| Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA) H Ratni, M Ebeling, J Baird, S Bendels, J Bylund, KS Chen, N Denk, ... Journal of Medicinal Chemistry 61 (15), 6501-6517, 2018 | 514 | 2018 |
| IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure–response relationships and points of departure (PoDs) JT MacGregor, R Frötschl, PA White, KS Crump, DA Eastmond, ... Mutation Research/Genetic Toxicology and Environmental Mutagenesis 783, 55-65, 2015 | 122 | 2015 |
| IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk JT MacGregor, R Frötschl, PA White, KS Crump, DA Eastmond, ... Mutation Research/Genetic Toxicology and Environmental Mutagenesis 783, 66-78, 2015 | 121 | 2015 |
| Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2-and 4-week repeat-dose studies A Rothfuss, M O’Donovan, M De Boeck, D Brault, A Czich, L Custer, ... Mutation Research/Genetic Toxicology and Environmental Mutagenesis 702 (1 …, 2010 | 118 | 2010 |
| Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay SM Bryce, DT Bernacki, JC Bemis, RA Spellman, ME Engel, M Schuler, ... Environmental and Molecular Mutagenesis 58 (3), 146-161, 2017 | 72 | 2017 |
| The photo comet assay—a fast screening assay for the determination of photogenotoxicity in vitro M Struwe, KO Greulich, W Suter, U Plappert-Helbig Mutation Research/Genetic Toxicology and Environmental Mutagenesis 632 (1-2 …, 2007 | 72 | 2007 |
| Assessment of mechanisms driving non-linear dose–response relationships in genotoxicity testing M Guerard, M Baum, A Bitsch, G Eisenbrand, A Elhajouji, B Epe, ... Mutation Research/Reviews in Mutation Research 763, 181-201, 2015 | 68 | 2015 |
| An appraisal of critical effect sizes for the benchmark dose approach to assess dose–response relationships in genetic toxicology A Zeller, G Duran-Pacheco, M Guérard Archives of Toxicology 91, 3799-3807, 2017 | 45 | 2017 |
| A comparison of transgenic rodent mutation and in vivo comet assay responses for 91 chemicals D Kirkland, DD Levy, MJ LeBaron, MJ Aardema, C Beevers, J Bhalli, ... Mutation Research/Genetic Toxicology and Environmental Mutagenesis 839, 21-35, 2019 | 42 | 2019 |
| Detection of photogenotoxicity in skin and eye in rat with the photo comet assay M Struwe, KO Greulich, U Junker, C Jean, D Zimmer, W Sutera, ... Photochemical & Photobiological Sciences 7, 240-249, 2008 | 38 | 2008 |
| Genotoxicity assessment of peptide/protein-related biotherapeutics: points to consider before testing V Thybaud, P Kasper, Z Sobol, A Elhajouji, M Fellows, M Guerard, ... Mutagenesis 31 (4), 375-384, 2016 | 29 | 2016 |
| Influence of experimental conditions on data variability in the liver comet assay M Guérard, C Marchand, U Plappert‐Helbig Environmental and Molecular Mutagenesis 55 (2), 114-121, 2014 | 22 | 2014 |
| Assessment of the Genotoxic Potential of Azidothymidine in the Comet, Micronucleus, and Pig-a Assay M Guérard, J Koenig, M Festag, SD Dertinger, T Singer, G Schmitt, ... toxicological sciences 135 (2), 309-316, 2013 | 19 | 2013 |
| A proposal for a novel rationale for critical effect size in dose–response analysis based on a multi-endpoint in vivo study with methyl methanesulfonate A Zeller, L Tang, SD Dertinger, J Funk, G Duran-Pacheco, M Guérard Mutagenesis 31 (3), 239-253, 2016 | 17 | 2016 |
| Genotoxicity Profile of Azidothymidine In Vitro A Zeller, J Koenig, G Schmitt, T Singer, M Guérard toxicological sciences 135 (2), 317-327, 2013 | 17 | 2013 |
| Repair of sparfloxacin-induced photochemical DNA damage in vivo M Struwe, KO Greulich, E Perentes, HJ Martus, W Suter, ... Journal of investigative dermatology 129 (3), 699-704, 2009 | 16 | 2009 |
| Quantitative assessment of the dose–response of alkylating agents in DNA repair proficient and deficient ames tester strains L Tang, M Guérard, A Zeller Environmental and Molecular Mutagenesis 55 (1), 15-23, 2014 | 15 | 2014 |
| In vitro genotoxicity of neutral red after photo-activation and metabolic activation in the Ames test, the micronucleus test and the comet assay M Guérard, A Zeller, T Singer, E Gocke Mutation Research/Genetic Toxicology and Environmental Mutagenesis 746 (1 …, 2012 | 15 | 2012 |
| Comprehensive assessment of the photomutagenicity, photogenotoxicity and photo (cyto) toxicity of azulene M Struwe, M Csato, T Singer, E Gocke Mutation Research/Genetic Toxicology and Environmental Mutagenesis 723 (2 …, 2011 | 15 | 2011 |
| Possibility of methodical bias in analysis of comet assay studies: Re: DNA damage detected by the alkaline comet assay in the liver of mice after oral administration of … M Struwe, A Zeller, T Singer, E Gocke Mutagenesis 26 (3), 473-474, 2011 | 14 | 2011 |
