Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events S Uchida, K Hara, A Kobayashi, K Otsuki, H Yamagata, T Hobara, ... Neuron 69 (2), 359-372, 2011 | 451 | 2011 |
New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation A Kimata, H Nakagawa, R Ohyama, T Fukuuchi, S Ohta, T Suzuki, ... Journal of medicinal chemistry 50 (21), 5053-5056, 2007 | 234 | 2007 |
Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure− activity relationship studies and … S Hirashima, T Suzuki, T Ishida, S Noji, S Yata, I Ando, M Komatsu, ... Journal of medicinal chemistry 49 (15), 4721-4736, 2006 | 224 | 2006 |
Identification of cell-active lysine specific demethylase 1-selective inhibitors R Ueda, T Suzuki, K Mino, H Tsumoto, H Nakagawa, M Hasegawa, ... Journal of the American Chemical Society 131 (48), 17536-17537, 2009 | 222 | 2009 |
Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors S Hamada, T Suzuki, K Mino, K Koseki, F Oehme, I Flamme, H Ozasa, ... Journal of medicinal chemistry 53 (15), 5629-5638, 2010 | 188 | 2010 |
Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries T Suzuki, Y Ota, M Ri, M Bando, A Gotoh, Y Itoh, H Tsumoto, PR Tatum, ... Journal of medicinal chemistry 55 (22), 9562-9575, 2012 | 186 | 2012 |
Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: identification of 2-[(4-diarylmethoxy) phenyl]-benzimidazole T Ishida, T Suzuki, S Hirashima, K Mizutani, A Yoshida, I Ando, S Ikeda, ... Bioorganic & medicinal chemistry letters 16 (7), 1859-1863, 2006 | 183 | 2006 |
Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate T Suzuki, A Kouketsu, Y Itoh, S Hisakawa, S Maeda, M Yoshida, ... Journal of medicinal chemistry 49 (16), 4809-4812, 2006 | 167 | 2006 |
Lysine demethylases inhibitors T Suzuki, N Miyata Journal of medicinal chemistry 54 (24), 8236-8250, 2011 | 165 | 2011 |
Hippocampal microRNA-124 enhances chronic stress resilience in mice F Higuchi, S Uchida, H Yamagata, N Abe-Higuchi, T Hobara, K Hara, ... Journal of Neuroscience 36 (27), 7253-7267, 2016 | 160 | 2016 |
Design, synthesis, structure− selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors Y Itoh, T Suzuki, A Kouketsu, N Suzuki, S Maeda, M Yoshida, ... Journal of medicinal chemistry 50 (22), 5425-5438, 2007 | 159 | 2007 |
Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates T Suzuki, Y Nagano, A Kouketsu, A Matsuura, S Maruyama, M Kurotaki, ... Journal of medicinal chemistry 48 (4), 1019-1032, 2005 | 156 | 2005 |
Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors T Suzuki, MNA Khan, H Sawada, E Imai, Y Itoh, K Yamatsuta, N Tokuda, ... Journal of Medicinal Chemistry 55 (12), 5760-5773, 2012 | 141 | 2012 |
Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors S Hamada, TD Kim, T Suzuki, Y Itoh, H Tsumoto, H Nakagawa, ... Bioorganic & medicinal chemistry letters 19 (10), 2852-2855, 2009 | 140 | 2009 |
Non-hydroxamate histone deacetylase inhibitors T Suzuki, N Miyata Current medicinal chemistry 12 (24), 2867-2880, 2005 | 140 | 2005 |
Isoform-selective histone deacetylase inhibitors T Suzuki, Y Itoh, N Miyata Current pharmaceutical design 14 (6), 529-544, 2008 | 138 | 2008 |
Loss of deacetylation activity of Hdac6 affects emotional behavior in mice M Fukada, A Hanai, A Nakayama, T Suzuki, N Miyata, RM Rodriguiz, ... PloS one 7 (2), e30924, 2012 | 132 | 2012 |
Identification of G protein-coupled receptor 120-selective agonists derived from PPARγ agonists T Suzuki, S Igari, A Hirasawa, M Hata, M Ishiguro, H Fujieda, Y Itoh, ... Journal of medicinal chemistry 51 (23), 7640-7644, 2008 | 126 | 2008 |
Thiol-based SAHA analogues as potent histone deacetylase inhibitors T Suzuki, A Kouketsu, A Matsuura, A Kohara, S Ninomiya, K Kohda, ... Bioorganic & medicinal chemistry letters 14 (12), 3313-3317, 2004 | 126 | 2004 |
The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1 AE Tee, D Ling, C Nelson, B Atmadibrata, ME Dinger, N Xu, T Mizukami, ... Oncotarget 5 (7), 1793, 2014 | 125 | 2014 |