Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses Y Kim, S Lovell, KC Tiew, SR Mandadapu, KR Alliston, KP Battaile, ... Journal of virology 86 (21), 11754-11762, 2012 | 368 | 2012 |
Reversal of the progression of fatal coronavirus infection in cats by a broad-spectrum coronavirus protease inhibitor Y Kim, H Liu, AC Galasiti Kankanamalage, S Weerasekara, DH Hua, ... PLoS pathogens 12 (3), e1005531, 2016 | 279 | 2016 |
Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis NC Pedersen, Y Kim, H Liu, AC Galasiti Kankanamalage, C Eckstrand, ... Journal of feline medicine and surgery 20 (4), 378-392, 2018 | 251 | 2018 |
Inhibition of influenza virus replication by plant-derived isoquercetin Y Kim, S Narayanan, KO Chang Antiviral research 88 (2), 227-235, 2010 | 241 | 2010 |
3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice AD Rathnayake, J Zheng, Y Kim, KD Perera, S Mackin, DK Meyerholz, ... Science translational medicine 12 (557), eabc5332, 2020 | 228 | 2020 |
Bile acids are essential for porcine enteric calicivirus replication in association with down-regulation of signal transducer and activator of transcription 1 KO Chang, SV Sosnovtsev, G Belliot, Y Kim, LJ Saif, KY Green Proceedings of the National Academy of Sciences 101 (23), 8733-8738, 2004 | 178 | 2004 |
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element ACG Kankanamalage, Y Kim, VC Damalanka, AD Rathnayake, AR Fehr, ... European journal of medicinal chemistry 150, 334-346, 2018 | 114 | 2018 |
Synthesis and antiviral activity of substituted quercetins M Thapa, Y Kim, J Desper, KO Chang, DH Hua Bioorganic & medicinal chemistry letters 22 (1), 353-356, 2012 | 100 | 2012 |
Global survey of the frequency of atrial fibrillation–associated stroke: Embolic Stroke of Undetermined Source Global Registry KS Perera, T Vanassche, J Bosch, B Swaminathan, H Mundl, ... Stroke 47 (9), 2197-2202, 2016 | 97 | 2016 |
Broad-spectrum inhibitors against 3C-like proteases of feline coronaviruses and feline caliciviruses Y Kim, V Shivanna, S Narayanan, AM Prior, S Weerasekara, DH Hua, ... Journal of virology 89 (9), 4942-4950, 2015 | 96 | 2015 |
Potent inhibition of feline coronaviruses with peptidyl compounds targeting coronavirus 3C-like protease Y Kim, SR Mandadapu, WC Groutas, KO Chang Antiviral research 97 (2), 161-168, 2013 | 88 | 2013 |
Antiviral drug discovery: norovirus proteases and development of inhibitors KO Chang, Y Kim, S Lovell, AD Rathnayake, WC Groutas Viruses 11 (2), 197, 2019 | 84 | 2019 |
The effects of simvastatin or interferon-α on infectivity of human norovirus using a gnotobiotic pig model for the study of antivirals K Jung, Q Wang, Y Kim, K Scheuer, Z Zhang, Q Shen, KO Chang, LJ Saif PloS one 7 (7), e41619, 2012 | 84 | 2012 |
Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors AM Prior, Y Kim, S Weerasekara, M Moroze, KR Alliston, RAZ Uy, ... Bioorganic & medicinal chemistry letters 23 (23), 6317-6320, 2013 | 80 | 2013 |
Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles SR Mandadapu, PM Weerawarna, MR Gunnam, KR Alliston, ... Bioorganic & medicinal chemistry letters 22 (14), 4820-4826, 2012 | 77 | 2012 |
Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection CS Dampalla, J Zheng, KD Perera, LYR Wong, DK Meyerholz, ... Proceedings of the National Academy of Sciences 118 (29), e2101555118, 2021 | 75 | 2021 |
Protective immunity and antibody-secreting cell responses elicited by combined oral attenuated Wa human rotavirus and intranasal Wa 2/6-VLPs with mutant Escherichia coli heat … L Yuan, C Iosef, MSP Azevedo, Y Kim, Y Qian, A Geyer, TV Nguyen, ... Journal of virology 75 (19), 9229-9238, 2001 | 75 | 2001 |
Characterization of group C rotaviruses associated with diarrhea outbreaks in feeder pigs Y Kim, KO Chang, B Straw, LJ Saif Journal of clinical microbiology 37 (5), 1484-1488, 1999 | 70 | 1999 |
Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease KC Tiew, G He, S Aravapalli, SR Mandadapu, MR Gunnam, KR Alliston, ... Bioorganic & medicinal chemistry letters 21 (18), 5315-5319, 2011 | 67 | 2011 |
Structure-guided design and optimization of dipeptidyl inhibitors of norovirus 3CL protease. Structure–activity relationships and biochemical, X-ray crystallographic, cell … AC Galasiti Kankanamalage, Y Kim, PM Weerawarna, RAZ Uy, ... Journal of medicinal chemistry 58 (7), 3144-3155, 2015 | 66 | 2015 |