| Characterization of a mouse model of obesity-related fibrotic cardiomyopathy that recapitulates features of human heart failure with preserved ejection fraction L Alex, I Russo, V Holoborodko, NG Frangogiannis American Journal of Physiology-Heart and Circulatory Physiology 315 (4 …, 2018 | 138 | 2018 |
| Distinct roles of myofibroblast-specific Smad2 and Smad3 signaling in repair and remodeling of the infarcted heart S Huang, B Chen, Y Su, L Alex, C Humeres, AV Shinde, SJ Conway, ... Journal of molecular and cellular cardiology 132, 84-97, 2019 | 72 | 2019 |
| Western diet-fed, aortic-banded Ossabaw swine: a preclinical model of cardio-metabolic heart failure TD Olver, JC Edwards, TJ Jurrissen, AB Veteto, JL Jones, C Gao, C Rau, ... JACC: Basic to Translational Science 4 (3), 404-421, 2019 | 67 | 2019 |
| Left atrial remodeling, hypertrophy, and fibrosis in mouse models of heart failure W Hanif, L Alex, YA Su, AV Shinde, I Russo, N Li, NG Frangogiannis Cardiovascular Pathology 30, 27-37, 2017 | 66 | 2017 |
| Smad7 effects on TGF-β and ErbB2 restrain myofibroblast activation and protect from postinfarction heart failure C Humeres, AV Shinde, A Hanna, L Alex, SC Hernández, R Li, B Chen, ... The Journal of clinical investigation 132 (3), 2022 | 59 | 2022 |
| The role of Smad2 and Smad3 in regulating homeostatic functions of fibroblasts in vitro and in adult mice S Huang, B Chen, C Humeres, L Alex, A Hanna, NG Frangogiannis Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1867 (7), 118703, 2020 | 42 | 2020 |
| Pericytes in the infarcted heart L Alex, NG Frangogiannis Vascular Biology 1 (1), H23-H31, 2019 | 34 | 2019 |
| The cellular origin of activated fibroblasts in the infarcted and remodeling myocardium L Alex, NG Frangogiannis Circulation research 122 (4), 540-542, 2018 | 26 | 2018 |
| Validation of specific and reliable genetic tools to identify, label, and target cardiac pericytes in mice L Alex, I Tuleta, V Harikrishnan, NG Frangogiannis Journal of the American Heart Association 11 (1), e023171, 2022 | 25 | 2022 |
| Collagen denaturation in the infarcted myocardium involves temporally distinct effects of MT1-MMP-dependent proteolysis and mechanical tension A Hanna, AV Shinde, R Li, L Alex, C Humeres, P Balasubramanian, ... Matrix Biology 99, 18-42, 2021 | 22 | 2021 |
| cIAP-2 protects cardiac fibroblasts from oxidative damage: an obligate regulatory role for ERK1/2 MAPK and NF-κB L Philip, K Shivakumar Journal of molecular and cellular cardiology 62, 217-226, 2013 | 22 | 2013 |
| Identification of macrophages in normal and injured mouse tissues using reporter lines and antibodies B Chen, R Li, A Kubota, L Alex, NG Frangogiannis Scientific reports 12 (1), 4542, 2022 | 20 | 2022 |
| Cardiac pericytes acquire a fibrogenic phenotype and contribute to vascular maturation after myocardial infarction L Alex, I Tuleta, SC Hernandez, A Hanna, H Venugopal, M Astorkia, ... Circulation 148 (11), 882-898, 2023 | 19 | 2023 |
| NF-κB inhibition compromises cardiac fibroblast viability under hypoxia M Sangeetha, MS Pillai, L Philip, EG Lakatta, K Shivakumar Experimental cell research 317 (7), 899-909, 2011 | 18 | 2011 |
| Diabetes induces cardiac fibroblast activation, promoting a matrix‐preserving nonmyofibroblast phenotype, without stimulating pericyte to fibroblast conversion L Alex, I Tuleta, A Hanna, NG Frangogiannis Journal of the American Heart Association 12 (6), e027463, 2023 | 5 | 2023 |
| Pericytes in the infarcted heart. Vasc Biol. 2019; 1: H23–H31. doi: 10.1530 L Alex, NG Frangogiannis VB-19-0007 Crossref Medline, 0 | 5 | |
| Abstract MP262: Endogenous Smad7 restrains myofibroblast activation and protects from post-infarction heart failure by suppressing tgf-beta signaling and by directly inhibiting … C Humeres, AV Shinde, A Hanna, L Alex, S Conway, NG Frangogiannis Circulation Research 129 (Suppl_1), AMP262-AMP262, 2021 | 1 | 2021 |
| Endothelial cell sphingosine 1-phosphate receptor 1 restrains VE-cadherin cleavage and attenuates experimental inflammatory arthritis N Burg, R Malpass, L Alex, M Tran, E Englebrecht, A Kuo, T Pannelini, ... JCI insight 9 (11), 2024 | | 2024 |
| Fibroblast-specific TGF-b Signaling Promotes Interstitial Fibrosis, Cardiomyocyte Hypertrophy And Cardiac Dysfunction In The Diabetic Heart Through Smad3 Activation I Tuleta, L Alex, H Venugopal, C Humeres, SC Hernandez, A Kubota, ... CIRCULATION RESEARCH 133, 2023 | | 2023 |
| Abstract P2051: Fibroblast-specific TGF-b Signaling Promotes Interstitial Fibrosis, Cardiomyocyte Hypertrophy And Cardiac Dysfunction In The Diabetic Heart Through Smad3 Activation I Tuleta, L Alex, H Venugopal, C Humeres, SC Hernandez, A Kubota, ... Circulation Research 133 (Suppl_1), AP2051-AP2051, 2023 | | 2023 |
