Bile acids signal via TGR5 to activate intestinal stem cells and epithelial regeneration G Sorrentino, A Perino, E Yildiz, G El Alam, M Bou Sleiman, A Gioiello, ... Gastroenterology 159 (3), 956-968. e8, 2020 | 247 | 2020 |
Transforming growth factor β/activin signaling functions as a sugar-sensing feedback loop to regulate digestive enzyme expression A Chng Wen-Bin, M Bou Sleiman, F Schüpfer, B Lemaitre Cell reports 9 (1), 336-348, 2014 | 105 | 2014 |
Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome E Porcu, MC Sadler, K Lepik, C Auwerx, AR Wood, A Weihs, ... Nature communications 12 (1), 5647, 2021 | 92 | 2021 |
Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence M Bou Sleiman, D Osman, A Massouras, AA Hoffmann, B Lemaitre, ... Nature communications 6 (1), 7829, 2015 | 69 | 2015 |
Systems analyses reveal physiological roles and genetic regulators of liver lipid species P Jha, MT McDevitt, R Gupta, PM Quiros, EG Williams, K Gariani, ... Cell Systems 6 (6), 722-733. e6, 2018 | 63 | 2018 |
The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress TY Li, M Bou Sleiman, H Li, AW Gao, A Mottis, AM Bachmann, GE Alam, ... Nature aging 1 (2), 165-178, 2021 | 62 | 2021 |
An integrated systems genetics and omics toolkit to probe gene function H Li, X Wang, D Rukina, Q Huang, T Lin, V Sorrentino, H Zhang, ... Cell systems 6 (1), 90-102. e4, 2018 | 58 | 2018 |
Genetic regulation of plasma lipid species and their association with metabolic phenotypes P Jha, MT McDevitt, E Halilbasic, EG Williams, PM Quiros, K Gariani, ... Cell systems 6 (6), 709-721. e6, 2018 | 56 | 2018 |
Identifying gene function and module connections by the integration of multispecies expression compendia H Li, D Rukina, FPA David, TY Li, CM Oh, AW Gao, E Katsyuba, ... Genome Research 29 (12), 2034-2045, 2019 | 42 | 2019 |
Gene-by-environment modulation of lifespan and weight gain in the murine BXD family S Roy, M Bou Sleiman, P Jha, JF Ingels, CJ Chapman, MS McCarty, ... Nature metabolism 3 (9), 1217-1227, 2021 | 41* | 2021 |
Sex-and age-dependent genetics of longevity in a heterogeneous mouse population M Bou Sleiman, S Roy, AW Gao, MC Sadler, GVG von Alvensleben, H Li, ... Science 377 (6614), eabo3191, 2022 | 40 | 2022 |
The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress O Matilainen, M Bou Sleiman, PM Quiros, SMDA Garcia, J Auwerx Nature communications 8 (1), 1818, 2017 | 40 | 2017 |
The gene-regulatory footprint of aging highlights conserved central regulators M Bou Sleiman, P Jha, R Houtkooper, RW Williams, X Wang, J Auwerx Cell reports 32 (13), 2020 | 34 | 2020 |
Genetic cartography of longevity in humans and mice: current landscape and horizons M Hook, S Roy, EG Williams, M Bou Sleiman, K Mozhui, JF Nelson, L Lu, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1864 (9 …, 2018 | 32 | 2018 |
Microfluidics-enabled phenotyping of a whole population of C. elegans worms over their embryonic and post-embryonic development at single-organism resolution MC Letizia, M Cornaglia, R Trouillon, V Sorrentino, L Mouchiroud, ... Microsystems & nanoengineering 4 (1), 6, 2018 | 32 | 2018 |
The Black cells phenotype is caused by a point mutation in the Drosophila pro-phenoloxidase 1 gene that triggers melanization and hematopoietic defects C Neyen, O Binggeli, P Roversi, L Bertin, M Bou Sleiman, B Lemaitre Developmental & Comparative Immunology 50 (2), 166-174, 2015 | 27 | 2015 |
The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression G Benegiamo, GVG von Alvensleben, S Rodríguez-López, LJE Goeminne, ... Journal of Experimental Medicine 220 (4), e20221738, 2023 | 23 | 2023 |
Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia PP Laurila, M Wohlwend, T Imamura de Lima, P Luan, S Herzig, N Zanou, ... Nature Aging 2 (12), 1159-1175, 2022 | 23 | 2022 |
COX7A2L genetic variants determine cardiorespiratory fitness in mice and human G Benegiamo, M Bou Sleiman, M Wohlwend, S Rodríguez-López, ... Nature metabolism 4 (10), 1336-1351, 2022 | 19 | 2022 |
Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis H Li, A Perino, Q Huang, GVG Von Alvensleben, A Banaei-Esfahani, ... Cell Metabolism 34 (10), 1594-1610. e4, 2022 | 17 | 2022 |