Transcriptional regulation by the numbers: models L Bintu, NE Buchler, HG Garcia, U Gerland, T Hwa, J Kondev, R Phillips Current opinion in genetics & development 15 (2), 116-124, 2005 | 928 | 2005 |
Transcriptional regulation by the numbers: applications L Bintu, NE Buchler, HG Garcia, U Gerland, T Hwa, J Kondev, T Kuhlman, ... Current opinion in genetics & development 15 (2), 125-135, 2005 | 477 | 2005 |
Nucleosomal fluctuations govern the transcription dynamics of RNA polymerase II C Hodges, L Bintu, L Lubkowska, M Kashlev, C Bustamante Science 325 (5940), 626-628, 2009 | 444 | 2009 |
Dynamics of epigenetic regulation at the single-cell level L Bintu Science 351 (6274), 720-724, 2016 | 424 | 2016 |
Nucleosomal elements that control the topography of the barrier to transcription L Bintu, T Ishibashi, M Dangkulwanich, YY Wu, L Lubkowska, M Kashlev, ... Cell 151 (4), 738-749, 2012 | 206 | 2012 |
The elongation rate of RNA polymerase determines the fate of transcribed nucleosomes L Bintu, M Kopaczynska, C Hodges, L Lubkowska, M Kashlev, ... Nature structural & molecular biology 18 (12), 1394-1399, 2011 | 166 | 2011 |
Nascent RNA structure modulates the transcriptional dynamics of RNA polymerases B Zamft, L Bintu, T Ishibashi, C Bustamante Proceedings of the National Academy of Sciences 109 (23), 8948-8953, 2012 | 118 | 2012 |
Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements J Tycko, M Wainberg, GK Marinov, O Ursu, GT Hess, BK Ego, Aradhana, ... Nature communications 10 (1), 4063, 2019 | 111 | 2019 |
Molecular mechanisms of transcription through single-molecule experiments M Dangkulwanich, T Ishibashi, L Bintu, C Bustamante Chemical reviews 114 (6), 3203-3223, 2014 | 102 | 2014 |
Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome MG Durrant, A Fanton, J Tycko, M Hinks, SS Chandrasekaran, NT Perry, ... Nature biotechnology 41 (4), 488-499, 2023 | 88 | 2023 |
High-throughput discovery and characterization of human transcriptional effectors J Tycko, N DelRosso, GT Hess, A Banerjee, A Mukund, MV Van, BK Ego, ... Cell 183 (7), 2020 | 78 | 2020 |
Mapping chromatin modifications at the single cell level CH Ludwig, L Bintu Development 146 (12), dev170217, 2019 | 56 | 2019 |
Large-scale mapping and mutagenesis of human transcriptional effector domains N DelRosso, J Tycko, P Suzuki, C Andrews, Aradhana, A Mukund, ... Nature 616 (7956), 365-372, 2023 | 51* | 2023 |
The sound of silence: Transgene silencing in mammalian cell engineering A Cabrera, HI Edelstein, F Glykofrydis, KS Love, S Palacios, J Tycko, ... Cell Systems 13 (12), 950-973, 2022 | 49 | 2022 |
Nanobody-mediated control of gene expression and epigenetic memory MV Van, T Fujimori, L Bintu Nature Communications 12 (1), 537, 2021 | 27 | 2021 |
Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project J Dekker, F Alber, S Aufmkolk, BJ Beliveau, BG Bruneau, AS Belmont, ... Molecular cell, 2023 | 21 | 2023 |
Dynamic spreading of chromatin-mediated gene silencing and reactivation between neighboring genes in single cells S Lensch, MH Herschl, CH Ludwig, J Sinha, MM Hinks, A Mukund, ... Elife 11, e75115, 2022 | 17 | 2022 |
Large-scale discovery of recombinases for integrating DNA into the human genome MG Durrant, A Fanton, J Tycko, M Hinks, SS Chandrasekaran, NT Perry, ... BioRxiv, 2021.11. 05.467528, 2021 | 13 | 2021 |
Advancing towards a global mammalian gene regulation model through single-cell analysis and synthetic biology J Tycko, MV Van, MB Elowitz, L Bintu Current Opinion in Biomedical Engineering 4, 174-193, 2017 | 13 | 2017 |
High-throughput functional characterization of combinations of transcriptional activators and repressors AX Mukund, J Tycko, SJ Allen, SA Robinson, C Andrews, J Sinha, ... Cell Systems 14 (9), 746-763. e5, 2023 | 12 | 2023 |