CAR T cell immunotherapy for human cancer CH June, RS O’Connor, OU Kawalekar, S Ghassemi, MC Milone Science 359 (6382), 1361-1365, 2018 | 2574 | 2018 |
Cells test substrate rigidity by local contractions on submicrometer pillars S Ghassemi, G Meacci, S Liu, AA Gondarenko, A Mathur, ... Proceedings of the National Academy of Sciences 109 (14), 5328-5333, 2012 | 314 | 2012 |
Reducing Ex Vivo Culture Improves the Antileukemic Activity of Chimeric Antigen Receptor (CAR) T Cells S Ghassemi, S Nunez-Cruz, RS O'Connor, JA Fraietta, PR Patel, ... Cancer immunology research 6 (9), 1100-1109, 2018 | 245 | 2018 |
ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion A Chronopoulos, B Robinson, M Sarper, E Cortes, V Auernheimer, ... Nature communications 7 (1), 12630, 2016 | 238 | 2016 |
Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices H Wolfenson, G Meacci, S Liu, MR Stachowiak, T Iskratsch, S Ghassemi, ... Nature cell biology 18 (1), 33-42, 2016 | 206 | 2016 |
Decoding information in cell shape P Rangamani, A Lipshtat, EU Azeloglu, RC Calizo, M Hu, S Ghassemi, ... Cell 154 (6), 1356-1369, 2013 | 190 | 2013 |
The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations RS O’Connor, L Guo, S Ghassemi, NW Snyder, AJ Worth, L Weng, Y Kam, ... Scientific reports 8 (1), 6289, 2018 | 158 | 2018 |
Rapid manufacturing of non-activated potent CAR T cells S Ghassemi, JS Durgin, S Nunez-Cruz, J Patel, J Leferovich, M Pinzone, ... Nature biomedical engineering 6 (2), 118-128, 2022 | 152 | 2022 |
Force generated by actomyosin contraction builds bridges between adhesive contacts OM Rossier, N Gauthier, N Biais, W Vonnegut, MA Fardin, P Avigan, ... The EMBO journal 29 (6), 1055-1068, 2010 | 137 | 2010 |
Methods of making chimeric antigen receptor-expressing cells F Bedoya, S Ghassemi, CH June, BL Levine, JJ Melenhorst, MC Milone, ... US Patent 10,273,300, 2019 | 96 | 2019 |
α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions G Meacci, H Wolfenson, S Liu, MR Stachowiak, T Iskratsch, A Mathur, ... Molecular biology of the cell 27 (22), 3471-3479, 2016 | 86 | 2016 |
Enhancing chimeric antigen receptor T cell anti-tumor function through advanced media design S Ghassemi, FJ Martinez-Becerra, AM Master, SA Richman, D Heo, ... Molecular Therapy Methods & Clinical Development 18, 595-606, 2020 | 60 | 2020 |
Methods for improving the efficacy and expansion of immune cells F Bedoya, S Ghassemi, CH June, OU Kawalekar, BL Levine, ... US Patent 10,829,735, 2020 | 58 | 2020 |
High-throughput mechanobiology screening platform using micro-and nanotopography J Hu, AA Gondarenko, AP Dang, KT Bashour, RS O’Connor, S Lee, ... Nano letters 16 (4), 2198-2204, 2016 | 54 | 2016 |
Fabrication of elastomer pillar arrays with modulated stiffness for cellular force measurements S Ghassemi, N Biais, K Maniura, SJ Wind, MP Sheetz, J Hone Journal of Vacuum Science & Technology B: Microelectronics and Nanometer …, 2008 | 51 | 2008 |
Methods of making chimeric antigen receptor-expressing cells F Bedoya, S Ghassemi, CH June, BL Levine, JJ Melenhorst, MC Milone, ... US Patent App. 16/291,651, 2019 | 31 | 2019 |
Epigenetic strategies to boost CAR T cell therapy B Akbari, N Ghahri-Saremi, T Soltantoyeh, J Hadjati, S Ghassemi, ... Molecular therapy 29 (9), 2640-2659, 2021 | 28 | 2021 |
203. Shortened T cell culture with IL-7 and IL-15 provides the most potent chimeric antigen receptor (CAR)-modified T cells for adoptive immunotherapy S Ghassemi, F Bedoya, S Nunez-Cruz, C June, J Melenhorst, M Milone Molecular Therapy 24, S79, 2016 | 26 | 2016 |
Dynamic force generation by neural stem cells P Shi, K Shen, S Ghassemi, J Hone, LC Kam Cellular and molecular bioengineering 2, 464-474, 2009 | 26 | 2009 |
Methods of making chimeric antigen receptor-expressing cells S Ghassemi, MC Milone, R O'connor US Patent App. 17/602,730, 2022 | 16 | 2022 |