Patent 8,334,270, 2012 | 164 | 2012 |
| Synthesis of diastereomerically pure nucleotide phosphoramidates BS Ross, P Ganapati Reddy, HR Zhang, S Rachakonda, MJ Sofia The Journal of organic chemistry 76 (20), 8311-8319, 2011 | 160 | 2011 |
| The mechanism of action of β-d-2′-deoxy-2′-fluoro-2′-C-methylcytidine involves a second metabolic pathway leading to β-d-2′-deoxy-2′-fluoro-2′-C-methyluridine 5 … E Murakami, C Niu, H Bao, HM Micolochick Steuer, T Whitaker, ... Antimicrobial agents and chemotherapy 52 (2), 458-464, 2008 | 158 | 2008 |
| Carbohydrate-based small-molecule scaffolds for the construction of universal pharmacophore mapping libraries MJ Sofia, R Hunter, TY Chan, A Vaughan, R Dulina, H Wang, D Gange The Journal of Organic Chemistry 63 (9), 2802-2803, 1998 | 151 | 1998 |
| Haloenol lactones. Potent enzyme-activated irreversible inhibitors for alpha-chymotrypsin. SB Daniels, E Cooney, MJ Sofia, PK Chakravarty, JA Katzenellenbogen Journal of Biological Chemistry 258 (24), 15046-15053, 1983 | 145 | 1983 |
| Structure of hepatitis C virus polymerase in complex with primer-template RNA RT Mosley, TE Edwards, E Murakami, AM Lam, RL Grice, J Du, MJ Sofia, ... Journal of virology 86 (12), 6503-6511, 2012 | 142 | 2012 |
| Stereospecific reductive methylation via a radical cyclization desilylation process G Stork, MJ Sofia Journal of the American Chemical Society 108 (21), 6826-6828, 1986 | 140 | 1986 |
| Nucleoside cyclicphosphates J Du, D Nagarathnam, GR Pamulapati, BS Ross, MJ Sofia US Patent 8,173,621, 2012 | 133 | 2012 |
| Stereospecific Solution-and Solid-Phase Glycosylations. Synthesis of β-Linked Saccharides and Construction of Disaccharide Libraries Using Phenylsulfenyl 2-Deoxy-2 … DJ Silva, H Wang, NM Allanson, RK Jain, MJ Sofia The Journal of Organic Chemistry 64 (16), 5926-5929, 1999 | 131 | 1999 |
| Nucleoside phosphoramidates BS Ross, MJ Sofia, GR Pamulapati, S Rachakonda, HR Zhang, BK Chun, ... US Patent 8,618,076, 2013 | 125 | 2013 |
| Design of compounds that increase the absorption of polar molecules CL Bowe, L Mokhtarzadeh, P Venkatesan, S Babu, HR Axelrod, MJ Sofia, ... Proceedings of the National Academy of Sciences 94 (22), 12218-12223, 1997 | 123 | 1997 |
| Nucleotide prodrugs for HCV therapy MJ Sofia Antiviral Chemistry and Chemotherapy 22 (1), 23-49, 2011 | 116 | 2011 |
