SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway H Xu, IA Akinyemi, SA Chitre, JC Loeb, JA Lednicky, MT McIntosh, ... Virology 568, 13-22, 2022 | 106 | 2022 |
SARS-CoV-2 viroporin triggers the NLRP3 inflammatory pathway H Xu, SA Chitre, IA Akinyemi, JC Loeb, JA Lednicky, MT McIntosh, ... BioRxiv, 2020.10. 27.357731, 2020 | 36 | 2020 |
HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules M Stevens, S Abdeen, N Salim, AM Ray, A Washburn, S Chitre, J Sivinski, ... Bioorganic & medicinal chemistry letters 29 (9), 1106-1112, 2019 | 35 | 2019 |
Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections A Washburn, S Abdeen, Y Ovechkina, AM Ray, M Stevens, S Chitre, ... Bioorganic & medicinal chemistry letters 29 (13), 1665-1672, 2019 | 19 | 2019 |
Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs M Stevens, C Howe, AM Ray, A Washburn, S Chitre, J Sivinski, Y Park, ... Bioorganic & medicinal chemistry 28 (22), 115710, 2020 | 14 | 2020 |
Exploiting the HSP60/10 chaperonin system as a chemotherapeutic target for colorectal cancer AM Ray, N Salim, M Stevens, S Chitre, S Abdeen, A Washburn, J Sivinski, ... Bioorganic & medicinal chemistry 40, 116129, 2021 | 12 | 2021 |
Bis-aryl-α, β-unsaturated ketone (ABK) chaperonin inhibitors exhibit selective cytotoxicity to colorectal cancer cells that correlates with levels of aberrant HSP60 in the cytosol S Chitre, AM Ray, M Stevens, EH Doud, H Liechty, A Washburn, K Tepper, ... Bioorganic & Medicinal Chemistry 75, 117072, 2022 | 4 | 2022 |
SMALL MOLECULE MODULATION OF HSP60/10 CHAPERONIN SYSTEMS: MORE COMMON THAN PREVIOUSLY THOUGHT? M Stevens, S Abdeen, N Salim, AM Ray, A Washburn, S Chitre, J Sivinski, ... PROTEIN SCIENCE 28, 112-113, 2019 | | 2019 |
Small-molecule modulation of HSP60/10 chaperonin systems: A therapeutic strategy over 100 years in the making? M Stevens, S Abdeen, AM Ray, A Washburn, S Chitre, J Sivinski, Y Park, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 257, 2019 | | 2019 |
Investigating Chalcones and their Ability to Inhibit the Human HSP60/10 Chaperonin System and Colorectal Cancer Cells SA Chitre | | 2019 |