| Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets M Jiang, J Wang, J Fu, L Du, H Jeong, T West, L Xiang, Q Peng, Z Hou, ... Nature medicine 18 (1), 153-158, 2012 | 376 | 2012 |
| trans-(−)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington disease J Fu, J Jin, RH Cichewicz, SA Hageman, TK Ellis, L Xiang, Q Peng, ... Journal of Biological Chemistry 287 (29), 24460-24472, 2012 | 206 | 2012 |
| The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model Q Peng, N Masuda, M Jiang, Q Li, M Zhao, CA Ross, W Duan Experimental neurology 210 (1), 154-163, 2008 | 198 | 2008 |
| Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease M Jiang, Q Peng, X Liu, J Jin, Z Hou, J Zhang, S Mori, CA Ross, K Ye, ... Human molecular genetics 22 (12), 2462-2470, 2013 | 138 | 2013 |
| Longitudinal characterization of brain atrophy of a Huntington's disease mouse model by automated morphological analyses of magnetic resonance images J Zhang, Q Peng, Q Li, N Jahanshad, Z Hou, M Jiang, N Masuda, ... Neuroimage 49 (3), 2340-2351, 2010 | 111 | 2010 |
| Baicalein reduces E46K α‐synuclein aggregation in vitro and protects cells against E46K α‐synuclein toxicity in cell models of familiar Parkinsonism M Jiang, Y Porat‐Shliom, Z Pei, Y Cheng, L Xiang, K Sommers, Q Li, ... Journal of neurochemistry 114 (2), 419-429, 2010 | 99 | 2010 |
| Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease J Jin, Q Peng, Z Hou, M Jiang, X Wang, AJ Langseth, M Tao, PB Barker, ... Human molecular genetics 24 (9), 2508-2527, 2015 | 91 | 2015 |
| Characterization of behavioral, neuropathological, brain metabolic and key molecular changes in zQ175 knock-in mouse model of Huntington’s disease Q Peng, B Wu, M Jiang, J Jin, Z Hou, J Zheng, J Zhang, W Duan PloS one 11 (2), e0148839, 2016 | 74 | 2016 |
| Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin E Waldron-Roby, T Ratovitski, XF Wang, M Jiang, E Watkin, N Arbez, ... Journal of Neuroscience 32 (1), 183-193, 2012 | 64 | 2012 |
| Sirtuin 1 activator SRT 2104 protects Huntington's disease mice M Jiang, J Zheng, Q Peng, Z Hou, J Zhang, S Mori, JL Ellis, GP Vlasuk, ... Annals of clinical and translational neurology 1 (12), 1047-1052, 2014 | 56 | 2014 |
| Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease N Masuda, Q Peng, Q Li, M Jiang, Y Liang, X Wang, M Zhao, W Wang, ... Neurobiology of disease 30 (3), 293-302, 2008 | 56 | 2008 |
| Post-translational modifications (PTMs), identified on endogenous huntingtin, cluster within proteolytic domains between HEAT repeats T Ratovitski, RN O’Meally, M Jiang, R Chaerkady, E Chighladze, ... Journal of proteome research 16 (8), 2692-2708, 2017 | 55 | 2017 |
| Small molecule modulator of protein disulfide isomerase attenuates mutant huntingtin toxicity and inhibits endoplasmic reticulum stress in a mouse model of Huntington’s disease X Zhou, G Li, A Kaplan, MM Gaschler, X Zhang, Z Hou, M Jiang, R Zott, ... Human molecular genetics 27 (9), 1545-1555, 2018 | 52 | 2018 |
| Metformin protects cells from mutant huntingtin toxicity through activation of AMPK and modulation of mitochondrial dynamics J Jin, H Gu, NM Anders, T Ren, M Jiang, M Tao, Q Peng, MA Rudek, ... Neuromolecular medicine 18, 581-592, 2016 | 52 | 2016 |
| 2, 4 DNP improves motor function, preserves medium spiny neuronal identity, and reduces oxidative stress in a mouse model of Huntington's disease B Wu, M Jiang, Q Peng, G Li, Z Hou, GL Milne, S Mori, R Alonso, ... Experimental Neurology 293, 83-90, 2017 | 50 | 2017 |
| Metabolism in HD: still a relevant mechanism? W Duan, M Jiang, J Jin Movement Disorders 29 (11), 1366-1374, 2014 | 50 | 2014 |
| Long-term potentiation of excitatory synapses on neocortical somatostatin-expressing interneurons HX Chen, M Jiang, D Akakin, SN Roper Journal of neurophysiology 102 (6), 3251-3259, 2009 | 33 | 2009 |
| Gender-and age-specific impairment of rat performance in the Morris water maze following prenatal exposure to an MRI magnetic field ML Jiang, TZ Han, W Pang, L Li Brain research 995 (1), 140-144, 2004 | 27 | 2004 |
| Interaction of huntingtin with PRMTs and its subsequent arginine methylation affects HTT solubility, phase transition behavior and neuronal toxicity T Ratovitski, M Jiang, RN O'meally, P Rauniyar, E Chighladze, A Faragó, ... Human molecular genetics 31 (10), 1651-1672, 2022 | 25 | 2022 |
| Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington’s disease M Jiang, X Zhang, H Liu, J LeBron, A Alexandris, Q Peng, H Gu, F Yang, ... Human molecular genetics 29 (8), 1340-1352, 2020 | 14 | 2020 |
