| Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors ME Flanagan, JA Abramite, DP Anderson, A Aulabaugh, UP Dahal, ... Journal of medicinal chemistry 57 (23), 10072-10079, 2014 | 304 | 2014 |
| Small molecule quantification by liquid chromatography-mass spectrometry for metabolites of drugs and drug candidates UP Dahal, JP Jones, JA Davis, DA Rock Drug metabolism and disposition 39 (12), 2355-2360, 2011 | 69 | 2011 |
| Intrinsic reactivity profile of electrophilic moieties to guide covalent drug design: N-α-acetyl-l-lysine as an amine nucleophile UP Dahal, AM Gilbert, RS Obach, ME Flanagan, JM Chen, ... MedChemComm 7 (5), 864-872, 2016 | 66 | 2016 |
| Benchmarking in Vitro Covalent Binding Burden As a Tool To Assess Potential Toxicity Caused by Nonspecific Covalent Binding of Covalent Drugs UP Dahal, RS Obach, AM Gilbert Chemical Research in Toxicology 26 (11), 1739-1745, 2013 | 66 | 2013 |
| The role of protein-protein and protein-membrane interactions on P450 function EE Scott, CR Wolf, M Otyepka, SC Humphreys, JR Reed, CJ Henderson, ... Drug Metabolism and Disposition 44 (4), 576-590, 2016 | 53 | 2016 |
| Comparative study of the affinity and metabolism of type I and type II binding quinoline carboxamide analogues by cytochrome P450 3A4 UP Dahal, C Joswig-Jones, JP Jones Journal of medicinal chemistry 55 (1), 280-290, 2012 | 38 | 2012 |
| The kinetic mechanism for cytochrome P450 metabolism of type II binding compounds: evidence supporting direct reduction J Pearson, UP Dahal, D Rock, CC Peng, JO Schenk, C Joswig-Jones, ... Archives of biochemistry and biophysics 511 (1-2), 69-79, 2011 | 31 | 2011 |
| Strain-dependent variability of early discovery small molecule pharmacokinetics in mice: does strain matter? JT Barr, TB Tran, BM Rock, JL Wahlstrom, UP Dahal Drug Metabolism and Disposition 48 (8), 613-621, 2020 | 17 | 2020 |
| Targeting the mitotic kinesin KIF18A in chromosomally unstable cancers: hit optimization toward an in vivo chemical probe NA Tamayo, MP Bourbeau, JR Allen, KS Ashton, JJ Chen, MR Kaller, ... Journal of Medicinal Chemistry 65 (6), 4972-4990, 2022 | 16 | 2022 |
| Fraction unbound for liver microsome and hepatocyte incubations for all major species can be approximated using a single-species surrogate JT Barr, JM Lade, TB Tran, UP Dahal Drug Metabolism and Disposition 47 (4), 419-423, 2019 | 15 | 2019 |
| Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers M Payton, B Belmontes, K Hanestad, J Moriguchi, K Chen, JD McCarter, ... Nature Cancer 5 (1), 66-84, 2024 | 12 | 2024 |
| Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRASG12C, are associated with renal toxicity in the Sprague Dawley rat JA Werner, R Davies, J Wahlstrom, UP Dahal, M Jiang, J Stauber, ... Toxicology and Applied Pharmacology 423, 115578, 2021 | 12 | 2021 |
| A tag‐free collisionally induced fragmentation approach to detect drug‐adducted proteins by mass spectrometry TE Ballard, UP Dahal, AJ Bessire, RP Schneider, KF Geoghegan, ... Rapid Communications in Mass Spectrometry 29 (22), 2175-2183, 2015 | 12 | 2015 |
| Therapeutic protein drug interactions: a white paper from the international consortium for innovation and quality in pharmaceutical development DE Coutant, DW Boulton, UP Dahal, A Deslandes, C Grimaldi, ... Clinical Pharmacology & Therapeutics 113 (6), 1185-1198, 2023 | 11 | 2023 |
| Absorption, metabolism and excretion of [14C]-sotorasib in healthy male subjects: characterization of metabolites and a minor albumin-sotorasib conjugate I Vuu, UP Dahal, Z Wang, X Shen, J Rodgers, J Wahlstrom, B Houk Cancer Chemotherapy and Pharmacology 90 (4), 357-367, 2022 | 10 | 2022 |
| Acid-catalyzed conjugate additions to 3-fluorobutenone TB Patrick, UP Dahal Journal of Fluorine Chemistry 130 (5), 470-473, 2009 | 8 | 2009 |
| Absorption, distribution, metabolism, and excretion of [14C]-sotorasib in rats and dogs: interspecies differences in absorption, protein conjugation and metabolism UP Dahal, BM Rock, J Rodgers, X Shen, Z Wang, JL Wahlstrom Drug Metabolism and Disposition 50 (5), 600-612, 2022 | 6 | 2022 |
| discovery and preclinical characterization of AMG 650, a first-in-class inhibitor of kinesin KIF18A motor protein with potent activity against chromosomally unstable cancers B Belmontes, J Moriguchi, G Chung, J Sun, MSS Ninniri, K Hanestad, ... Cancer Research 83 (7_Supplement), 516-516, 2023 | 5 | 2023 |
| Development and Evaluation of Ontogeny Functions of the Major UDP‐Glucuronosyltransferase Enzymes to Underwrite Physiologically Based Pharmacokinetic Modeling in Pediatric … N Farhan, UP Dahal, J Wahlstrom The Journal of Clinical Pharmacology 64 (10), 1222-1235, 2024 | | 2024 |
| Xenografted Tumors Share Comparable Fraction Unbound and Can Be Surrogated by Mouse Lung Tissue M Wang, S Kuldharan, A Shenoy, S Reddy, K Rex, T Osgood, ... Drug Metabolism and Disposition 52 (7), 644-653, 2024 | | 2024 |
