Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing CA Mitchell, EV Verovskaya, FJ Calero-Nieto, OC Olson, JW Swann, ... Nature cell biology 25 (1), 30-41, 2023 | 96 | 2023 |
A comprehensive transcriptome signature of murine hematopoietic stem cell aging A Flohr Svendsen, D Yang, KM Kim, S Lazare, N Skinder, E Zwart, ... Blood, The Journal of the American Society of Hematology 138 (6), 439-451, 2021 | 89 | 2021 |
Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1 S Renders, AF Svendsen, J Panten, N Rama, M Maryanovich, ... Nature communications 12 (1), 608, 2021 | 67 | 2021 |
Taking One Step Back in Familial Hypercholesterolemia: STAP1 Does Not Alter Plasma LDL (Low-Density Lipoprotein) Cholesterol in Mice and Humans N Loaiza, ML Hartgers, LF Reeskamp, JW Balder, A Rimbert, V Bazioti, ... Arteriosclerosis, thrombosis, and vascular biology 40 (4), 973-985, 2020 | 42 | 2020 |
T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice V Bazioti, AM La Rose, S Maassen, F Bianchi, R de Boer, B Halmos, ... Nature communications 13 (1), 3799, 2022 | 39 | 2022 |
Taz protects hematopoietic stem cells from an aging-dependent decrease in PU. 1 activity KM Kim, A Mura-Meszaros, M Tollot, MS Krishnan, M Gründl, L Neubert, ... Nature communications 13 (1), 5187, 2022 | 26 | 2022 |
CD34+ acute myeloid leukemia cells with low levels of reactive oxygen species show increased expression of stemness genes and can be targeted by the BCL2 inhibitor venetoclax K Mattes, M Gerritsen, H Folkerts, M Geugien, FA van den Heuvel, ... haematologica 105 (8), e399, 2020 | 14 | 2020 |
Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia AM La Rose, V Bazioti, JA Hoogerland, AF Svendsen, AG Groenen, ... Molecular metabolism 53, 101265, 2021 | 9 | 2021 |
Persistent expression of microRNA-125a targets is required to induce murine hematopoietic stem cell repopulating activity DG Luinenburg, AB Dinitzen, AF Svendsen, R Cengiz, A Ausema, ... Experimental hematology 94, 47-59. e5, 2021 | 5 | 2021 |
Inflammatory changes in the bone marrow microenvironment drive both niche and blood system remodeling during aging E Verovskaya, F Calero-Nieto, D Reynaud, SY Zhang, A Herault, ... Experimental Hematology 64, S43-S44, 2018 | 4 | 2018 |
Stromal inflammation is a targetable driver of hematopoietic aging EV Verovskaya, CA Mitchell, FJ Calero-Nieto, A Hérault, PV Dellorusso, ... Biorxiv, 2021.03. 08.434485, 2021 | 3 | 2021 |
Elevated granulocyte-colony stimulating factor and hematopoietic stem cell mobilization in Niemann-Pick type C1 disease AG Groenen, AM La Rose, M Li, V Bazioti, AF Svendsen, NJ Kloosterhuis, ... Journal of Lipid Research 63 (2), 2022 | 2 | 2022 |
Differentiating erythroblasts adapt to turbulent flow by accelerating maturation and activating cholesterol biosynthesis G Iacono, A Abay, JS Gallego Murillo, F Aglialoro, N Yagci, K Fu, ... bioRxiv, 2023.12. 08.570773, 2023 | 1 | 2023 |
Is the philosopher’s stone to rejuvenate blood stem cells an epigenetic regulator? AF Svendsen, G de Haan Nature Aging 2 (11), 980-981, 2022 | 1 | 2022 |
Neogenin-1: Identification of a novel receptor associated with hematopoietic stem cell aging A Svendsen, S Lazare, D Yang, J Jung, B Dethmers, E Weersing, ... Experimental Hematology 64, S106, 2018 | 1 | 2018 |
Differentiating erythroblasts adapt to mechanical stimulation by upregulation of cholesterol biosynthesis via S1P/SREBP-induced HMGCR expression G Iacono, A Abay, JSG Murillo, F Aglialoro, N Yagci, E Varga, T Bijlsma, ... Scientific Reports 14 (1), 1-15, 2024 | | 2024 |
Lu/BCAM Expression Defines Functionally Distinct Red Blood Cells NO Chahdi, S Neri, TTRL Klei, S Philipsen, S Tol, J Geissler, BM Beuger, ... Blood 144, 2454, 2024 | | 2024 |
3168–HEMATOPOIETIC ORGANOIDS FROM HUMAN INDUCED PLURIPOTENT STEM CELLS: MIMICKING HEMATOPOIETIC DEVELOPMENT IN VITRO AF Svendsen, L Dijkhuis, E Solabarrieta, E Varga, E van den Akker, ... Experimental Hematology 137, 104488, 2024 | | 2024 |
LSD1/KDM1A and GFI1B repress endothelial fate and induce hematopoietic fate in induced pluripotent stem cell-derived hemogenic endothelium H Zhang, M Hansen, F Di Summa, M Von Lindern, N Gillemans, ... Haematologica 109 (12), 3975, 2024 | | 2024 |
PB0387 Characterising the Molecular Pathways Controlled by ETV6 during Megakaryopoiesis H Zhang, E Huisman, M Hansen, A Svendsen, A Hoogendijk, ... Research and Practice in Thrombosis and Haemostasis 7, 2023 | | 2023 |