The chemistry and pharmacology of citrus limonoids R Gualdani, MM Cavalluzzi, G Lentini, S Habtemariam Molecules 21 (11), 1530, 2016 | 165 | 2016 |
Plant-derived anticancer agents: Lessons from the pharmacology of geniposide and its aglycone, genipin S Habtemariam, G Lentini Biomedicines 6 (2), 39, 2018 | 94 | 2018 |
Ligand efficiency metrics in drug discovery: The pros and cons from a practical perspective MM Cavalluzzi, GF Mangiatordi, O Nicolotti, G Lentini Expert opinion on drug discovery 12 (11), 1087-1104, 2017 | 82 | 2017 |
A mini-review on thalidomide: chemistry, mechanisms of action, therapeutic potential and anti-angiogenic properties in multiple myeloma A Mercurio, G Adriani, A Catalano, A Carocci, L Rao, G Lentini, ... Current medicinal chemistry 24 (25), 2736-2744, 2017 | 81 | 2017 |
The therapeutic potential of rutin for diabetes: an update S Habtemariam, G Lentini Mini Reviews in Medicinal Chemistry 15 (7), 524-528, 2015 | 67 | 2015 |
Molecular determinants of mexiletine structure for potent and use-dependent block of skeletal muscle sodium channels A De Luca, F Natuzzi, JF Desaphy, G Loni, G Lentini, C Franchini, ... Molecular Pharmacology 57 (2), 268-277, 2000 | 67 | 2000 |
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels C Franchini, A Carocci, A Catalano, MM Cavalluzzi, F Corbo, G Lentini, ... Journal of medicinal chemistry 46 (24), 5238-5248, 2003 | 66 | 2003 |
Phytochemical, Antioxidant and Anti‐α‐glucosidase Activity Evaluations of Bergenia cordifolia M Roselli, G Lentini, S Habtemariam Phytotherapy Research 26 (6), 908-914, 2012 | 64 | 2012 |
New N-(phenoxydecyl) phthalimide derivatives displaying potent inhibition activity towards α-glucosidase R Pascale, A Carocci, A Catalano, G Lentini, A Spagnoletta, ... Bioorganic & medicinal chemistry 18 (16), 5903-5914, 2010 | 60 | 2010 |
Stereospecific synthesis of mexiletine and related compounds: Mitsunobu versus Williamson reaction A Carocci, A Catalano, F Corbo, A Duranti, R Amoroso, C Franchini, ... Tetrahedron: Asymmetry 11 (17), 3619-3634, 2000 | 59 | 2000 |
Targeting the pregnane X receptor using microbial metabolite mimicry Z Dvořák, F Kopp, CM Costello, JS Kemp, H Li, A Vrzalová, M Štěpánková, ... EMBO molecular medicine 12 (4), e11621, 2020 | 57 | 2020 |
Old drug scaffold, new activity: thalidomide‐correlated compounds exert different effects on breast cancer cell growth and progression D Iacopetta, A Carocci, MS Sinicropi, A Catalano, G Lentini, J Ceramella, ... ChemMedChem 12 (5), 381-389, 2017 | 55 | 2017 |
Stereoselective effects of mexiletine enantiomers on sodium currents and excitability characteristics of adult skeletal muscle fibers A De Luca, F Natuzzi, G Lentini, C Franchini, V Tortorella, ... Naunyn-Schmiedeberg's archives of pharmacology 352, 653-661, 1995 | 53 | 1995 |
COVID-19, chloroquine repurposing, and cardiac safety concern: chirality might help G Lentini, MM Cavalluzzi, S Habtemariam Molecules 25 (8), 1834, 2020 | 48 | 2020 |
Evaluation of the antimyotonic activity of mexiletine and some new analogs on sodium currents of single muscle fibers and on the abnormal excitability of the myotonic ADR mouse A De Luca, S Pierno, F Natuzzi, C Franchini, A Duranti, G Lentini, ... Journal of Pharmacology and Experimental Therapeutics 282 (1), 93-100, 1997 | 48 | 1997 |
Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide A De Luca, F Natuzzi, G Falcone, A Duranti, G Lentini, C Franchini, ... Naunyn-Schmiedeberg's archives of pharmacology 356, 777-787, 1997 | 45 | 1997 |
Human ether-à-go-go-related potassium channel: Exploring SAR to improve drug design MM Cavalluzzi, P Imbrici, R Gualdani, A Stefanachi, GF Mangiatordi, ... Drug Discovery Today 25 (2), 344-366, 2020 | 44 | 2020 |
Structure-based prediction of hERG-related cardiotoxicity: A benchmark study TM Creanza, P Delre, N Ancona, G Lentini, M Saviano, GF Mangiatordi Journal of Chemical Information and Modeling 61 (9), 4758-4770, 2021 | 42 | 2021 |
Ultrasound and deep eutectic solvents: An efficient combination to tune the mechanism of steviol glycosides extraction G Milani, M Vian, MM Cavalluzzi, C Franchini, F Corbo, G Lentini, ... Ultrasonics Sonochemistry 69, 105255, 2020 | 42 | 2020 |
Design, synthesis, and pharmacological effects of structurally simple ligands for MT1 and MT2 melatonin receptors A Carocci, A Catalano, A Lovece, G Lentini, A Duranti, V Lucini, ... Bioorganic & medicinal chemistry 18 (17), 6496-6511, 2010 | 42 | 2010 |