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Moreno Wichert
Moreno Wichert
Principal Scientist and Functional Leader DELT platform at Hoffmann-La Roche Ltd, Basel, Switzerland
在 roche.com 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation
M Wichert, N Krall, W Decurtins, RM Franzini, F Pretto, P Schneider, ...
Nature chemistry 7 (3), 241-249, 2015
2132015
20 years of DNA-encoded chemical libraries
L Mannocci, M Leimbacher, M Wichert, J Scheuermann, D Neri
Chemical Communications 47 (48), 12747-12753, 2011
1782011
Automated screening for small organic ligands using DNA-encoded chemical libraries
W Decurtins, M Wichert, RM Franzini, F Buller, MA Stravs, Y Zhang, D Neri, ...
Nature protocols 11 (4), 764-780, 2016
1322016
Identification of Structure–Activity Relationships from Screening a Structurally Compact DNA‐Encoded Chemical Library
RM Franzini, T Ekblad, N Zhong, M Wichert, W Decurtins, A Nauer, ...
Angewandte Chemie 127 (13), 3999-4003, 2015
1062015
Targeting carbonic anhydrase IX with small organic ligands
M Wichert, N Krall
Current opinion in chemical biology 26, 48-54, 2015
372015
A multifaceted hit-finding approach reveals novel LC3 family ligands
M Steffek, E Helgason, N Popovych, L Rougé, JM Bruning, KS Li, ...
Biochemistry 62 (3), 633-644, 2022
142022
Augmenting Chemical Space with DNA-encoded Library Technology and Machine Learning: Medicinal Chemistry and Chemical Biology Highlights
L Guasch, M Reutlinger, D Stoffler, M Wichert
Chimia 75 (1-2), 105-105, 2021
72021
Small molecule drug conjugates
N Krall, W Decurtins, D Neri, J Scheuermann, M Wichert
ES Patent App. 15,702,001 T, 2019
32019
Production of encoded chemical libraries
W Decurtins, R Franzini, D Neri, J Scheuermann, M Wichert
US Patent 10,240,147, 2019
22019
Small molecule drug conjugates
N Krall, W Decurtins, D Neri, J Scheuermann, M Wichert
US Patent 10,016,511, 2018
12018
Challenges and Prospects of DNA-Encoded Library Data Interpretation
M Wichert, L Guasch, RM Franzini
Chemical Reviews 124 (22), 12551-12572, 2024
2024
Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding
J Liang, MJ Lambrecht, TL Arenzana, S Aubert-Nicol, L Bao, F Broccatelli, ...
ACS Medicinal Chemistry Letters, 2024
2024
Small molecule drug conjugates
N Krall, W Decurtins, D Neri, J Scheuermann, M Wichert
US Patent App. 18/170,914, 2023
2023
Small Molecule Drug Conjugates
N Krall, W Decurtins, D Neri, J Scheuermann, M Wichert
US Patent App. 17/209,519, 2021
2021
Production of encoded chemical libraries
W Decurtins, R Franzini, D Neri, J Scheuermann, M Wichert
US Patent App. 16/365,437, 2020
2020
Small Molecule Drug Conjugates
N Krall, W Decurtins, D Neri, J Scheuermann, M Wichert
US Patent App. 16/004,921, 2018
2018
Small molecule drug conjugates
N Krall, W Decurtins, D Neri, J Scheuermann, M Wichert
US Patent 9,884,122, 2018
2018
Bile Acids, Chemical Libraries, Ebola Virus, and Bacterial Uracil
M Wichert
Chemistry & Biology 22, 2015
2015
DNA-encoded self-assembling chemical library technology for de novo ligand discovery and tumor targeting applications
MA Wichert
ETH Zurich, 2015
2015
DNA-encoded chemical libraries: An emerging technology for efficient ligand discovery
M Leimbacher, L Mannocci, M Wichert, J Scheuermann, D Neri
MEDCHEM NEWS 22 (2), 7-14, 2012
2012
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